Abstract: An intelligent back support device, backrest assembly, and an aircraft seat having the back support device installed are disclosed. The back support device includes: a pressure-sensing apparatus for attachment to a backrest of a chair for detecting pressure received in a plurality of regions of a backrest surface of the backrest; a back support device for attachment to the backrest, the back support device configured to displace a portion of the backrest surface based on the pressure detected in at least one of the plurality of regions of the backrest surface; and a controller device connected to the pressure-sensing apparatus and the back support device, the controller configured to control the back support device.

Abstract: The present invention belongs to the field of pharmaceutical and chemical engineering, and relates to a high-purity losartan potassium and a preparation method therefor. The present invention also relates to a high-purity losartan or a pharmaceutically acceptable salt thereof and a preparation method therefor. The present invention uses organic phosphorus to reduce an azide compound to an amino compound so that the genotoxicity of losartan or a pharmaceutically acceptable salt thereof can be well controlled. The method of the present invention involves fewer steps, uses a small amount of reagent, does not require activated carbon decolorization, and produces a high-purity product, and therefore is suitable for industrial production and is very practical.

Abstract: The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

Abstract: Provided herein are compounds and compositions for treating, managing or preventing coronaviral related diseases. In particular, provided herein are compounds which are inhibitors of SARS-CoV-2 main protease (Mpro), pharmaceutical compositions comprising such compounds, method for synthesizing such compounds and methods of using such compounds and compositions for the treatment, management or prevention of coronaviral related diseases.

Abstract: The present application relates to sequences that enhance permeation of immunotherapy agents across the blood brain barrier, compositions comprising the sequences, and methods of use thereof to treat brain cancer, e.g., glioblastoma (GBM).

Abstract: A high-quality (RS)-?-ethyl-2-oxo-1-pyrrolidine acetic acid acquired by racemization recovery is provided. A method provided significantly increases the quality and appearance of the product (RS)-?-ethyl-2-oxo-1-pyrrolidine acetic acid recovered using racemization and does not affect the product yield.

Abstract: Disclosed in the present invention is a method for preparing high-purity losartan, which belongs to the fields of medicine and chemical engineering. The losartan is obtained by means of a multi-stage temperature reaction in the presence of a catalyst and sodium azide, wherein the temperature in the first stage of the multi-stage temperature reaction is higher than that in the second stage. According to the method, the generation of dimer impurities can be reduced, and the risk of impurities being introduced into a finished losartan potassium product is reduced.

Abstract: A method for detecting and tracking target object in a captured video using convolutional neural network (CNN) is provided. The method includes: inputting image data into a detecting model to generate detection results, wherein the detecting model is constructed by the CNN; inputting the image data into tracking models to generate tracking results; performing detection score enhancement operation according to the detection results and the tracking results to obtain enhanced detection results; matching the enhanced detection results and the tracking results by a matching operation; processing matched results and unmatched target detection results and unmatched target tracking results; and selectively updating the tracking models using tracking reliability estimation according to the matched results.

Abstract: A silicon-based anode material for secondary batteries, a preparation method thereof and a secondary battery are provided. The silicon-based anode material includes: an inner core including an Si particle and silicon oxide SiOx1, where 0<x1<2, a first shell layer including a compound of the general formula MySiOz (0<y?4, 0<z?5, and z?x1) and a C particle, wherein the first shell layer covers the inner core, and the contents of M and C in the first shell layer gradually increase from a side thereof close to the inner core to another side thereof far away from the inner core; and a second shell layer including a carbon film layer or a composite film layer formed by a carbon film layer and a conductive additive, the second shell layer covers the first shell layer. The first charge-discharge cycle capability of the silicon-based anode material is improved, and the manufacturing cost is reduced.

Abstract: Disclosed are a metasurface-based structured light 3D imaging system and method, which use a metasurface-based control device to realize high-quality control of a laser beam, use a MEMS micromirror to scan and project the laser beam, and realize high-precision reconstruction of 3D information of the surface of an object together with related structured light design and demodulation methods. The invention realizes fine control of a structured light, improves the quality of a structured light field, reduces laser speckles and improves power, thus improving 3D imaging precision and robustness.

