Patents by Inventor Fenju LIU

Fenju LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR SCREENING THERAPEUTIC TARGET OF ACUTE GASTROINTESTINAL SYNDROME AND USE OF TIGAR TARGET IN PREPARATION OF MEDICINE FOR TREATING RADIATION-INDUCED GASTROINTESTINAL SYNDROME
    Publication number: 20220317113
    Abstract: The invention discloses a method for screening a therapeutic target of acute radiation-induced gastrointestinal syndrome and use of TIGAR target in the preparation of a medicine for treating radiation-induced gastrointestinal syndrome. The CreERT-loxP transgenic mouse model is used, in which quiescent intestinal crypt stem cells are effectively promoted to proliferate after exposure to high-dose ionizing radiation, to screen a therapeutic target that still has a therapeutic effect for radiation-induced gastrointestinal syndrome 18-24 h after ionizing radiation. Gene splicing occurs in particular cells in the CreERT-loxP transgenic mice only after the injection of tamoxifen, thereby regulating gene expression. The actual situation of initial exposure and then treatment after a nuclear accident is well simulated, so the invention is of great practical significance.
    Type: Application
    Filed: June 28, 2020
    Publication date: October 6, 2022
    Inventors: Haowen ZHANG, Chunlin SHAO, Zhongmin WANG, Yushuo ZHANG, Xiaolin SHI, Chen WANG, Jinlu WANG, Zicheng DENG, Longxin LIN, Fei CHEN, Huangge REN, Qimeng TANG, Haoliang DUAN, Bowen FU, Fenju LIU
  • Method for determining the repair activity of non-homologous end joining
    Patent number: 9863933
    Abstract: The invention discloses a method for determining the repair activity of NHEJ. In this method, HPRT gene is mutated by using a site-directed gene mutation technology, and plasmid transfection, and 6-TG treatment are performed. By means of the method of the invention, the NHEJ repair activity level of cells can be observed by measuring the cell viability. The method can be used for screening the effects of different drugs and different genes on the NHEJ repair activity.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: January 9, 2018
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Fenju Liu, Jie Du, Jiahua Yu, Haowen Zhang, Zengfu Shang, Yushuo Zhang
  • Method for Determining the Repair Activity of Non-Homologous End Joining
    Publication number: 20170254799
    Abstract: The invention discloses a method for determining the repair activity of NHEJ. In this method, HPRT gene is mutated by using a site-directed gene mutation technology, and plasmid transfection, and 6-TG treatment are performed. By means of the method of the invention, the NHEJ repair activity level of cells can be observed by measuring the cell viability. The method can be used for screening the effects of different drugs and different genes on the NHEJ repair activity.
    Type: Application
    Filed: August 18, 2015
    Publication date: September 7, 2017
    Inventors: Fenju LIU, Jie DU, Jiahua YU, Haowen ZHANG, Zengfu SHANG, Yushuo ZHANG