Patents by Inventor Fernando Espliego

Fernando Espliego has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolocarbazole alkaloids from a marine actinomycete
    Patent number: 6852715
    Abstract: The invention provides compounds of formula (1) wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and R2 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: February 8, 2005
    Assignee: Instituto Biomar S.A.
    Inventors: Dolores Garcia Gravalos, Julia Perez, Librada Maria Cañedo, Francisco Romero, Fernando Espliego
  • Polycylic xanthones and their use
    Patent number: 6812245
    Abstract: A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: November 2, 2004
    Assignee: Instituto Biomar S.A.
    Inventors: Librada Maria Cañedo, Dolores Garcia Gravalos, Francisco Romero, Fernando Espliego, Julia Perez-Baz
  • Polycylic xanthones and their use
    Publication number: 20040009928
    Abstract: A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.
    Type: Application
    Filed: June 9, 2003
    Publication date: January 15, 2004
    Inventors: Librada Maria Caedo, Dolores Garcia Gravalos, Francisco Romero, Fernando Espliego, Julia Perez-Baz
  • Use of citreamicins
    Publication number: 20030236291
    Abstract: Citreamicins possess useful antitumor activity. Typically they are of formula, wherein R1 is selected from the group consisting of COCH2CH(CH3)2, COCH3 or H when R2 is CH3, or wherein R1 is COCH2CH(CH3)2, and R2 is H.
    Type: Application
    Filed: July 25, 2003
    Publication date: December 25, 2003
    Inventors: Dolores Garcia Gravalos, Jose Luis Fernandez Puentes, Librada Maria Canedo Fernandez, Julia Perez-Baz, Francisco Romero-Millan, Fernando Espliego-Vazquez
  • Macrolides with antitumor activity
    Patent number: 6395711
    Abstract: The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: May 28, 2002
    Assignee: Instituto Biomar S.A.
    Inventors: Rosa Isabel Fernandez-Chimeno, Francisco Romero, Jose Luis Fernandez-Puentes, Julia Perez-Baz, Librada Maria Canedo, Fernando Espliego