Patents by Inventor Fergal Joseph O'Brien

Fergal Joseph O'Brien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Collagen/hydroxyapatite composite scaffold, and process for the production thereof
    Patent number: 9138483
    Abstract: A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilizing the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w). Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3 KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: September 22, 2015
    Assignee: ROYAL COLLEGE OF SURGEONS IN IRELAND
    Inventors: Fergal Joseph O'Brien, John Patrick Gleeson, Niamh Plunkett
  • Collagen/hydroxyapatite composite scaffold, and process for the production thereof
    Patent number: 8435552
    Abstract: A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilizing the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w). Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3 KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: May 7, 2013
    Assignee: Royal College of Surgeons in Ireland
    Inventors: Fergal Joseph O'Brien, John Patrick Gleeson, Niamh Plunkett
  • COLLAGEN/HYDROXYAPATITE COMPOSITE SCAFFOLD, AND PROCESS FOR THE PRODUCTION THEREOF
    Publication number: 20100158976
    Abstract: A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilising the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w). Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3 KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
    Type: Application
    Filed: February 11, 2008
    Publication date: June 24, 2010
    Applicant: ROYAL COLLEGE OF SURGEONS IN IRELAND
    Inventors: Fergal Joseph O'Brien, John Patrick Gleeson, Niamh Plunkett