Patents by Inventor Fengyan Yu

Fengyan Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Let-7 microRNA and mimetics thereof as therapeutics for cancer
    Patent number: 11147828
    Abstract: The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. in some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: October 19, 2021
    Assignee: Children's Medical Center Corporation
    Inventors: Judy Lieberman, Erwei Song, Fengyan Yu, Xiaoqu Hu
  • LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER
    Publication number: 20190224228
    Abstract: The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. in some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.
    Type: Application
    Filed: December 6, 2018
    Publication date: July 25, 2019
    Applicant: THE CHILDREN'S HOSPITAL CORPORATION
    Inventors: Judy LIEBERMAN, Erwei SONG, Fengyan YU, Xiaoqu HU
  • LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER
    Publication number: 20140377263
    Abstract: The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.
    Type: Application
    Filed: May 21, 2014
    Publication date: December 25, 2014
    Applicant: The Children's Hospital Corporation
    Inventors: Judy LIEBERMAN, Erwei SONG, Fengyan YU, Xiaoqu HU
  • LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER
    Publication number: 20100310583
    Abstract: The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.
    Type: Application
    Filed: January 31, 2008
    Publication date: December 9, 2010
    Applicant: IMMUNE DISEASE INSTITUTE
    Inventors: Judy Lieberman, Erwei Song, Fengyan Yu, Xiaoqu Hu