Patents by Inventor Fernando Pedro Cossio
Fernando Pedro Cossio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230390308Abstract: Compounds derived from ursodeoxycholic acid of formula (I) and to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.Type: ApplicationFiled: July 17, 2023Publication date: December 7, 2023Inventors: Jesus Maria BANALES ASURMENDI, Luis BUJANDA FERNANDEZ DE PIEROLA, Alvaro SANTOS LASO, Fernando Pedro COSSIO MORA, Ivan RIVILLA DE LA CRUZ, Francisco Javier CABALLERO CAMINO, Manel ESTELLER BADOSA, Jose Juan GARCIA MARIN
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Patent number: 11833160Abstract: The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.Type: GrantFiled: December 28, 2018Date of Patent: December 5, 2023Assignees: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA, ADMINISTRACIO GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI, FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL), UNIVERSIDAD DE SALAMANCAInventors: Jesus Maria Banales Asurmendi, Luis Bujanda Fernandez De Pierola, Alvaro Santos Laso, Fernando Pedro Cossio Mora, Ivan Rivilla De La Cruz, Francisco Javier Caballero Camino, Manel Esteller Badosa, Jose Juan Garcia Marin
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Publication number: 20210137946Abstract: The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.Type: ApplicationFiled: December 28, 2018Publication date: May 13, 2021Inventors: Jesus Maria BANALES ASURMENDI, Luis BUJANDA FERNANDEZ DE PIEROLA, Alvaro SANTOS LASO, Fernando Pedro COSSIO MORA, Ivan RIVILLA DE LA CRUZ, Francisco Javier CABALLERO CAMINO, Manel ESTELLER BADOSA, Jose Juan GARCIA MARIN
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Publication number: 20160122340Abstract: The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, neurological disorders and immunological disorders.Type: ApplicationFiled: May 9, 2014Publication date: May 5, 2016Inventors: Fernando Pedro COSSÍO MORA, Yosu Ion VARA SALAZAR, María del Carmen MASDEU MARGALEF, María Remedios ALCALÁ CAFFARENA, Sergio VILLAFRUELA CÁNEVA, Dorleta OTAEGUI ANSA, Eneko ALDABA ARÉVALO, Aizpea ZUBIA OLASCOAGA, Eider SAN SEBASTIÁN LARZABAL
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Publication number: 20150336889Abstract: The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.Type: ApplicationFiled: November 7, 2013Publication date: November 26, 2015Inventors: Fernando Pedro COSSÍO MORA, Yosu Ion VARA SALAZAR, María del Carmen MASDEU MARGALEF, María Remedios ALCALÁ CAFFARENA, Sergio VILLAFRUELA CÁNEVA, Dorleta OTAEGUI ANSA, Eneko ALDABA ARÉVALO, Eider SAN SEBASTIÁN LARZABAL, Aizpea ZUBIA OLASCOAGA
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Publication number: 20150038545Abstract: The present invention refers to compounds derived from hydroxyphenyl 1H-pyrrole rings, which have the following formula (I): as well as to the procedure for their preparation, pharmaceutical compositions comprising the same and the use thereof for the treatment and/or prevention of a condition mediated by histone deacetylase such as cancer, hematological malignancies, autoimmune diseases, inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases and psychiatric disorders, cardiovascular diseases, endocrine and metabolic disorders, by inhibiting histone deacetylases and the therapeutic use of biological processes related to the mentioned inhibition.Type: ApplicationFiled: April 4, 2012Publication date: February 5, 2015Applicants: UNIVERSIDAD DEL PAÍS VASCO, IKERCHEM, S.L.Inventors: Fernando Pedro Cossío Mora, Yosu Ion Vara Salazar, Eider San Sebastián Larzabal, Dorleta Otaegui Ansa, María del Carmen Masdeu Margalef, Eneko Aldaba Arévalo, Maialen Aginagalde Unanue, Sergio Villafruela Cáneva, María Remedios Alcalá Caffarena, Aizpea ZUubia Olascoaga
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Patent number: 8835659Abstract: The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.Type: GrantFiled: May 10, 2011Date of Patent: September 16, 2014Assignees: Ikerchem, S.L., Universidad del Pais VascoInventors: Fernando Pedro Cossio Mora, Leire Lidia Arias Echeverría, Yosu Ion Vara Zalazar, Eneko Aldaba Arévalo, Eider San Sebastián Larzabal, Aizpea Zubia Olascoaga
