Patents by Inventor Fenghao LIU

Fenghao LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12116342
    Abstract: The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: October 15, 2024
    Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.
    Inventors: Haisheng Fan, Yipeng Zhan, Kai Yin, Xiang Ji, Fenghao Liu, Kaiqiang Shi, Xiaowen Guo, Luning Huang, Anping Tao, Jianguo An, Hong Gu
  • Publication number: 20220048856
    Abstract: The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 17, 2022
    Inventors: Haisheng FAN, Yipeng ZHAN, Kai YIN, Xiang JI, Fenghao LIU, Kaiqiang SHI, Xiaowen GUO, Luning HUANG, Anping TAO, Jianguo AN, Hong GU