Abstract: Various implementations disclosed herein include devices, systems, and methods that generate floorplans and measurements using a three-dimensional (3D) representation of a physical environment generated based on sensor data.

Abstract: A method and a device for fault diagnosis of wind turbine pitch bearing based on neural network, the method includes: measuring the signal strength at different points of a sensor and different rolling angles, determining an optimal measurement rolling angle of a blade and sensor point arrangement, blocking the blade at the optimal rolling angle to collect the pitch vibration data, further processing the collected vibration data into a dataset, constructing a neural network model, using the collected dataset to train the network, and deploying the trained network to PLC for real-time dynamic monitoring of the wind turbine; the device includes the vibration acceleration sensors, a vibration data acquisition card and a programmable logic controller (PLC). The present disclosure can realize the fast, real-time and accurate monitoring of the health status of the pitch bearing.

Abstract: An anti-human PD-L1 nanobody and use thereof, and an anti-human PD-L1 and TLR7 double-targeting nanobody conjugate drug, a preparation method therefor and use thereof are provided. Specifically, provided are use and a solution of an anti-human PD-L1 nanobody and a derivative protein thereof for anti-tumor treatment, and also provided are design, preparation, and identification solutions for a novel anti-human PD-L1 and TLR7 double-targeting nanobody drug conjugate and a derivative molecule thereof and an effect thereof in anti-tumor treatment. The anti-human PD-L1 and TLR7 double-targeting nanobody drug conjugate can exert significant anti-tumor efficacy.

Abstract: The application provides a foldable holder and an electronic device. A bottom plate of the foldable holder is rotationally connected to a first support plate through a first rotating portion, and a second support plate is rotationally connected to the first support plate through a second rotating portion. A clamping portion is mounted on the first support plate and slidable relative to the first support plate. When the foldable holder is in a closed state, the clamping portion clamps the second rotating portion to lock the first support plate and the second support plate, when the first support plate is at an angle to the bottom plate, the clamping portion is unlocked from the second rotating portion and clamped with the first rotating portion, the unlocking of the second rotating portion enables the second support plate to rotate relative to the first support plate.

Abstract: This application provides a foldable support and an electronic device. The foldable support includes a bottom plate, a first support plate, a second support plate, a first magnetic member, and a second magnetic member: the first support plate is connected to the bottom plate; the second support plate is connected to the first support plate; and the first magnetic member is arranged on the first support plate, the second magnetic member is arranged on the second support plate, and the first magnetic member is configured to attract the second magnetic member in a case that an included angle between the first support plate and the bottom plate is less than a preset angle, and is further configured to repel the second magnetic member in a case that the included angle between the first support plate and the bottom plate is greater than or equal to the preset angle.

Abstract: Provided in the present disclosure are a six-membered cyclothiazole compound as represented by formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and the use thereof in the prevention or treatment of diseases mediated by DNA polymerase ?.

Abstract: A full-fiber burner brick and a preparation method thereof, comprising mixing alumina crystal fiber and amorphous ceramic fiber with both of them being a combination of fibers of different lengths gradations, and moreover adding fine powder fillers of different particle size gradations and supplementing other additives. This enables the internal structure of the product more uniform, increases the bulk density of the product, and also benefits the suction filterability of fiber cotton blank, and is conducive to forming and improving the strength of the blank. The surface of the brick body is further provided with a coating, which can effectively protect the cotton fiber of the brick body fiber from harsh environments, improve its high temperature resistance, and help to extend the service life of the burner brick.

Abstract: This application provides a pre-connector and a communications device. The pre-connector includes a connector component and an outdoor component. The connector component includes a ferrule base and a ferrule that is slidable relative to the ferrule base. The ferrule base is configured to fasten the optical cable, and the ferrule is connected to an optical fiber that is of the optical cable and that is inserted into the ferrule base. In this way, the optical fiber can be connected to the communications device by using the ferrule. The outdoor component includes: a spindle that is sleeved on the ferrule base and that is fastened to the ferrule base; and a handle sleeve sleeved on the spindle. The outdoor component is used as a connecting piece to be detachably fastened and connected to the communications device, so as to provide a locking force used when the communications device is connected.

Abstract: Disclosed are an application of a coronavirus SARS-CoV-2 vaccine polypeptide, a polypeptide composition and a nanoemulsion preparation thereof in the prevention of coronavirus SARS-CoV-2 wild and mutant strain infections. Specifically, provided is a coronavirus SARS-CoV-2 vaccine polypeptide having an amino acid sequence derived from an S protein of SARS-CoV-2 wild and mutant strains, the vaccine polypeptide can enable the body to generate high-level and durable humoral immune responses against SARS-CoV-2 and to produce high titers of RBD-binding antibodies and neutralizing antibodies that block the binding of RBD to ACE2. The vaccine polypeptide can be used to prevent infections of SARS-CoV-2 wild strain and B.1.1.7, B.1.351, B.1.617, B.1.1.529 and other mutant strains.

Abstract: An accurate temperature measurement structure of a wide temperature range includes: a lens set; an optical base, having a neutral density slot and being fixed with the lens set by a first screw; a mask shutter assembly, fixed with the optical base by a second screw; and a temperature sensing unit, for sensing a target object temperature so as to obtain a measured temperature value, the temperature sensing unit performing a temperature normalization correction when the accurate temperature measurement structure of the wide temperature range is in a power-on stage to obtain a signal strength value, setting a plurality of signal conditions according to the signal strength value to obtain a dynamic linearity strength value and accordingly determining an extreme value region, so as to determine whether to add a neutral density filter to the neutral density slot.

