Abstract: An implantable medical device, and a method of manufacturing the same, the device including a bioresorbable conduit including an exterior surface including one or more weakened areas configured to degrade preferentially to the remainder of the bioresorbable conduit, and an interior surface.

Abstract: A nerve regeneration device comprising a bioresorbable conduit and a matrix contained therein having elongate pores aligned with the longitudinal axis of the conduit. The matrix comprises collagen, fibronectin, laminin-1, and laminin-2, wherein the amount, by weight, of laminin-1 or laminin-2 is greater than the amount of fibronectin in the matrix.

Abstract: A nerve regeneration device comprising a bioresorbable conduit and a matrix contained therein having elongate pores aligned with the longitudinal axis of the conduit. The matrix comprises collagen, fibronectin, laminin-1, and laminin-2, wherein the amount, by weight, of laminin-1 or laminin-2 is greater than the amount of fibronectin in the matrix.

Abstract: The invention relates to a method for representing an environmental region of a motor vehicle in an image, in which real images of the environmental region are captured by a plurality of real cameras of the motor vehicle and the image is generated from these real images, which at least partially represents the environmental region, wherein the image is represented from a perspective of a virtual camera arranged in the environmental region, and the image is generated as a bowl shape, wherein at least one virtual elongated distance marker is represented in the image, by which a distance to the motor vehicle is symbolized in the virtual bowl shape. The invention also relates to a computer program product and a display system for a motor vehicle.

Abstract: The present invention relates to a device for use in the delivery of an active agent. Specifically, the present invention relates to a device comprising a scaffold that can be formed from a polymer or copolymer; a matrix; and at least one active agent. The device finds utility in the delivery of at least one active agent, and is useful in methods of reducing cell infiltration, inflammation and collagen deposition in a tissue or treating fibrosis in a tissue. In an aspect, the device can alleviate post-operative inflammation and/or fibrosis; and can also improve patient compliance for effective delivery of an active agent.

Abstract: The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.

Abstract: A method of producing an acellular peripheral nerve graft comprises the steps of providing a section of peripheral nerve, primary treatment of the section of peripheral nerve comprising freezing and then thawing the section of peripheral nerve, freeze-drying the thawed section of peripheral nerve longitudinally to introduce longitudinal pores into the section of peripheral nerve, and decellularization of the section of peripheral nerve comprising contacting the freeze-dried section of peripheral nerve with detergent and enzymatic decellularization agents to provide the acellular peripheral nerve graft. 9. The acellular peripheral nerve graft typically has an average pore size of at least 40 ?m and a DNA content of less than 100 ng/mg.

Abstract: A collagen scaffold for the delivery of bioactive agents such as antimicrobials comprising a first collagen matrix layer and a second collagen matrix layer in which the first collagen matrix layer comprises a first bioactive agent physically entrapped in the first collagen matrix layer and the second collagen matrix layer comprises a second bioactive agent chemically attached to the second collagen matrix layer for an initial high concentration elution of antimicrobial from the first collagen matrix layer followed by a sustained release from the second collagen matrix layer to prevent re-infection.

Abstract: A star polypeptide for use as a medicament, the star polypeptide comprising or consisting of a core and polypeptide arms radiating from the core. The star polypeptide may be used to deliver a therapeutic cargo and/or for its intrinsic properties. Therapeutic cargoes include a protein(e.g. VEGF); a nucleic acid (e.g. in vitro transcribed mRNA or microRNA); and/or a drug (e.g. diclofenac, azithromycin and/or rifampicin). Intrinsic properties include osteogenesis, angiogenesis and inhibition of bacteria.

Abstract: The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.

Abstract: The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.

Abstract: A nerve regeneration device comprising a bioresorbable conduit and a matrix contained therein having elongate pores aligned with the longitudinal axis of the conduit. The matrix comprises collagen, fibronectin, laminin-1, and laminin-2, wherein the amount, by weight, of laminin-1 or laminin-2 is greater than the amount of fibronectin in the matrix.

Abstract: The invention relates to a method for representing an environmental region of a motor vehicle in an image, in which real images of the environmental region are captured by a plurality of real cameras of the motor vehicle and the image is generated from these real images, which at least partially represents the environmental region, wherein the image is represented from a perspective of a virtual camera arranged in the environmental region, and the image is generated as a bowl shape, wherein at least one virtual elongated distance marker is represented in the image, by which a distance to the motor vehicle is symbolized in the virtual bowl shape. The invention also relates to a computer program product and a display system for a motor vehicle.

Abstract: An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):

Abstract: The invention relates to a method for assisting a driver of a motor vehicle (1) in maneuvering the motor vehicle (1) with a trailer (3), wherein image data is captured from an environmental region (12) of the motor vehicle (1) by means of at least one vehicle-side camera (5) and by means of at least one trailer-side camera (10) and an image (B) of the environmental region (12) is created for displaying on a vehicle-side display device (14) depending on the captured image data, wherein a perspective (P1, P2), from which the environmental region (12) is displayed in the image (B), is determined depending on a pivot angle (17) between the trailer (3) and the motor vehicle (1). The invention additionally relates to a driver assistance system (2) as well as to a vehicle/trailer combination with a motor vehicle (1), a trailer (3) and a driver assistance system (2).

Abstract: An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):

Abstract: An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):

Abstract: The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.

Abstract: The invention relates to a method for assisting a driver of a motor vehicle (1) in maneuvering the motor vehicle (1) with a trailer (3), wherein image data is captured from an environmental region (12) of the motor vehicle (1) by means of at least one vehicle-side camera (5) and by means of at least one trailer-side camera (10) and an image (B) of the environmental region (12) is created for displaying on a vehicle-side display device (14) depending on the captured image data, wherein a perspective (P1, P2), from which the environmental region (12) is displayed in the image (B), is determined depending on a pivot angle (17) between the trailer (3) and the motor vehicle (1). The invention additionally relates to a driver assistance system (2) as well as to a vehicle/trailer combination with a motor vehicle (1), a trailer (3) and a driver assistance system (2).

Abstract: An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):