Abstract: The present disclosure relates to a Camptothecin compound having anti-tumor activity, a preparation method therefor, and an application thereof. Specifically, the present disclosure relates to a compound as shown below or a pharmaceutically acceptable form thereof, a pharmaceutical composition thereof, a preparation method therefor, and a use thereof.

Abstract: Systems and methods described herein relate to the prediction of effects of data purging on data sources that are related through hierarchical data relationships. A purge request comprises a set of purge parameters that identify a data source and define one or more purge criteria for purging of data items of the data source. A plurality of impacted data sources is identified based on one or more hierarchical data relationships held by the data items of the data source. The impacted data sources include the data source and one or more additional data sources. The purge parameters are provided to a machine learning model to obtain output indicative of a predicted effect of execution of the purge request on the impacted data sources. The predicted effect is caused to be presented at the user device prior to the execution of the purge request.

Abstract: The present disclosure relates to a Camptothecin compound having anti-tumor activity, a preparation method therefor, and an application thereof. Specifically, the present disclosure relates to a compound as shown below or a pharmaceutically acceptable form thereof, a pharmaceutical composition thereof, a preparation method therefor, and a use thereof.

Abstract: Provided are an anti-Nectin-4 antibody or antigen-binding fragment thereof, an antibody conjugate comprising the same, and use thereof in the manufacture of a medicament, particularly in the manufacture of a medicament for treating and/or preventing cancer.

Abstract: Systems and methods described herein relate to the real-time verification of data purges. A first subprocess of a data purging process is executed to purge a plurality of data items. A system accesses purge result data providing an indication of a result of the first subprocess. The system determines, based on the purge result data, that the first subprocess was not executed in accordance with a purge policy associated with the data purging process. In response to determining that the first subprocess was not executed in accordance with the purge policy, the system adjusts a state of the data purging process. A second subprocess of the data purging process is then executed according to the adjusted state.

Abstract: Systems and methods described herein relate to the prediction of effects of data purging on data sources that are related through hierarchical data relationships. A purge request comprises a set of purge parameters that identify a data source and define one or more purge criteria for purging of data items of the data source. A plurality of impacted data sources is identified based on one or more hierarchical data relationships held by the data items of the data source. The impacted data sources include the data source and one or more additional data sources. The purge parameters are provided to a machine learning model to obtain output indicative of a predicted effect of execution of the purge request on the impacted data sources. The predicted effect is caused to be presented at the user device prior to the execution of the purge request.

Abstract: Systems and methods described herein relate to the real-time verification of data purges. A first subprocess of a data purging process is executed to purge a plurality of data items. A system accesses purge result data providing an indication of a result of the first subprocess. The system determines, based on the purge result data, that the first subprocess was not executed in accordance with a purge policy associated with the data purging process. In response to determining that the first subprocess was not executed in accordance with the purge policy, the system adjusts a state of the data purging process. A second subprocess of the data purging process is then executed according to the adjusted state.

Abstract: Systems and methods described herein relate to the efficient handling of data purge requests in the context of a distributed storage system. A plurality of data purge requests is stored in a first data structure. The data purge requests may be grouped into batches that are processed at least partially in parallel. A first data purge request from the plurality of data purge requests is successfully processed, and is moved from the first data structure to a second data structure. Processing of a second data purge request from the plurality of data purge requests is unsuccessful. The second data purge request is retained in the first data structure. Purge status data is generated based on the first data purge request being in the second data structure and the second data purge request being in the first data structure. The purge status data may be presented at a user device.

Abstract: Systems and methods described herein relate to the efficient handling of data purge requests in the context of a distributed storage system. A plurality of data purge requests is stored in a first data structure. The data purge requests may be grouped into batches that are processed at least partially in parallel. A first data purge request from the plurality of data purge requests is successfully processed, and is moved from the first data structure to a second data structure. Processing of a second data purge request from the plurality of data purge requests is unsuccessful. The second data purge request is retained in the first data structure. Purge status data is generated based on the first data purge request being in the second data structure and the second data purge request being in the first data structure. The purge status data may be presented at a user device.