Abstract: A front housing of the optical-electrical composite connector is axially provided with a through groove passing through the front housing on the front housing, and an inner wall of the through groove is provided with a first groove. A rear housing includes a main body portion and a clamping portion connected to one end of the main body portion. An outer surface of the clamping portion is axially provided with a second groove, the clamping portion is located in the through groove, and the first groove is butted with the second groove to form an accommodation space. One end that is of the through groove and that is away from the main body portion is an optical port. The font housing is provided with an opening connecting to the accommodation space and the outside. The conductive terminal is accommodated in the opening, and the conductive terminal forms an electrical port.

Abstract: This application provides a foldable support and an electronic device. The foldable support includes a bottom plate, a first support plate, a second support plate, a first magnetic member, and a second magnetic member: the first support plate is connected to the bottom plate; the second support plate is connected to the first support plate; and the first magnetic member is arranged on the first support plate, the second magnetic member is arranged on the second support plate, and the first magnetic member is configured to attract the second magnetic member in a case that an included angle between the first support plate and the bottom plate is less than a preset angle, and is further configured to repel the second magnetic member in a case that the included angle between the first support plate and the bottom plate is greater than or equal to the preset angle.

Abstract: A compound as represented by formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof, a preparation method therefor, and the use thereof in the treatment of tumors, inflammatory diseases or autoimmune diseases.

Abstract: A method for manufacturing a metal shell for casing of electronic product comprises stamping, squeezing and milling a sheet metal at a first area and a second area to form hinge side walls. The sheet metal on the periphery is stamped, squeezed, and milled to form side walls. Insert molding is performed at inner surface of the sheet metal to form an internal molded plastic part and a fine machining of the sheet metal is carried out. The metal shell is integrally formed from a single solid sheet, the manufacturing process is simple and economical as CNC processes are reduced.

Abstract: A front housing of the optical-electrical composite connector is axially provided with a through groove passing through the front housing on the front housing, and an inner wall of the through groove is provided with a first groove. A rear housing includes a main body portion and a clamping portion connected to one end of the main body portion. An outer surface of the clamping portion is axially provided with a second groove, the clamping portion is located in the through groove, and the first groove is butted with the second groove to form an accommodation space. One end that is of the through groove and that is away from the main body portion is an optical port. The font housing is provided with an opening connecting to the accommodation space and the outside. The conductive terminal is accommodated in the opening, and the conductive terminal forms an electrical port.

Abstract: The present invention relates to a novel coronavirus vaccine using a TLR7 agonist conjugated peptide as an antigen and an emulsion as an adjuvant. An antigen polypeptide of the conjugated peptide is a polypeptide derived from an S protein of SARS-COV-2, and the adjuvant is an oil-in-water nanoemulsion containing squalene. The conjugated peptide nanoemulsion vaccine preparation of the present invention is thermally stable, and can induce a high level of protective humoral immune response in a cynomolgus monkey, and the neutralizing antibody titer of antiserum after immunization of cynomolgus monkey is high, such that invasion of wild-type strain and mutant novel coronavirus can be blocked. The vaccine of the present invention has a nearly complete protection effect on the upper and lower respiratory tracts of the cynomolgus monkey in a cynomolgus monkey SARS-COV-2 challenge test.

Abstract: This application provides a pre-connector and a communications device. The pre-connector includes a connector component and an outdoor component. The connector component includes a ferrule base and a ferrule that is slidable relative to the ferrule base. The ferrule base is configured to fasten the optical cable, and the ferrule is connected to an optical fiber that is of the optical cable and that is inserted into the ferrule base. In this way, the optical fiber can be connected to the communications device by using the ferrule. The outdoor component includes: a spindle that is sleeved on the ferrule base and that is fastened to the ferrule base; and a handle sleeve sleeved on the spindle. The outdoor component is used as a connecting piece to be detachably fastened and connected to the communications device, so as to provide a locking force used when the communications device is connected.

Abstract: The present application relates to a disaccharide linker, a disaccharide-small molecule drug conjugate and a sugar chain fixed-point antibody-drug conjugate, a preparation method and the use thereof. The structure of the disaccharide linker is as shown in the following formula I. The present invention provides a new-type fixed-point and quantitative antibody-drug conjugate form, and the stability and cytotoxicity of the antibody-drug conjugate are improved.

Abstract: The application provides a foldable holder and an electronic device. A bottom plate of the foldable holder is rotationally connected to a first support plate through a first rotating portion, and a second support plate is rotationally connected to the first support plate through a second rotating portion. A clamping portion is mounted on the first support plate and slidable relative to the first support plate. When the foldable holder is in a closed state, the clamping portion clamps the second rotating portion to lock the first support plate and the second support plate, when the first support plate is at an angle to the bottom plate, the clamping portion is unlocked from the second rotating portion and clamped with the first rotating portion, the unlocking of the second rotating portion enables the second support plate to rotate relative to the first support plate.

Abstract: Techniques are disclosed relating to biometric authentication, e.g., facial recognition. In some embodiments, a device is configured to verify that image data from a camera unit exhibits a pseudo-random sequence of image capture modes and/or a probing pattern of illumination points (e.g., from lasers in a depth capture mode) before authenticating a user based on recognizing a face in the image data. In some embodiments, a secure circuit may control verification of the sequence and/or the probing pattern. In some embodiments, the secure circuit may verify frame numbers, signatures, and/or nonce values for captured image information. In some embodiments, a device may implement one or more lockout procedures in response to biometric authentication failures. The disclosed techniques may reduce or eliminate the effectiveness of spoofing and/or replay attacks, in some embodiments.