Patents by Inventor Fengfeng Guo

Fengfeng Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE SYNTHESIS OF PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS
    Publication number: 20250101006
    Abstract: The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.
    Type: Application
    Filed: January 30, 2023
    Publication date: March 27, 2025
    Inventors: Markus BAENZIGER, Fabrice GALLOU, Fengfeng GUO, Rudolf HÄNGGI, Enjian HAN, Guido JORDINE, Jialiang LI, Weipeng LIU, Bukeyan MIAO, Shaofeng RONG, Ernesto SANTANDREA, Paul Bernd SCHIRNER, Xiaodong SHEN, Can WANG, Hao ZHANG
  • COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CORONAVIRAL RELATED DISEASES
    Publication number: 20250092016
    Abstract: Provided herein are compounds and compositions for treating, managing or preventing coronaviral related diseases. In particular, provided herein are compounds which are inhibitors of SARS-CoV-2 main protease (Mpro), pharmaceutical compositions comprising such compounds, method for synthesizing such compounds and methods of using such compounds and compositions for the treatment, management or prevention of coronaviral related diseases.
    Type: Application
    Filed: July 20, 2022
    Publication date: March 20, 2025
    Inventors: Denghui BAO, Fengfeng GUO, Matthew James HESSE, Viktor HORNAK, Sajan JOSEPH, Thomas Martin KIRRANE, JR., Haiyao LIN, Bo LIU, Yanan MIAO, Heinz Ernst MOSER, Julien PAPILLON, Yang QU, Lei SHI, Jun YUAN, Teng ZHANG
  • FATTY ACID-BIFUNCTIONAL DEGRADER CONJUGATES AND THEIR METHODS OF USE
    Publication number: 20240216513
    Abstract: Described herein are fatty acid-bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.
    Type: Application
    Filed: March 10, 2022
    Publication date: July 4, 2024
    Inventors: Claire Adcock, Valerie Broennimann, Jiashun Cheng, Rohit Kumar Duvadie, Tanzina Fazal, Jinhai Gao, Fengfeng Guo, Robert Martin Grotzfeld, Christina Hebach, Gregory John Hollingworth, Darryl Brynley Jones, Alexei Karpov, Jialiang Li, Julien Lorber, Chester A. Metcalf, III, Walter Michael, Mark Gabriel Palermo, Scott Vaughan Plummer, James Harold Roache, Martin Sendzik, Ranny Mathew Thomas, Aimee Richardson Usera, Anna Vulpetti, Frederic Zecri, Liang Zhao, Thomas Zoller