Patents by Inventor Fernando Guillermo Abarzua Cabezas

Fernando Guillermo Abarzua Cabezas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Direct administration of REIC/Dkk-3 to mesothelioma
    Patent number: 9475865
    Abstract: This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: October 25, 2016
    Inventors: Hiromi Kumon, Nam-ho Huh, Masakiyo Sakaguchi, Yasutomo Nasu, Fernando Guillermo Abarzua Cabezas
  • Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same
    Patent number: 8618273
    Abstract: This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: December 31, 2013
    Inventors: Hiromi Kumon, Nam-ho Huh, Masakiyo Sakaguchi, Yasutomo Nasu, Fernando Guillermo Abarzua Cabezas
  • Partial Fragment of REIC/Dkk-3 Gene and Cancer Therapeutic Agent Comprising the Same
    Publication number: 20130274199
    Abstract: This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.
    Type: Application
    Filed: June 24, 2013
    Publication date: October 17, 2013
    Inventors: HIROMI KUMON, NAM-HO HUH, MASAKIYO SAKAGUCHI, YASUTOMO NASU, FERNANDO GUILLERMO ABARZUA CABEZAS
  • Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same
    Publication number: 20100173404
    Abstract: This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.
    Type: Application
    Filed: October 24, 2007
    Publication date: July 8, 2010
    Inventors: Hiromi Kumon, Nam-ho Huh, Masakiyo Sakaguchi, Yasutomo Nasu, Fernando Guillermo Abarzua Cabezas