Patents by Inventor Fergal Casey

Fergal Casey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12071661
    Abstract: The invention is a method of predicting response to therapy in a colorectal cancer patient, the method comprising measuring tumor genetic heterogeneity via analysis of circulating tumor DNA from a patients sample.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: August 27, 2024
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Fergal Casey, John J. Lee, John F. Palma, Stephanie J. Yaung
  • Publication number: 20210375391
    Abstract: Methods and systems for detecting MSI are provided. Also provided are methods for enriching human genomic DNA for microsatellite loci. Additional, an oligonucleotide array for detecting MSI is provided.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 2, 2021
    Inventors: Fergal Casey, Daniel M. Klass, Alexander Lovejoy, Seyed Hamid Mirebrahim, Amrita Pati, Hao Wang
  • Publication number: 20210310050
    Abstract: Techniques for identification of global cancer-specific sequence features in whole genome sequence data obtained from cell-free DNA (cfDNA) samples. An exemplary technique includes obtaining a plurality of whole genome sequencing reads from a cfDNA sample and determining two or more metrics from at least a majority of the plurality of genome sequencing reads, where a first metric of the two or more metrics is: (i) a fragment size of the cell free DNA, (ii) relative read depth of the plurality of whole genome sequencing reads, or (iii) germline allelic imbalance. The technique further includes inputting the two or more metrics into a classifier to obtain a first prediction for a first class and a second prediction for a second class, and classifying the sample of cell free DNA as the first class or the second class based on the first prediction and the second prediction.
    Type: Application
    Filed: June 18, 2021
    Publication date: October 7, 2021
    Inventors: Mingyang Cai, Fergal Casey, Liang Feng, Alexander Lovejoy
  • Publication number: 20210002719
    Abstract: The invention is a method of predicting response to therapy in a colorectal cancer patient, the method comprising measuring tumor genetic heterogeneity via analysis of circulating tumor DNA from a patient's sample.
    Type: Application
    Filed: February 11, 2019
    Publication date: January 7, 2021
    Inventors: Fergal Casey, John J. Lee, John F. Palma, Stephanie J. Yaung