Abstract: Disclosed are a metasurface-based structured light 3D imaging system and method, which use a metasurface-based control device to realize high-quality control of a laser beam, use a MEMS micromirror to scan and project the laser beam, and realize high-precision reconstruction of 3D information of the surface of an object together with related structured light design and demodulation methods. The invention realizes fine control of a structured light, improves the quality of a structured light field, reduces laser speckles and improves power, thus improving 3D imaging precision and robustness.

Abstract: A machine and its associated process for upset forging the ends of deformed reinforcement bars are disclosed. The machine includes 2 split clamping dies and an upsetting die, and they are housed in separate casings so that the clamping action is independent from the upsetting die. The clamping dies and the upsetting die form a continuous cavity for accommodating the forging of long bars. The upsetting die has a upsetting cavity with radial closed cross-section, and the whole forging process is performed inside this closed cavity to ensure it's a true closed-die forging process, which results in precise upset diameter with improved roundness of the rebar.

Abstract: The present disclosure describes a signal transmission device based on molded interconnect device and laser direct structuring (MID/LDS) technology, comprising: a shielding shell (1); and a photoelectric conversion module (2), which includes a carrier (21), an electrical module (22) and an optical module (23). The photoelectric conversion module (2) is fixed inside the shielding shell (1), wherein the first recessed structure (201) accommodates a driving chip (211), a photoelectric conversion chip (212) and an optical module (23), and the second recessed structure (202) accommodates an electrical module (22), the driving chip (211), the photoelectric conversion chip (212) and the conductive terminal (215) are electrically connected to each other, and the carrier (21) is designed by integral molding based on the MID/LDS technology. In t present disclosure, the design space in the shielding shell can be effectively saved.

Abstract: Described herein are compositions and methods for tissue-targeted expression of therapeutic genes, using AAV expression vectors that reduce the risk of toxicity associated with AAV gene therapy in the CNS by de-targeting the vulnerable neurons cells including the DRG cells on gene expression, and de-targeting the liver, a major suspect for over-expression in the periphery.

Abstract: The present invention relates to a method for manufacturing a toilet blank. The manufacturing method includes the following steps: a grouting step: producing a seat blank, an inner container blank and a main body blank; a first demolding step: demolding a part of a main body mold, a part of an inner container mold and a part of a seat mold; a first bonding step: bonding a first bonding surface of the inner container blank and a bonding surface of the main body blank to each other; a second demolding step: demolding another part of the inner container mold from the inner container blank; a second bonding step: bonding a bonding surface of the seat blank and a second bonding surface of the inner container blank to each other, and a third demolding step: demolding demolded parts of the seat mold, the inner container mold and the main body mold from a bonded toilet blank.

Abstract: A machine and its associated process for upset forging the ends of deformed reinforcement bars are disclosed. The machine includes 2 split clamping dies and an upsetting die, and they are housed in separate casings so that the clamping action is independent from the upsetting die. The clamping dies and the upsetting die form a continuous cavity for accommodating the forging of long bars. The upsetting die has a upsetting cavity with radial closed cross-section, and the whole forging process is performed inside this closed cavity to ensure it's a true closed-die forging process, which results in precise upset diameter with improved roundness of the rebar.

Abstract: Described herein are fatty acid-bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.

Abstract: The present disclosure belongs to the technical field of computers, in particular relates to a novel computer architecture system and a control method therefor. The computer architecture system includes a host, wherein the host includes a CPU master control unit, an EC unit, a first interface unit and a battery; the EC unit is electrically connected to the CPU master control unit and the first interface unit, respectively; and the battery is electrically connected to the CPU master control unit.

Abstract: The present application relates to sequences that enhance permeation of immunotherapy agents across the blood brain barrier (BBB), compositions comprising the sequences, and methods of use thereof to treat brain cancer, e.g., glioblastoma (GBM). Further disclosed are a number of potential targeting peptide sequences identified that enhance permeation through the BBB, when inserted into the capsid of an adeno-associated virus (AAV).