Abstract: Provided are an anti-Nectin-4 antibody or antigen-binding fragment thereof, an antibody conjugate comprising the same, and use thereof in the manufacture of a medicament, particularly in the manufacture of a medicament for treating and/or preventing cancer.

Abstract: Provided in the present application are an antibody-drug conjugate, and a preparation method therefor and the use thereof. The antibody drug conjugate has a structure as represented by the formula Ab-[M-L-E-D]x, and the drug is selected from an anti-tubulin agent, a DNA intercalator, a DNA topoisomerase inhibitor and a RNA polymerase inhibitor. The prepared antibody-drug conjugate has a better drug-to-antibody ratio, and has a good targeted killing effect on colon cancer and non-small cell lung cancer (for example, lung adenocarcinoma).

Abstract: Provided are an anti-Nectin-4 antibody or antigen-binding fragment thereof, an antibody conjugate comprising the same, and use thereof in the manufacture of a medicament, particularly in the manufacture of a medicament for treating and/or preventing cancer.

Abstract: The present invention relates to a Camptothecin compound having anti-tumor activity, a preparation method therefor, and an application thereof. Specifically, the present invention relates to a compound as shown below or a pharmaceutically acceptable form thereof, a pharmaceutical composition thereof, a preparation method therefor, and a use thereof.

Abstract: A digital photo frame (DPF) includes a power source, a display panel, a light detector, a motion detector, a processing unit, and a power management unit. The light detector is configured to detect the ambient brightness. The motion detection unit is configured to detect whether anyone is around. The processing unit is connected to the light detector and the motion detector. If the motion detector detects someone is around the DPF and the light detector detects the ambient brightness is below a predetermined value, the processing unit controls the power management unit to provide power to the display panel.

Abstract: A digital photo frame (DPF) capable of indicating battery is provided. The DPF includes a light-emitting diode (LED) unit, a battery, a battery detection unit, a processing unit, and a display control unit. The battery detection unit is connected to the battery and is configured to detect the charge of the battery and output a low battery alarm signal when the charge of the battery is below a predetermined value. The processing unit is connected to the battery detection unit, and is configured to producing a control signal when receiving the low battery alarm signal. The display control unit is connected to the processing unit and the LED unit, and is configured to control the LED unit to change its display state when receiving the control signal.

Abstract: A digital photo frame (DPF) capable of automatically changing display mode is provided. The DPF includes a display unit, a motion detector, a processing unit, and a storage unit. The motion detector is configured to detect whether there is someone around the DPF, and produce a display switching signal if someone is around the DPF. The processing unit detects current display mode when it receives the display switching signal and change the display mode of the DPF to a slide show mode if current display mode is a still mode. The motion detector also produce a stop signal when it detects nobody around the DPF, the processing unit controls the display unit to display the pictures in the still mode when it receives the stop signal and detects current display mode is the slide show mode.

Abstract: A digital photo frame (DPF) capable of attracting attention is provided. The DPF includes a light-emitting diode (LED) unit, a display control unit, a motion detector, and a processing unit. The processing unit is connected to the motion detector and the display control unit, and the display control unit is connected to the LED unit. If the motion detector detects there is someone around the DPF, the processing unit transmits a control signal to the display control unit, and the display control unit control the LED unit to flash in response to the control signal.

Abstract: A digital photo frame (DPF) includes a power source, a display panel, a light detector, a motion detector, a processing unit, and a power management unit. The light detector is configured to detect the ambient brightness. The motion detection unit is configured to detect whether anyone is around. The processing unit is connected to the light detector and the motion detector. If the motion detector detects someone is around the DPF and the light detector detects the ambient brightness is below a predetermined value, the processing unit controls the power management unit to provide power to the display panel.