Patents by Inventor Fengtian Xue

Fengtian Xue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
    Patent number: 9212161
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: December 15, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • Intramolecular Hydrogen-Bonded Nitric Oxide Synthase Inhibitors
    Publication number: 20150252020
    Abstract: Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Application
    Filed: January 5, 2015
    Publication date: September 10, 2015
    Inventors: Richard B. Silverman, Fengtian Xue
  • Specific nNOS inhibitors for the therapy and prevention of human melanoma
    Patent number: 9090589
    Abstract: Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: July 28, 2015
    Assignees: Northwestern University, The Regents of the University of California
    Inventors: Richard B. Silverman, Frank L. Meyskens, Sun Yang, Haitao Ji, Fengtian Xue, Thomas L. Poulos
  • Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
    Patent number: 8932842
    Abstract: Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: January 13, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue, He Huang
  • Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
    Patent number: 8829187
    Abstract: Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: September 9, 2014
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20140228578
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Application
    Filed: April 14, 2014
    Publication date: August 14, 2014
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • Specific nNOS Inhibitors for the Therapy and Prevention of Human Melanoma
    Publication number: 20140147920
    Abstract: Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 29, 2014
    Applicants: The Regents of the University of California, Northwestern University
    Inventors: Frank L. Meyskens, JR., Richard B. Silverman, Sun Yang, Haitao Ji, Fengtian Xue, Thomas L. Poulos
  • Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
    Patent number: 8697879
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 15, 2014
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • Inhibitors of nitric oxide synthase for treatment of melanoma
    Patent number: 8642282
    Abstract: Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: February 4, 2014
    Assignees: Northwestern University, The Regents of the University of California
    Inventors: Frank L. Meyskens, Jr., Richard B. Silverman, Sun Yang, Haitao Ji, Fengtian Xue, Thomas L. Poulos
  • Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
    Patent number: 8389731
    Abstract: Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: March 5, 2013
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability
    Patent number: 8299100
    Abstract: Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and can be employed in the treatment of various neurodegenerative diseases, such compounds of a formula
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: October 30, 2012
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
    Patent number: 8278084
    Abstract: Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: October 2, 2012
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • Specific nNOS Inhibitors for the Therapy And Prevention Of Human Melanoma
    Publication number: 20120238016
    Abstract: Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.
    Type: Application
    Filed: January 12, 2012
    Publication date: September 20, 2012
    Inventors: Frank L. Myskens, JR., Richard B. Silverman, Sun Yang, Haitao Ji, Fengtian Xue, Thomas L. Poulos
  • Intramolecular Hydrogen-Bonded Nitric Oxide Synthase Inhibitors
    Publication number: 20120088798
    Abstract: Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Application
    Filed: September 30, 2011
    Publication date: April 12, 2012
    Inventors: Richard B. Silverman, Fengtian Xue
  • Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20120004415
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Application
    Filed: July 1, 2011
    Publication date: January 5, 2012
    Inventors: Richard B. Silverman, Fengtian Xue
  • Chiral Pyrrolidine Core Compounds en route to Inhibitors of Nitric Oxide Synthase
    Publication number: 20100292484
    Abstract: Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.
    Type: Application
    Filed: May 17, 2010
    Publication date: November 18, 2010
    Inventors: Richard B. Silverman, Fengtian Xue
  • Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition
    Publication number: 20100203613
    Abstract: Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 12, 2010
    Inventors: Richard B. Silverman, Fengtian Xue
  • Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors with Improved Membrane Permeability
    Publication number: 20100190230
    Abstract: Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Application
    Filed: January 25, 2010
    Publication date: July 29, 2010
    Inventors: Richard B. Silverman, Fengtian Xue