Abstract: Aggregated log index-based log record identification is provided by maintaining log files of a database system on a plurality log storage devices, the log files including log records of changes to database objects, indexing the log files to obtain a collection of log indexes, where the indexing includes, for each log storage device, indexing log records stored on the log storage device to obtain a respective log index, then based on a request, identifying log storage devices that store log records for servicing the request, the log storage devices storing log indexes, of the collection of log indexes, that index an aggregate set of log records on the log storage devices, obtaining the log indexes from the log storage devices, and aggregating the log indexes to provide an aggregated log index that provides an index of the aggregate set of log records on the log storage devices.

Abstract: The disclosure relates to a switched capacitor converter (SCC) with gate driving circuits for limiting currents provided by switching field effect transistors. Embodiments disclosed include an SCC with gate driver curcuits providing gate voltage signals to power FETs, each gate driver circuit comprising first and second gate driver modules and configured to operate in: a first mode in which the first gate driver module provides a gate voltage signal to a power FET that switches between first and second voltage rails by operation of first and second switches connected between the pair of voltage rails; and a second mode in which, in reponse to enabling of a current limit switching signal, the first gate driver module disables switching of one of the first and second switches and the second gate driver module operates to limit a current provided to the power FET.

Abstract: A MIS capacitor and a method of making the same. The capacitor includes a semiconductor substrate having a first part having a first conductivity type and contact regions for coupling the first part to an output node. The substrate has dielectric on a surface of the first part and electrodes on the dielectric. The substrate has a second part having a second conductivity type and a third part having the first conductivity type. The third part is coupleable to a supply voltage. The second part is located between the first part and the third part. The first part and the second part form a first p-n junction and the second part and the third part form a second p-n junction. A reference contact is provided for coupling the second part to a reference voltage. A further contact region is provided for coupling the second part to the output node.

Abstract: The present invention relates to antibodies and antigen-binding fragments thereof to human BMP6 and compositions and methods of use thereof.

Abstract: The disclosure relates to a switched capacitor converter with gate driving circuits for limiting currents provided by switching field effect transistors.

Abstract: An integrated circuit includes two N wells from two different devices in close proximity to each other with each N well biased by two different terminals. The N wells are at least partially surrounded by P type regions that are biased by a terminal. The integrated circuit includes conductivity reduction features that increase the resistivity of current paths to a P type regions of one device on a side closest the other device. The integrated circuit includes two conductive tie biasing structures each located directly over an N type region of the substrate and directly over a P type region of the substrate. The two conductive tie biasing structures are not electrically connected to each other and are not electrically coupled to each other by a conductive biasing structure.

Abstract: The present invention relates methods of treatment using BMP6 antagonists.

Abstract: A synchronous rectifier converts an AC input into a DC output. The synchronous rectifier has four switches controlled by four switch control modules. Each switch is connected between a different AC component and either the DC output or ground. Each switch control module has digitally assisted “switch on” circuitry that detects “on” bounces in the corresponding AC component to control when to turn on the corresponding switch and digitally assisted “switch off” circuitry that detects “off” bounces in the AC component to control when to turn off the corresponding switch. The “switch on” circuitry has a digitally assisted comparator to detect threshold crossings in the AC component, and the “switch off” circuitry has a digitally assisted programmable delay cell to turn off the switch for a predetermined duration following each detected threshold crossing.

Abstract: Gate-protection circuitry protects a transistor, such as a MOSFET, from large gate-to-source voltage differentials that can permanently damage the transistor's gate-oxide layer. A source-voltage detector selectively enables the gate-protection circuitry based on a source voltage of the transistor. The gate-protection circuit is implemented without any Zener diodes. The transistor may be a load switch that is selectively controlled to apply a supply voltage to a load.

Abstract: The present invention relates methods of treatment using BMP6 antagonists.

Abstract: The present invention relates to antibodies and antigen-binding fragments thereof to human BMP6 and compositions and methods of use thereof.

Abstract: The present invention relates to antibodies targeting LRP6 and compositions and methods of use thereof.

Abstract: A synchronous rectifier converts an AC input into a DC output. The synchronous rectifier has four switches controlled by four switch control modules. Each switch is connected between a different AC component and either the DC output or ground. Each switch control module has digitally assisted “switch on” circuitry that detects “on” bounces in the corresponding AC component to control when to turn on the corresponding switch and digitally assisted “switch off” circuitry that detects “off” bounces in the AC component to control when to turn off the corresponding switch. The “switch on” circuitry has a digitally assisted comparator to detect threshold crossings in the AC component, and the “switch off” circuitry has a digitally assisted programmable delay cell to turn off the switch for a predetermined duration following each detected threshold crossing.

Abstract: The present invention relates to antibodies and antigen-binding fragments thereof to human BMP6 and compositions and methods of use thereof.

Abstract: Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors.

Abstract: Gate-protection circuitry protects a transistor, such as a MOSFET, from large gate-to-source voltage differentials that can permanently damage the transistor's gate-oxide layer. A source-voltage detector selectively enables the gate-protection circuitry based on a source voltage of the transistor. The gate-protection circuit is implemented without any Zener diodes. The transistor may be a load switch that is selectively controlled to apply a supply voltage to a load.

Abstract: The present invention relates to antibodies and antigen-binding fragments thereof to human BMP6 and compositions and methods of use thereof.

Abstract: The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 are negative regulators of ?-catenin and the Wnt signaling pathway in eukaryotic cells. The activity of ZNRF3 can be modulated by antibody binding to its extracellular domain, thus causing an increase in Wnt signaling. The ZNRF3 antagonizing antibodies can be used to treat diseases with low Wnt signaling, such as short bowel syndrome, osteoporosis, diabetes, neurodegenerative diseases, and mucositis. In addition, the antagonizing antibodies of the invention can be used to enhance Wnt signaling for tissue repair and wound healing.

Abstract: The present invention relates to antibodies and antigen-binding fragments thereof to human BMP6 and compositions and methods of use thereof.

Abstract: The present invention relates to antibodies targeting LRP6 and compositions and methods of use thereof.