Abstract: The present invention belongs to the technical field of biomedicine, and specifically relates to an extracellular cyclophilin inhibitor and the use thereof, wherein the structural general formula of the extracellular cyclophilin inhibitor of the present invention is as shown in formula (I). According to the present invention, a group capable of reacting with sulfhydryl of cysteine at a specific site on blood albumin is extracted by means of a side chain of a new cyclosporin derivative, and a drug conjugate is rapidly formed after same enters the body, which can effectively restrict the drug to the extracellular area and form targeted inhibition of extracellular cyclophilin, thereby achieving the aim of treating diseases associated therewith.

Abstract: The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCH2OCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a CO2 fluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCH2OCOCl solution.

Abstract: The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCH2OCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a CO2 fluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCH2OCOCl solution.

Abstract: An embodiment of the present invention relates to a network access method, system and terminal device, and computer storage medium, the method comprising: providing one or more physical network interfaces on a first terminal device; the first terminal device transmits an address resolution protocol (ARP) request to a second terminal device, the second terminal device being connected to the first terminal device via one of the physical network interfaces; if the first terminal device receives a DHCP discovery packet or a router announcement request within a first pre-set time, then the first terminal device accesses an internal network; if the first terminal device receives a router announcement broadcast within the first pre-set time or did not receive a response within the first preset time, then the first terminal device accesses an external network.

Abstract: An embodiment of the present invention relates to a network access method, system and terminal device, and computer storage medium, the method comprising: providing one or more physical network interfaces on a first terminal device; the first terminal device transmits an address resolution protocol (ARP) request to a second terminal device, the second terminal device being connected to the first terminal device via one of the physical network interfaces; if the first terminal device receives a DHCP discovery packet or a router announcement request within a first pre-set time, then the first terminal device accesses an internal network; if the first terminal device receives a router announcement broadcast within the first pre-set time or did not receive a response within the first preset time, then the first terminal device accesses an external network.