Patents by Inventor Fernanda I. Staquicini

Fernanda I. Staquicini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-Drug Conjugates Against the Receptor Tyrosine Kinase EphA5
    Publication number: 20240115722
    Abstract: The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).
    Type: Application
    Filed: July 27, 2023
    Publication date: April 11, 2024
    Applicants: Rutgers, The State University of New Jersey, MBrace Therapeutics, Inc.
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini
  • CELL-FREE METHODS OF PRODUCING ANTIBODIES TO INTRACELLULAR TARGETS
    Publication number: 20240068004
    Abstract: Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modified cell-free systems for use in such methods in which the cell free protein expression system is modified by an agent which binds to the intracellular target protein or to the antibody paratope and thus prevents the antibody from binding to the target protein.
    Type: Application
    Filed: May 2, 2023
    Publication date: February 29, 2024
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Yongjian Wu, Fernanda I. Staquicini, Isan Chen
  • COMPOSITIONS TARGETING TUMOR ASSOCIATED MACROPHAGES AND METHODS USING SAME
    Publication number: 20240050580
    Abstract: In one aspect, the present disclosure relates to tumor associated macrophage (TAM) targeting peptide. In another aspect, the present disclosure relates to a method of targeting a TAM in a subject, the method comprising administering to the subject a TAM targeting peptide attached to and/or displayed on the surface of a solid particle. In yet another aspect, the present disclosure relates to a method of treating a tumor infiltrated with a TAM in a subject, the method comprising administering to the subject a TAM targeting peptide attached to and/or displayed on the surface of a solid particle.
    Type: Application
    Filed: December 20, 2021
    Publication date: February 15, 2024
    Applicants: Rutgers, The State University of New Jersey, Board of Regents, The University of Texas System
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini, Amin Hajitou, Wouter Driessen, Daniela Staquicini, Bettina Proneth
  • CELL-FREE METHODS OF RECOMBINANT ANTIBODY PRODUCTION
    Publication number: 20240010714
    Abstract: Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modified cell-free systems for use in such methods in which the modified system is engineered to express a variant target protein that has a mutant epitope of the target epitope of an antibody.
    Type: Application
    Filed: May 2, 2023
    Publication date: January 11, 2024
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Yongjian Wu, Fernanda I. Staquicini, Isan Chen
  • METHODS OF RECOMBINANT ANTIBODY PRODUCTION AND RELATED CELL SYSTEMS
    Publication number: 20230416798
    Abstract: Provided herein are methods and cell systems for production of a recombinant antibody in cells in which the antibody is directed against a target protein that is natively expressed as an intracellular protein in the cell. Also provided herein are modified cell lines for use in such methods in which the modified cell line is engineered to express a variant target protein that has a mutant epitope of the target epitope of an antibody.
    Type: Application
    Filed: May 2, 2023
    Publication date: December 28, 2023
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Fernanda I. Staquicini, Renata Pasqualini
  • ANTIBODY-DRUG CONJUGATES AGAINST THE RECEPTOR TYROSINE KINASE EPHA5
    Publication number: 20230293710
    Abstract: The present invention relates in certain aspects to antibodies, binding polypeptides, and immunoconjugates specific for human EPH receptor A5 (EphA5).
    Type: Application
    Filed: November 3, 2022
    Publication date: September 21, 2023
    Applicants: Rutgers, The State University of New Jersey, MBrace Therapeutics, Inc.
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini
  • COMPOSITIONS AND METHODS RELATED TO DNA DAMAGE REPAIR
    Publication number: 20140377288
    Abstract: The present invention provides compositions and methods for treating a cancer associated with elevated expression and/or activity of receptor tyrosine kinases (e.g., Eph receptors), such as EphA5. In some embodiments, the present invention provides compositions and methods for identifying elevated expression or activity of receptor tyrosine kinases (e.g., Eph receptors), such as EphA5.
    Type: Application
    Filed: September 14, 2012
    Publication date: December 25, 2014
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Fernanda I. Staquicini, Renata Pasqualini, Wadih Arap