Patents by Inventor Fernando Kok

Fernando Kok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for methylmalonic acid detemination based on alkylative extraction associated to liquid chromatography coupled to mass spectrometry
    Patent number: 8067242
    Abstract: The present invention relates to the determination of the presence of methylmalonic acid in biologic samples including the steps of methylmalonic extraction from the sample; derivatization of methylmalonic acid and use of mass spectrometry with negative mode atmospheric pressure chemical ionization to determine the presence of methymalonic acid throughthe formation of an ion of mass to charge ratio (m/z) 477. An additional objective of the present invention concerns diagnosis kits for determination of presence and quantification of methylmalonic acid based on the method mentioned before.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: November 29, 2011
    Inventors: Valdemir Melechco Carvalho, Fernando Kok
  • Method for methylmalonic acid detemination based on alkylative extraction associated to liquid chromatography coupled to mass spectrometry
    Publication number: 20100304492
    Abstract: The present invention relates to the determination of the presence of methylmalonic acid in biologic samples including the steps of methylmalonic extraction from the sample; derivatization of methylmalonic acid and use of mass spectrometry with negative mode atmospheric pressure chemical ionization to determine the presence of methymalonic acid through the formation of an ion of mass to charge ratio (m/z) 477. An additional objective of the present invention concerns diagnosis kits for determination of presence and quantification of methylmalonic acid based on the method mentioned before.
    Type: Application
    Filed: November 5, 2007
    Publication date: December 2, 2010
    Applicants: INSTITUTO FLEURY, FLEURY S/A
    Inventors: Valdemir Melechco Carvalho, Fernando Kok