Abstract: Related are a novel antibody specifically binding with B7-H3, an antigen-binding fragment of the antibody, and a composition comprising the antibody or the antigen-binding fragment thereof. Related are nucleic acids encoding the antibody or the antigen-binding fragment thereof, a host cell comprising the nucleic acids, and relevant uses. In addition, related are therapeutic and diagnostic uses of the antibody and the antigen-binding fragment thereof.

Abstract: The present invention relates to a novel interleukin-21 (IL-21) mutant protein and use thereof. In particular, the present invention relates to an IL-21 mutant protein that has improved properties, such as a reduced binding property to an IL-21 receptor and improved druggability, compared to wild-type IL-21. The present invention also provides a fusion comprising the IL-21 mutant protein, a nucleic acid encoding the IL-21 mutant protein or the fusion, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-21 mutant protein or the fusion, a pharmaceutical composition comprising the same, and therapeutic use.

Abstract: The present invention relates to novel proteins containing heterodimeric antibody Fc such as bispecific antibodies, and novel methods for preparing such proteins.

Abstract: A novel antibody and antibody fragment specifically biding to CD3, and composition comprising the antibody or antibody fragment. Nucleic acids encoding the antibody or the antibody fragment thereof, a host cell comprising the nucleic acids, relevant uses, and therapeutic and diagnostic uses of the antibody and of the antibody fragment.

Abstract: The present invention relates to a novel interleukin-2 (IL-2) mutant protein. The present invention further provides a fusion protein and an immunoconjugate comprising the IL-2 mutant protein, a nucleic acid encoding the IL-2 mutant protein, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-2 mutant protein, a pharmaceutical composition comprising the IL-2 mutant protein, and therapeutic use of the mutant protein.

Abstract: The present invention relates to a novel interleukin-2 (IL-2) mutant protein. The present invention also provides a fusion protein, a dimeric molecule and an immunoconjugate comprising the IL-2 mutant protein, as well as a nucleic acid encoding same, a vector and a host cell comprising the nucleic acid, a pharmaceutical composition comprising same and therapeutic use. The present invention further provides a method for preparing the IL-2 mutant protein, the fusion protein, the dimeric molecule and the immunoconjugate.

Abstract: The present invention relates to a novel interleukin-2 (IL-2) mutant protein and use thereof. In particular, the present invention relates to an IL-2 mutant protein with reduced IL-2R? receptor binding ability and/or increased IL-2R? receptor binding ability compared with the wild-type IL-2. The present invention further provides a fusion protein and an immunoconjugate comprising the IL-2 mutant protein, a nucleic acid encoding the IL-2 mutant protein, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-2 mutant protein, a pharmaceutical composition comprising the IL-2 mutant protein, and therapeutic use of the mutant protein.

Abstract: The present invention relates to a novel interleukin-2 (IL-2) mutant protein. The present invention further provides a fusion protein and an immunoconjugate comprising the IL-2 mutant protein, a nucleic acid encoding the IL-2 mutant protein, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-2 mutant protein, a pharmaceutical composition comprising the IL-2 mutant protein, and therapeutic use of the mutant protein.