Abstract: Embodiments of the present disclosure provide a clip instrument. The clip instrument may include a tube body; a clip, comprising at least two clamping components; a locking component, releasably connected with the tube body and capable of locking the at least two clamping components; a connection component, slidably connected with the tube body along a first direction and capable of moving relative to the locking component along the first direction.

Abstract: A handle for a medical device is provided. The handle includes a handheld portion, a driving portion, and a plurality of transmission portions configured to be operatively coupled to a plurality of moving components at a distal end of the medical device. The handheld portion is slidably engaged with the driving portion, and the driving portion is switchably connected to at least one of the plurality of transmission portions.

Abstract: Provided are a clip instrument and a control method. The clip instrument includes a clip device, a delivery device, and a control device. The clip device is releasably disposed at a distal end of the delivery device. The control device includes a control wire including first and second control wires. The clip device includes a clip base and a clamping portion including a first clamping portion and a second clamping portion. A distal end of the first control wire is releasably connected to the first clamping portion. A distal end of the second control wire is releasably connected to the second clamping portion. The first and second clamping portions are configured to deflect in the same direction around an axis under an action of the first and/or the second control wire. The axis is perpendicular to a plane where the first and second clamping portions are located.

Abstract: A winding member, including: connection parts; and two conductive sheets arranged opposite each other, where each conductive sheets includes main bodies and a pin, each main body includes a first end and a second end, the first end is connected to the connection part and the second end is connected to the pin, an accommodating space is defined by the connection part and the main body of each conductive sheet opposite each other, where in a mounting direction of the winding member, a height difference between the second end and the connection part is greater than or equal to zero, a total number of the connection parts is same as a total number of the main bodies of each conductive sheet, and the total number of the connection parts is N, and where N is a positive integer.

Abstract: Provided is a self-leveling rotary handling-type multi-autonomous underwater vehicle (AUV) docking and transfer device and its method. The device includes a docking module, a vertical handling module, and a rotary handling module; the docking module includes a rotary platform with a guide frame, and a top surface of the rotary platform is provided with a first clamping device; the vertical handling module is mounted on a side of the docking module; the vertical handling module includes a liftable handling platform, and the handling platform is provided with a locking device and a second clamping device; the rotary handling module is mounted below the docking module; the rotary handling module includes a multi-branch rotating shaft and a horizontal plate mounted on each branch rotating shaft; and the horizontal plate is arranged with an AUV charging and information interaction device and a third clamping device.

Abstract: Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides a new generation regulatable fusogenic oncolytic herpes simplex virus-1 that is more effective at selective killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic virus described herein is suitable for treatment of solid tumors, as well as other cancers.

Abstract: Provided herein are recombinant Herpes Simplex Virus-2 comprising sequences encoding glycoprotein D and B antigens, with two sequences encoding dominant negative UL9 proteins, compositions comprising the same, and methods of use thereof.

Abstract: The present disclosure provides a clip device. The clip device may include a clip and a storage tube. The clip may include clip arms including a first clip arm and a second clip arm; the storage tube including a channel, a proximal end of the first clip arm, and a proximal end of the second clip arm being stowable within the channel; the clip being capable of being switched from a locked state to an unlocked state; wherein in the locked state, the distal end of the first clip arm and the distal end of the second clip arm are closed and the storage tube restricts a movement of the clip relative to the storage tube toward the distal end of the first clip arm and the distal end of the second clip arm; in the unlocked state, a movement restriction of the clip by the storage tube is released and the distal end of the first clip arm and the distal end of the second clip arm are able to be reopened.

Abstract: The present disclosure relates to systems and methods for positioning a region of interest (ROI). The systems may obtain an image of an object captured by an imaging device. The systems may extract image information of the image. The systems may obtain feature information of a region of interest (ROI) in the object. The systems may determine position information of the ROI in the image using a positioning model based on the image information of the image and the feature information of the ROI.

Abstract: Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides a method for treating cancer comprising administering to a subject in need thereof a checkpoint inhibitor in combination with a new generation regulatable fusogenic oncolytic herpes simplex virus-1 that is more effective at selective killing target cells, such as tumor cells. In various embodiments presented herein, the methods described herein is suitable for treatment of solid tumors, as well as other cancers.

Abstract: The present disclosure provides a clip device. The clip device may include a clip and a storage tube. The clip may include clip arms including a first clip arm and a second clip arm; the storage tube including a channel, a proximal end of the first clip arm, and a proximal end of the second clip arm being stowable within the channel; the clip being capable of being switched from a locked state to an unlocked state; wherein in the locked state, the distal end of the first clip arm and the distal end of the second clip arm are closed and the storage tube restricts a movement of the clip relative to the storage tube toward the distal end of the first clip arm and the distal end of the second clip arm; in the unlocked state, a movement restriction of the clip by the storage tube is released and the distal end of the first clip arm and the distal end of the second clip arm are able to be reopened.

