Abstract: The present invention relates to the field of biomedicine, and specifically relates to a proteolysis-targeting chimera (PROTAC) compound. The structure of the PROTAC compound can be represented by general formula LGP-LK-LGE, wherein LGP is a ligand for binding a deoxyribonucleic acid (DNA) polymerase; LGE is a ligand for binding an E3 ubiquitin ligase; and LK is a linker linking the two above ligands. The compound prevents virus replication and kills viruses by means of degrading a deoxyribonucleic acid (DNA) polymerase that inhibits the viruses, and thus performs the function of treating and intervening in viral infectious diseases such as hepatitis B and secondary diseases, and the acquired immunodeficiency syndrome.

Abstract: A method and device for detecting inflammation activity of a tissue. The method includes: determining whether there is a possibility for tissue inflammation; and when there is a possibility for tissue inflammation, determining the inflammation activity of a tissue according to tissue stiffness or a parameter reflecting tissue stiffness. The tissue stiffness or the parameter reflecting tissue stiffness can be detected by means of a non-invasive quantitative detection technique of tissue elastic modulus, avoiding defects caused by tissue biopsy, and can detect inflammation activity of a tissue non-invasively, continuously and accurately.

Abstract: A method and device for detecting inflammation activity of a tissue. The method includes: determining whether there is a possibility for tissue inflammation; and when there is a possibility for tissue inflammation, determining the inflammation activity of a tissue according to tissue stiffness or a parameter reflecting tissue stiffness. The tissue stiffness or the parameter reflecting tissue stiffness can be detected by means of a non-invasive quantitative detection technique of tissue elastic modulus, avoiding defects caused by tissue biopsy, and can detect inflammation activity of a tissue non-invasively, continuously and accurately.

Abstract: A method and device for detecting tissue fibrosis. The method includes: determining whether there is a possibility for tissue inflammation; and when there is a possibility for tissue inflammation, monitoring tissue stiffness or a parameter reflecting tissue stiffness during a treatment of the tissue inflammation to determine whether the tissue inflammation has been eliminated; when the tissue inflammation has been eliminated or there is no possibility for tissue inflammation, obtaining a degree of tissue fibrosis or information related to the degree of tissue fibrosis according to tissue stiffness or a parameter reflecting tissue stiffness. The embodiments enable the tracking of the tissue stiffness during the treatment of tissue inflammation to determine whether tissue inflammation has been eliminated or not, and since tissue stiffness can be detected by a non-invasive quantitative detection technique of tissue elastic modulus, avoiding defects caused by tissue biopsy.

Abstract: The invention relates to the field of diagnosis and treatment of cirrhosis and liver fibrosis. Specifically, the invention relates to the use of Golgi protein 73 (GP73) and a substance of detecting the level of Golgi protein 73 (GP73) for preparing the products for screening, auxiliarily diagnosing liver diseases or auxiliarily determining the prognosis of liver diseases. The invention proves that Golgi protein 73 (GP73) can be used as a novel marker of cirrhosis, and has diagnostic value especially for cirrhosis resulting from non-hepatitis B virus infection, but has no diagnostic value for primary hepatocellular carcinoma.