Patents by Inventor Fernando Leal Calderon

Fernando Leal Calderon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220015382
    Abstract: The present invention relates to a multiple emulsion comprising or consisting of P1/O/W2, wherein P1 is an aqueous phase forming droplets or a gas phase forming bubbles, said droplets or bubbles being dispersed in O thereby forming P1/O, wherein O is an oily phase comprising crystals, wherein W2 is an aqueous phase comprising at least one hydrophilic surfactant, wherein P1/O globules are formed in W2, wherein said oily phase O comprises at least 90%, preferably at least 92%, and even preferably at least 95%, by mass of triglycerides with respect to the mass of the O phase. The present invention relates to a process for preparing such multiple emulsion and applications thereof. Food, cosmetic and pharmaceutical compositions as well as a packaging containing a composition are claimed.
    Type: Application
    Filed: November 14, 2019
    Publication date: January 20, 2022
    Inventors: Lucie Goibier, Chrystel Faure, Fernando Leal Calderon, Cyril Chaudemanche
  • Patent number: 11103808
    Abstract: The present invention is a process for recovering an isoprenoid compound produced by fermentation from a fermentation medium comprising: (a) demulsifying the fermentation medium or a fraction thereof in presence of a salt and a surfactant, thereby generating a stream having an organic phase containing the isoprenoid compound and a phase heavier than the organic phase, and (b) separating the stream obtained in step (a) into the organic phase containing the isoprenoid compound, the phase heavier than the organic phase, and optionally a solid phase containing host cell debris and cells.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: August 31, 2021
    Assignee: Amyris, Inc.
    Inventors: Maha Bahi, Anthony Hutin, Fernando Leal-Calderon
  • Publication number: 20200179824
    Abstract: The present invention is a process for recovering an isoprenoid compound produced by fermentation from a fermentation medium comprising: (a) demulsifying the fermentation medium or a fraction thereof in presence of a salt and a surfactant, thereby generating a stream having an organic phase containing the isoprenoid compound and a phase heavier than the organic phase, and (b) separating the stream obtained in step (a) into the organic phase containing the isoprenoid compound, the phase heavier than the organic phase, and optionally a solid phase containing host cell debris and cells.
    Type: Application
    Filed: August 1, 2018
    Publication date: June 11, 2020
    Inventors: Maha Bahi, Anthony Hutin, Fernando Leal-Calderon
  • Patent number: 9770520
    Abstract: The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising: an aqueous phase, representing 70% to 90% by weight of the composition, advantageously 75% to 85% and more advantageously from 78% to 82% a lipid phase comprising an oil, representing 9.5% to 29.5% by weight of the composition, advantageously 14% to 25% and more advantageously 17% to 21%, a surfactant at the interface between the aqueous and lipid phases, the surfactant comprising at least one amphiphilic paramagnetic metal chelate and optionally an amphiphilic lipid; the total content of surfactant by weight relative to the oil being between 4% and 10% and advantageously between 5% and 8%; the total content of surfactant by weight relative to the composition being between 0.35% and 2.95% and advantageously between 0.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: September 26, 2017
    Assignees: GUERBET, UNIVERSITE DE BORDEAUX
    Inventors: Marc Port, Caroline Robic, Fernando Leal Calderon, Samy Chadel
  • Publication number: 20130309176
    Abstract: The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising: an aqueous phase, representing 70% to 90% by weight of the composition, advantageously 75% to 85% and more advantageously from 78% to 82% a lipid phase comprising an oil, representing 9.5% to 29.5% by weight of the composition, advantageously 14% to 25% and more advantageously 17% to 21%, a surfactant at the interface between the aqueous and lipid phases, the surfactant comprising at least one amphiphilic paramagnetic metal chelate and optionally an amphiphilic lipid; the total content of surfactant by weight relative to the oil being between 4% and 10% and advantageously between 5% and 8%; the total content of surfactant by weight relative to the composition being between 0.35% and 2.95% and advantageously between 0.