Abstract: The present invention discloses a preparation method of compound total-nutrient and healthy dried Passiflora edulis Sims, comprising: (1) selecting fruit; (2) cleaning, digging a fruit pulp, and removing a fruit peel; (3) pressing the fruit pulp; (4) crushing the flesh; (5) mixing the Passiflora edulis Sims juice, the Passiflora edulis Sims slurry, liquid sugar or powdered sugar or high fructose syrup, apple juice or grape juice or lemon juice, adding citric acid and stirring; (6) pouring the Passiflora edulis Sims composite slurry into a mold, drying, removing the mold, sprinkling fine powdered sugar, and packaging to obtain dried Passiflora edulis Sims. The dried Passiflora edulis Sims in the present invention has aromatic flavor, good taste, sweet and sour taste, comprehensive and balanced nutrition, long shelf life, convenience in eating and suitability for all kinds of people to eat.

Abstract: An electro-static discharge (ESD) protection apparatus is connected to a pin of a chip, and includes: an ESD protective semiconductor device including a drain electrode connected to the pin and a source electrode connected to a reference ground, and configured to discharge a current on the pin; and a comparator circuit, connected between the pin and a gate electrode of the ESD protective semiconductor device, and configured to: acquire a voltage on the pin to obtain a voltage signal, compare the voltage signal with a reference signal of a negative voltage, and control an on-state of the ESD protective semiconductor device according to a comparison result. When the voltage signal is less than the reference signal, a channel between the source electrode and the drain electrode of the ESD protective semiconductor device is opened by the comparator circuit.

Abstract: Systems and methods for determining a target area relating to a subject situated on a table of a medical system are provided. The medical system may include a first device of a first modality and a second device of a second modality. In some embodiments, the system may: identify a second target area relating to the subject for performing a second operation using the second device; determine, based on the second target area, an initial target area relating to the subject for performing a first operation using the first device; and determine a first target area relating to the subject for performing the first operation using the first device by adjusting the initial target area.

Abstract: Provided herein are Vero cell lines that stably express Herpes Simplex Virus (HSV) ICP0 protein. These cells have the same morphology of Vero cells, exhibit stable expression of HSV ICP0 protein, and also efficiently complement replication of HSV ICP0 deficient virus for greater than 20, 30, or even 40 cell passages.

Abstract: In a communication control method, a maximum RB resource that can be currently allocated by a to-be-tested base station is allocated to a terminal device communicating with the to-be-tested base station. Then a MAC layer network transmission rate of the to-be-tested base station is monitored to determine whether an event of transmitting data at a maximum network transmission rate occurs. If the event of transmitting data at the maximum network transmission rate occurs on the to-be-tested base station, it indicates that a network transmission function of the to-be-tested base station is normal.

Abstract: Provided herein are Vero cell lines that stably express Herpes Simplex Virus (HSV) ICP0 protein. These cells have the same morphology of Vero cells, exhibit stable expression of HSV ICP0 protein, and also efficiently complement replication of HSV ICP0 deficient virus for greater than 20, 30, or even 40 cell passages.

Abstract: The present disclosure relates to systems and methods for positioning a region of interest (ROI). The systems may obtain an image of an object captured by an imaging device. The systems may extract image information of the image. The systems may obtain feature information of a region of interest (ROI) in the object. The systems may determine position information of the ROI in the image using a positioning model based on the image information of the image and the feature information of the ROI.

Abstract: The present disclosure relates to systems and methods for positioning a region of interest (ROI). The systems may obtain an image of an object captured by an imaging device. The systems may extract image information of the image. The systems may obtain feature information of a region of interest (ROI) in the object. The systems may determine position information of the ROI in the image using a positioning model based on the image information of the image and the feature information of the ROI.

Abstract: Provided is a liquid sample sampling device used in an operation, and belongs to the technical field of sampling devices. The sampling device includes a negative pressure suction head, an auxiliary tube connected with a side wall of the negative pressure suction head, and a sampling bottle connected with the auxiliary tube. A rebound connecting plate is arranged at a position connecting the negative suction head and the auxiliary tube. The side wall of the negative pressure suction head is provided with a push switch. A diameter of the auxiliary tube is larger than a diameter of the negative pressure suction head. The push switch is an elastic membrane switch.