Abstract: The present application provides a model training method and apparatus, and a molecular property information prediction method and apparatus. The method include: obtaining data of a designated proteolysis targeting chimera molecule; according to the data, constructing three-dimensional molecular graph data of the designated proteolysis targeting chimera molecule; inputting the three-dimensional molecular graph data of the designated proteolysis targeting chimera molecule into a prediction model to be trained, so that the prediction model predicts molecular property information of the designated proteolysis targeting chimera molecule; and according to a deviation between predicted molecular property information and actual molecular property information of the designated proteolysis targeting chimera molecule, training the prediction model.