Abstract: A semiconductor structure, comprising a redistribution layer (RDL) including a dielectric layer and a conductive trace within the dielectric layer; a first conductive member disposed over the RDL and electrically connected with the conductive trace; a second conductive member disposed over the RDL and electrically connected with the conductive trace; a first die disposed over the RDL; a second die disposed over the first die, the first conductive member and the second conductive member; and a connector disposed between the second die and the second conductive member to electrically connect the second die with the conductive trace, wherein the first conductive member is electrically isolated from the second die.

Abstract: An ultrasound stimulation helmet (100) configured to regulate an endogenous neurotrophic factor in a brain or expression of proteins related to a neurodegenerative disease comprises: a main body (1) having a forehead perimeter adjustment knob (12), a back head perimeter adjustment knob (13), a fastening support frame (14), and multiple position adjustment knobs (15); and multiple ultrasound probes (2) detachably mounted on the main body (1), wherein the ultrasound probe (2) has a frequency adjustment button and an intensity adjustment button to respectively control an output frequency and output intensity of the ultrasound probe (2), and other ultrasound parameters and an angle of the ultrasound probe (2) itself are adjustable as well.

Abstract: An ultrasound stimulation helmet (100) configured to regulate an endogenous neurotrophic factor in a brain or expression of proteins related to a neurodegenerative disease comprises: a main body (1) having a forehead perimeter adjustment knob (12), a back head perimeter adjustment knob (13), a fastening support frame (14), and multiple position adjustment knobs (15); and multiple ultrasound probes (2) detachably mounted on the main body (1), wherein the ultrasound probe (2) has a frequency adjustment button and an intensity adjustment button to respectively control an output frequency and output intensity of the ultrasound probe (2), and other ultrasound parameters and an angle of the ultrasound probe (2) itself are adjustable as well.

Abstract: The present invention relates to a blood-brain barrier recovery curve assessment method which uses a focused ultrasound dynamic contrast-enhanced MRI technique, in order to obtain a permeability constant of drug. Furthermore, the present invention, using a double exponential distribution function mathematical model, can estimate the actual physiological recovery curve of the blood-brain barrier. Meanwhile, the present invention also provides a monitoring system for the blood-brain barrier permeability.

Abstract: This present invention discloses a method for treating and/or preventing neurodegenerative diseases by applying low-intensity pulsed ultrasound (LIPUS) stimulation. In addition, this present invention discloses the LIPUS increases neurotrophic factor protein expression, improves cognitive dysfunction and reduces brain damage in neurotoxicity.

Abstract: The present invention provides an ultrasound-mediated drug delivery method for administering a compound to a targeted tissue, and the method at least comprises the following steps: First, an ultrasound apparatus is provided. The compound is then administered to the targeted tissue. A sonication is performed by the ultrasound apparatus to a blood vessel of the targeted tissue after the administration of the compound, and the sonication is capable of enhancing the permeability of the blood vessel to allow the administration of the compound to the targeted tissue. An ultrasound-mediated drug delivery system is also disclosed here.

Abstract: The present invention relates to a blood-brain barrier recovery curve assessment method which uses a focused ultrasound dynamic contrast-enhanced MRI technique, in order to obtain a permeability constant of drug. Furthermore, the present invention, using a double exponential distribution function mathematical model, can estimate the actual physiological recovery curve of the blood-brain barrier. Meanwhile, the present invention also provides a monitoring system for the blood-brain barrier permeability.

Abstract: The present invention provides an ultrasound-mediated drug delivery method for administering a compound to a targeted tissue, and the method at least comprises the following steps: First, an ultrasound apparatus is provided. The compound is then administered to the targeted tissue. A sonication is performed by the ultrasound apparatus to a blood vessel of the targeted tissue after the administration of the compound, and the sonication is capable of enhancing the permeability of the blood vessel to allow the administration of the compound to the targeted tissue. An ultrasound-mediated drug delivery system is also disclosed here.

Abstract: The present invention provides a synchronic monitor system using real-time ultrasound image to monitor the permeable concentration of the targeted tissue for drug delivery induced by ultrasound. The drug delivery is performed by using a first ultrasound apparatus to emit a first ultrasound to a blood vessel of the targeted tissue to allow a drug passing through the blood vessel into a lesion zone. The synchronic monitor system comprises a second ultrasound apparatus and software. The second ultrasound apparatus has a transducer, and the transducer is used to emit a second ultrasound to the blood vessel to determine several information of the blood flow. The software is installed in the second ultrasound apparatus to collect the information of the blood flow, and calculate an extravasation of the drug in the lesion zone according to the information of the blood flow via a first equation. The present invention discloses a method using the same.

Abstract: A method and apparatus for dispensing fluids includes first and second fluid pumps coupled with a source of the fluid. Each of the pumps includes a flow switch for sensing output flow from the associated pump. When one of the pumps malfunctions, the associated flow switch produces a fault signal which triggers a controller to activate the second pump to complete the dispensing of a dose of fluid from the source. A timer measures the duration of the flow from each of the pumps so that a full dose of fluid is dispensed from the two pumps in the event that one of the pumps malfunctions.

Abstract: Within a method for electrical test testing a series of microelectronic fabrication die fabricated within a microelectronic fabrication substrate, there is first electrical probe tested the series of microelectronic fabrication die to determine at least one sub-series of electrically unacceptable microelectronic fabrication die. Each electrically unacceptable microelectronic fabrication die within the series of electrically unacceptable microelectronic fabrication die is then electrical probe retested after having repositioned an electrical probe head with respect to the electrically unacceptable microelectronic fabrication die.

Abstract: A method and an apparatus for calibrating a dissolved oxygen analyzer are disclosed. In the method, a zero point is first determined and set on the analyzer by filling into the analyzer a saturated aqueous solution of an oxidizer that contains 0 ppb oxygen. A span point is then set on the analyzer by filling a sample solution in the analyzer and flowing a cell current through a Faraday electrode until a 20 ppb oxygen is produced and then setting the point as a span point for completing a two-point calibration process. A slope for calibration can be obtained between the zero point and the span point.

Abstract: An apparatus and a method for determining concentration of fluorine ions in aqueous solutions are provided. In the apparatus, a pH sensor is provided for sensing a pH value of an aqueous solution to be determined. A pH controller is then used to compare the pH value determined with stored pH data to determine whether the aqueous solution is acidic or alkalinic. An acid dispenser or a base dispenser is then used to dispense either an acid or a base into the pH adjustment tank for adjusting the pH value of the aqueous solution to within a desirable range. For instance, for the detection of fluorine ions, a suitable pH range is between about 4 and about 10. After the pH value is stabilized in the aqueous solution, a fluorine ion sensor may be used to sense the fluorine ion concentration in the aqueous solution. A common acid and base which may be used to bring the pH value within the desirable range may be H2SO4 and NaOH.