    Type: Application
    Filed: December 20, 2011
    Publication date: November 21, 2013
    Applicants: UNIVERSITE DE BORDEAUX 1, GUERBET
    Inventors: Marc Port, Caroline Robic, Fernando Leal Calderon, Samy Chadel
  • Publication number: 20090298723
    Abstract: The invention relates to a method for treating a reservoir rock, wherein the following stages are carried out: making a concentrated water-in-oil emulsion comprising: between 50% and 80% aqueous phase in which at least one treatment additive is dissolved and between 20% and 50% oil phase containing at least one polymeric surfactant, shearing the concentrated emulsion so as to obtain an emulsion having drops of substantially monodispersed size and essentially below 1 ?m, diluting the monodispersed emulsion with an oil phase so as to obtain an aqueous phase dispersed at a rate below 50%, and injecting the diluted emulsion into the reservoir rock.
    Type: Application
    Filed: February 13, 2007
    Publication date: December 3, 2009
    Inventors: Fernando Leal Calderon, Bazin Brigitte, Romero Carolina
  • Patent number: 7214717
    Abstract: A fractionable polydisperse stable double oil-in-water emulsion, having 50 to 95 wt. % relative to the total weight of the double emulsion, droplets of an invert monodisperse emulsion Ei dispersed in a continuous aqueous phase. The continuous aqueous phase includes a polysaccharide thickening agent in a proportion of 1 to 10 wt. % relative to the total weight of the continuous aqueous phase, a water-soluble ethylene oxide and propylene oxide block copolymer as surfactant, and an osmotic pressure balancing agent. The emulsion Ei has a viscosity not higher than the viscosity of the continuous aqueous phase and has 50 to 95 wt. %, relative to the total weight of Ei, droplets of an internal aqueous phase dispersed in an oily phase. The internal aqueous phase includes an active hydrophilic substance and the oily phase includes poly glycerol polyricinoleate as surfactant.
    Type: Grant
    Filed: September 4, 2000
    Date of Patent: May 8, 2007
    Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Jérôme Michel Jaques Bibette, Fernando Leal Calderon, Philippe Gorria
  • Publication number: 20040116541
    Abstract: A method for preparing a monodispersed double water/oil/water emulsion, comprises: a) subjecting a polydispered oil-in-water emulsion Ei comprising 55 to 99 wt. % of an aqueous phase, to a controlled shearing to obtain the corresponding monodispersed invert emulsion; b) adding to the emulsion, without phase inversion, the necessary amount of diluting oil phase so that the aqueous phase of the resulting emulsion represents at least 50 wt. % of the emulsion total weight; and c) introducing the resulting emulsion into a high pressure homogenizer, together with a continuous aqueous phase, the respective amounts of the emulsion and the continuous aqueous phase being such that the resulting double emulsion comprises up to 50 wt. % of invert emulsion droplets relative to the emulsion total weight, the continuous aqueous phase comprising a hydrophilic surfactant concentration not more that 0.02 times the critical micellar concentration.
    Type: Application
    Filed: August 13, 2003
    Publication date: June 17, 2004
    Inventors: Fernando Leal Calderon, Jerome Michel Jacques Bibette
  • Patent number: 6627603
    Abstract: A method for the controlled release of an active principle contained in a multiple water-in-oil-in-water emulsion characterized in that the multiple emulsion comprises an invert emulsion Ei with an aqueous phase A1 containing at least a hydrophilic active principle. The emulsion Ei is dispersed in the form of direct emulsion droplets Ed, in a continuous aqueous phase A2, with the two emulsions Ed and Ei stabilized by at least a surfactant, present in their respective continuous phases. The multiple emulsion is brought in the presence of an effective amount of an agent for transforming it into a direct emulsion and induce the release of the active principle, contained in the aqueous phase A1 of emulsion Ei, in the aqueous phase A2.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: September 30, 2003
    Assignee: Centre National de la Recherche Scientifiquue (C.N.R.S.)
    Inventors: Jérôme Bibette, Marie-Françoise Ficheux, Fernando Leal Calderon, Lida Bonnakdar
  • Patent number: 6602917
    Abstract: A process provides a stable emulsion, in particularly a stable, concentrated bitumen emulsion, by emulsifying a first hydrophobic or hydrophilic phase having a viscosity between 1 and 5000 Pa.s with a second phase immiscible in the first phase, in the presence of at least one surfactant, by mixing together the first phase, second phase, and surfactant under a laminar shear regime.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: August 5, 2003
    Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Fernando Leal Calderon, Jerôme Bibette, Florence Guimberteau