Abstract: An internal inclined sub-channel, or ramp device, for suspending and/or re-suspending solids within a pipeline system during transport of slurry may be provided to various components of the slurry transport system to control or reduce localized and severe wear that often occurs in slurry pumps. Embodiments of the ramp device may be adequately configured to alter slurry multiphase flow patterns and/or disrupt traditional moving/sliding bed regime phenomena. Embodiments of the ramp device may be adequately configured to raise coarse abrasive particulates from bottom portions of a slurry pipe section—where a higher concentration and/or a larger presence of coarser particles may be present. Embodiments of the ramp device may be installed in proximity of and/or upstream of slurry pumps to prevent occurrences of severe localized wear at the inner diameter of the pump suction side wall around the bottom or 6 o'clock position.

Abstract: The invention relates to an extract from coffee pulp, a process for its preparation and its use in agrochemical against plant pathogens, especially against fungal infections. The invention also relates to the use of the main active ingredient contained in the extract in agrochemical, optionally in combination with other fungicide agents and/or agents that act as defence elicitors.

Abstract: An internal inclined sub-channel, or ramp device, for suspending and/or re-suspending solids within a pipeline system during transport of slurry may be provided to various components of the slurry transport system to control or reduce localized and severe wear that often occurs in slurry pumps. Embodiments of the ramp device may be adequately configured to alter slurry multiphase flow patterns and/or disrupt traditional moving/sliding bed regime phenomena. Embodiments of the ramp device may be adequately configured to raise coarse abrasive particulates from bottom portions of a slurry pipe section—where a higher concentration and/or a larger presence of coarser particles may be present. Embodiments of the ramp device may be installed in proximity of and/or upstream of slurry pumps to prevent occurrences of severe localized wear at the inner diameter of the pump suction side wall around the bottom or 6 o'clock position.

Abstract: A suction pipe inlet device for a centrifugal pump, the device having a hollow tubular axisymmetric body along a longitudinal axis having an open first end adapted for fitting into or against a retention tank; an open second end adapted for fitting into or against an inflow end of a suction pipe having an outer pipe diameter and an inner pipe diameter; a converging section located closer to the retention tank; a diverging section located closer to the suction pipe; a throat located at the intersection point between the converging and diverging sections, the converging and diverging sections defining an interior converging-diverging geometry within the tubular axisymmetric body and the throat defining a minimum inner cross sectional area of the tubular axisymmetric body.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.

Abstract: Provided are non-limiting embodiments of a wear-resistant impeller having a non-conventional blending provided between a surface of a vane (1) and a surface of at least one of a front side shroud (15) and a rear side shroud (16). The impeller may comprise both a rear side blending (3) and a front side blending (2), and the front side blending (2) may comprise a different geometry from the rear side blending (3). The blending preferably comprises a bulbous geometry which is uniquely adapted for optimizing flow patterns adjacent to the vane and between the front and rear side shrouds in a manner which discourages the formation of horseshoe vortices proximate the leading edge (6) of the vane (1) during operation. Through the reduction, mitigation, or elimination of horseshoe vortices, local high velocities and turbulence are generally minimized, and wear experienced by portions of the impeller (e.g., to one or more vanes) from flows of abrasive slurry can be reduced.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.

Abstract: A suction pipe inlet device for a centrifugal pump, the device having a hollow tubular axisymmetric body along a longitudinal axis having an open first end adapted for fitting into or against a retention tank; an open second end adapted for fitting into or against an inflow end of a suction pipe having an outer pipe diameter and an inner pipe diameter; a converging section located closer to the retention tank; a diverging section located closer to the suction pipe; a throat located at the intersection point between the converging and diverging sections, the converging and diverging sections defining an interior converging-diverging geometry within the tubular axisymmetric body and the throat defining a minimum inner cross sectional area of the tubular axisymmetric body.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.

Abstract: This invention relates to electrophysiological assays that measure sodium conductance activity of a delta human epithelial sodium channel (ENaC) in the presence and absence of delta hENaC enhancers. Also, the invention generally relates to assays for identifying compounds that enhance the activity of delta hENaC, especially in an oocyte expression system. These compounds have potential application in modulating (enhancing) salty taste perception.

Abstract: Provided are non-limiting embodiments of a wear-resistant impeller having a non-conventional blending provided between a surface of a vane and a surface of at least one of a front side shroud (15) and a rear side shroud (16). The impeller may comprise both a rear side blending gland a front side blending (2), and the front side blending (2) may comprise a different geometry from the rear side blending (3). The blending preferably comprises a bulbous geometry which is uniquely adapted for optimizing flow patterns adjacent to the vane and between the front and rear side shrouds in a manner which discourages the formation of horseshoe vortices proximate the leading edge (6) of the vane (1) during operation. Through the reduction, mitigation, or elimination of horseshoe vortices, local high velocities and turbulence are generally minimized, and wear experienced by portions of the impeller (e.g., to one or more vanes) from flows of abrasive slurry can be reduced.

Abstract: The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material. The purified polymer or dimer can be used as a colorant by itself or in combination with another colorant for imparting color to a food, a drug, a cosmetic, a medical device, and textile products.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.

Abstract: This invention relates to electrophysiological assays that measure sodium conductance activity of a delta human epithelial sodium channel (ENaC) in the presence and absence of delta hENaC enhancers. Also, the invention generally relates to assays for identifying compounds that enhance the activity of delta hENaC, especially in an oocyte expression system. These compounds have potential application in modulating (enhancing) salty taste perception.

Abstract: The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material. The purified polymer or dimer can be used as a colorant by itself or in combination with another colorant for imparting color to a food, a drug, a cosmetic, a medical device, and textile products.

Abstract: The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material. The purified polymer or dimer can be used as a colorant by itself or in combination with another colorant for imparting color to a food, a drug, a cosmetic, a medical device, and textile products.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1 R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.