Abstract: Described herein are methods, systems, and computer-readable storage media for automated detection of attention deficit hyperactivity disorder (ADHD). Techniques include providing stimuli to a user to activate a plurality of brain regions representing an attention network by displaying information with a first condition that causes a reaction and a second condition as an exception to the first condition. Techniques further include retrieving a plurality of signals from the plurality of brain regions for each of the stimuli, wherein each signal of the plurality of signals is accessed over a period of time that starts when the information is displayed and ends when the reactions of the user are captured. Further, the attention deficit detection system evaluates the signals to detect ADHD based on the level of connectivity within the attention network when each signal of the plurality of signals corresponds to the one or more stimuli.

Abstract: A method for tracking availability of a point-of-care (POC) device for a user is provided. The method comprises entering type(s) of test(s) needed by the user, providing a list of available POC devices to the user based on the type(s) of test(s) needed, based on the list of available POC devices, providing a map to the user showing locations of nearby POC devices with availability for the type(s) of test(s) needed; selecting one of the nearby POC devices by touching the location of the POC device on the map and booking that POC device for the type(s) of test(s) needed at a particular time slot, and communicating the booking to the selected POC device. The selected POC device then blocks that time slot.

Abstract: One embodiment of a plurality of dice with markings such that when the primary die is rolled a user either lands on a randomized result within the predetermined probability distribution or is directed to roll a secondary die which either provides a result or directs the user to roll a tertiary die. In the embodiments discussed here the final result is achieved on the first roll over 90% of the time. The embodiments described and shown are capable of representing complex distributions that include highly improbable outcomes, providing users with the convenient alternative of simply reading the result rather than performing comparative and mathematical operations on the results of multiple dice rolls.

Abstract: A rotary internal combustion engine, comprising at least one first and second piston, hub and side-disk assembly set each of the piston, hub and side-disk assembly sets having first and second pistons that are fixed on a side disk diametrically opposite each other, the hubs cooperating with each other so that the first and second pistons, hub and side disk of the first piston, hub and side-disk assembly can also rotate relative to the first and second pistons, hub and side disk of the second piston, hub and side-disc assembly, such that in operation one of said pistons will be a leading piston and one a trailing piston said disks being connected to the periphery of a set of two one way clutches or ratchets placed back-to-back, one being adapted to connect and disconnect with the shaft and therefore provide for fast moving/direct torque and the other being adapted to connect/disconnect with a planetary gear train's planets carrier and therefore provide a multiplied torque-to-force advancement of the trailing p

Abstract: Certain embodiments of 60-sided and 120-sided replacement dice each having a probability distribution equivalent to that of a subject die with fewer faces than the corresponding replacement die such that each replacement die can be used in place of the corresponding subject die.

Abstract: The present invention discloses an herbal composition comprising a therapeutic effective amount of Cascalote (Caesalpinia coriaria) and a therapeutic effective amount of Ruda (Ruta graveolens). In another implementation, the herbal composition can also comprise of an effective amount of at least one pharmaceutically acceptable excipient for application to the body, including skin and tissue. The disclosed invention also includes a method for making the herbal composition and a method of application of the herbal composition.

Abstract: Non ligand binding pocket antagonists for the human androgen receptor. The androgen receptor (AR) is a member of the Nuclear Receptor (NR) family and its role is to modulate the biological effects of the endogenous androgens, testosterone (tes) and dihydrotestosterone (DHT). Synthetic androgens and anti-androgens have therapeutic value in the treatment of various androgen dependent conditions, from regulation of male fertility to prostate cancer. Current treatment of prostate cancer (PCa) typically involves administration of ‘classical’ antiandrogens, competitive inhibitors of natural AR ligands, DHT and tes, for the ligand binding pocket (LBP) in the C-terminal ligand binding domain (LBD) of the AR. However, prolonged LBP-targeting can often lead to androgen resistance and alternative therapies and therapeutic strategies are urgently required. Disclosed herein are a class of non-steroidal, small molecule AR antagonists which inhibit the transcriptional activity of the AR by non LBP-mediated modulation.

Abstract: A rotary internal combustion engine, comprising at least one first and second piston, hub and side-disk assembly set each of the piston, hub and side-disk assembly sets having first and second pistons that are fixed on a side disk diametrically opposite each other, the hubs cooperating with each other so that the first and second pistons, hub and side disk of the first piston, hub and side-disk assembly can also rotate relative to the first and second pistons, hub and side disk of the second piston, hub and side-disc assembly, such that in operation one of said pistons will be a leading piston and one a trailing piston said disks being connected to the periphery of a set of two one way clutches or ratchets placed back-to-back, one being adapted to connect and disconnect with the shaft and therefore provide for fast moving/direct torque and the other being adapted to connect/disconnect with a planetary gear train's planets carrier and therefore provide a multiplied torque-to-force advancement of the trailing p

Abstract: Non ligand binding pocket antagonists for the human androgen receptor. The androgen receptor (AR) is a member of the Nuclear Receptor (NR) family and its role is to modulate the biological effects of the endogenous androgens, testosterone (tes) and dihydrotestosterone (DHT). Synthetic androgens and anti-androgens have therapeutic value in the treatment of various androgen dependent conditions, from regulation of male fertility to prostate cancer. Current treatment of prostate cancer (PCa) typically involves administration of ‘classical’ antiandrogens, competitive inhibitors of natural AR ligands, DHT and tes, for the ligand binding pocket (LBP) in the C-terminal ligand binding domain (LBD) of the AR. However, prolonged LBP-targeting can often lead to androgen resistance and alternative therapies and therapeutic strategies are urgently required. Disclosed herein are a class of non-steroidal, small molecule AR antagonists which inhibit the transcriptional activity of the AR by non LBP-mediated modulation.

Abstract: A rotary internal combustion engine has first and second paddles, hubs and side-discs substantially sealingly in the internal-combustion-cycle chamber and freely rotatable on a drive shaft, First and second gear trains are for rotation by the respective end portions of the hubs.

Abstract: A rotary internal combustion engine, has an engine block defining a drum-shaped combustion chamber. A rotatable propeller shaft extends axially through the chamber. First and second paddle and hub devices are freely rotating on the propeller shaft at least substantially sealingly in the chamber, each of the paddle and hub devices having first and second paddles that are fixed diametrically opposite each other with a hub therebetween. The hubs cooperate with each other so that the first paddle and hub device can also rotate relative to the second paddle and hub device, the hubs of the first and second paddle and hub means having end portions respectively extending from axially opposite ends of the chamber.