Abstract: In general, embodiments of the present disclosure relate to pigment containing contact lenses, such as colored contact lenses. In particular, embodiments of the present disclosure relate to a silicon hydrogel (SiHy) contact lens having a layered configuration that completely encapsulates a layer of pigment. In at least some embodiments, a method for forming a contact lens is provided. The method includes applying a clear ink to at least an iris portion of a mold and curing the clear ink with UV light to form a clear ink layer. The clear ink includes about 38 wt % to about 70 wt % of a polymer binder. The method further includes, applying, via pad printing, at least one pigmented layer onto the cured clear ink layer, and curing the at least one pigmented layer with UV light to form a lens assembly.

Abstract: The invention provides a method for making silicone hydrogel contact lenses in a relatively efficient and consistent manner from a lens formulation (i.e., a polymerizable composition) including a thermal initiator having a 10-hour half-life temperature (T10h?) under a controlled thermal curing scheme. A method of the invention comprises a step of curing the lens formulation in an oven according to a thermal curing profile that comprises or consists essentially of increasing the oven's temperature from room temperature or a temperature that is at least about 5° C. lower than T10h? to a temperature that is at least 30° C. higher than T10h? at a selected rate (e.g., from about 1° C./minute to about 10° C./minute). Under such a controlled thermal curing scheme, the lens diameter of the fully-hydrated silicone hydrogel contact lenses obtained according to a method of the invention does not vary significantly with the positions of the molds in the oven.

Abstract: A method for producing embedded hydrogel contact lenses comprises at least the following steps: obtaining an insert made of a crosslinked polymeric material comprising iniferter moieties covalently attached thereto; placing the insert in a female lens mold half; dosing an amount of a lens-forming composition to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; curing the lens-forming composition in the molding assembly to form an embedded hydrogel lens precursor which comprises a bulk hydrogel material formed the lens-forming composition and the insert that is embedded therein and covalently linked to the bulk hydrogel material.

Abstract: A method for producing embedded hydrogel contact lenses comprises at least the following steps: obtaining an insert made of a crosslinked polymeric material comprising iniferter moieties covalently attached thereto; placing the insert in a female lens mold half; dosing an amount of a lens-forming composition to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; curing the lens-forming composition in the molding assembly to form an embedded hydrogel lens precursor which comprises a bulk hydrogel material formed the lens-forming composition and the insert that is embedded therein and covalently linked to the bulk hydrogel material.

Abstract: The present invention is related to reactive dyes each of which comprises a dichlorotriazine, chlorotriazine or vinylsulphonyl group and is capable of absorbing HEVL. They are suitable for method for producing colored silicone hydrogel contact lenses each made of a silicone hydrogel material having hydroxyl groups. The present invention is also related to a colored silicone hydrogel contact lens comprising a colored circular region in which a reactive dye is applied and thereby covalently attached.

Abstract: Described herein is a method for producing centrally colored silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a hydroxyl-containing polymerizable component to form an unprocessed silicone hydrogel contact lens having hydroxyl groups covalently incorporated into its polymer matrix and steps of applying and fixing a reactive dye to the polymer matrix only in its central circular region concentric with the central axis of the unprocessed silicone hydrogel contact lens. The obtained centrally colored silicone hydrogel contact lens has a central circular region that is only colored to selectively filter radiations of certain wavelengths, e.g., HEVL.

Abstract: A method for producing embedded hydrogel contact lenses comprises at least the following steps: obtaining an insert made of a crosslinked polymeric material comprising repeating units of a free-radical photoinitiator; placing the insert in a female lens mold half; dosing an amount of a lens-forming composition to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; actinically curing both the lens-forming composition in the molding assembly to form an embedded hydrogel lens precursor which comprises a bulk hydrogel material formed the lens-forming composition and the insert that is embedded therein and covalently linked to the bulk hydrogel material.

Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermaly or acctinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

Abstract: A method for producing embedded hydrogel contact lenses comprises at least the following steps: obtaining an insert made of a crosslinked polymeric material comprising repeating units of a free-radical photoinitiator; placing the insert in a female lens mold half; dosing an amount of a lens-forming composition to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; actinically curing both the lens-forming composition in the molding assembly to form an embedded hydrogel lens precursor which comprises a bulk hydrogel material formed the lens-forming composition and the insert that is embedded therein and covalently linked to the bulk hydrogel material.

Abstract: Disclosed are an endoscope forceps elevator, an endoscope distal end and a duodenoscope system. The bottom of the endoscope forceps elevator is in communication with an instrument channel and the endoscope forceps elevator is provided with a hinge part configured to be hinged with an endoscope distal end base; a positioning groove adapted to an instrument to be positioned is provided at the top of the endoscope forceps elevator; and a cutting edge and a guide surface are provided at a side of the endoscope forceps elevator, and the guide surface is located between the positioning groove and the cutting edge. The cutting edge is movable in contact with the inner side surface of the distal end base so as to guide the instrument to be positioned in a first deflected and extended state onto the guide surface.

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

Abstract: Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

Abstract: The invention provides a method for producing embedded contact lenses involving steps of use of a set of 3 mold halves in two-curing steps. One of the 3 mold halves have been used twice, the first time for molding an insert and the second time for molding the embedded hydrogel contact lens. The twice-used mold half has been treated with a corona plasma or a vacuum UV in a central circular area of its molding surface having a diameter equal to or smaller than the diameter of the insert to ensure that the molded insert consistently adhered to the twice-used mold half. The method also comprises a step of forming a reactive polysiloxane coating that is covalently attached onto the back or front surface of a molded insert adhered on the twice-used mold half before molding the embedded contact lens in the 2nd curing step.

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner.

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises treating the molding surfaces of polypropylene lens molds (or other hydrophobic plastic molds) with a vacuum UV or a corona plasma to increase the surface energies of the molding surfaces of the lens molds, cast-molding a silicone hydrogel lens formulation containing a relatively small amount of at least one carboxyl-containing vinylic monomer in the treated lens molds, and heating resultant cast-molded silicone hydrogel contact lenses in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel layer covalently attached onto the bulk silicone hydrogel material.