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Patent number: 8685992Abstract: The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein: R1 and R2 represent, independently, an optionally substituted C6-C10 aryl radical or an optionally substituted heteroaryl radical; A and M represent, independently, a methylene group or a single bond, in which case the adjacent aromatic ring would be attached directly to the amide group; the Y?Z group represents together and indistinctly an oxygen atom, a sulfur atom, a cis-vinylidene group, an imino group, or a methine group with a sp2-hybridized carbon atom; X represents indistinctly a methine group, a cis-vinylidene group or a nitrogen atom; and W represents a hydroxyl group, an optionally substituted C1-C6 alkyl group, an optionally substituted heteroaryl group or an optionally substituted C6-C10 aryl group; or a salt, solvate or prodrug thereof, as well as to the process for their preparation and the use thereof for the treatment of cancer.Type: GrantFiled: October 1, 2010Date of Patent: April 1, 2014Assignees: Universidad del País Vasco, Ikerschem, S.L.Inventors: Fernando Pedro Cossío Mora, Aizpea Zubia Olascoaga, Yosu Vara Salazar, Eider Ion San Sebastián Larzabal, Dorleta Otaegui Ansa, María del Carmen Masdeu Margalef, Eneko Aldaba Arévalo
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Publication number: 20130217730Abstract: The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.Type: ApplicationFiled: May 10, 2011Publication date: August 22, 2013Applicant: IKERCHEM, S.L.Inventors: Fernando Pedro Cossio Mora, Leire Lidia Arias Echeverría, Yosu Ion Vara Zalazar, Eneko Aldaba Arévalo, Eider San Sebastián Larzabal, Aizpea Zubia Olascoaga
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Publication number: 20120196885Abstract: The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein: R1 and R2 represent, independently, an optionally substituted C6-C10 aryl radical or an optionally substituted heteroaryl radical; A and M represent, independently, a methylene group or a single bond, in which case the adjacent aromatic ring would be attached directly to the amide group; the Y?Z group represents together and indistinctly an oxygen atom, a sulfur atom, a cis-vinylidene group, an imino group, or a methine group with a sp2-hybridized carbon atom; X represents indistinctly a methine group, a cis-vinylidene group or a nitrogen atom; and W represents a hydroxyl group, an optionally substituted C1-C6 alkyl group, an optionally substituted heteroaryl group or an optionally substituted C6-C10 aryl group; or a salt, solvate or prodrug thereof, as well as to the process for their preparation and the use thereof for the treatment of cancer.Type: ApplicationFiled: October 1, 2010Publication date: August 2, 2012Applicant: IKERCHEM, S.L.Inventors: Fernando Pedro Cossío Mora, Aizpea Zubia Olascoaga, Yosu Vara Salazar, Eider Ion San Sebastián Larzabal, Dorleta Otaegui Ansa, María del Carmen Masdeu Margalef, Eneko Aldaba Arévalo
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Patent number: 8097656Abstract: This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.Type: GrantFiled: August 23, 2010Date of Patent: January 17, 2012Assignees: Dominion Pharmakine S.L, Universidad del Pais VascoInventors: Fernando Pedro Cossio, Eneko Aldaba Arevalo, Yosu Ion Vara Salazar, Aizpea Zubia Olascoaga, Silvia Vivanco Amato, Miren Lorea Mendoza Arteche, Clarisa Salado Pogonza, Natalia Gallot Escobal, Fernando Vidal Vanaclocha
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Patent number: 7943660Abstract: The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.Type: GrantFiled: November 14, 2005Date of Patent: May 17, 2011Assignee: Dominion Pharmakine S.L.Inventors: Natalia Gallot Escobal, Fernando Vidal Vanaclocha, Fernando Pedro Cossio Mora, Miren Lorea Mendoza Arteche, Aizpea Zubia Olascoaga, Maria Valcarcel Cuesta, Yosu Ion Vara Salazar, Miren Sorne Solaun Aguirre, Jose Javier Lopez Pestana, Eider San Sebastian Larzabal
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Publication number: 20110060038Abstract: This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.Type: ApplicationFiled: August 23, 2010Publication date: March 10, 2011Applicants: DOMINION PHARMAKINE S.L., UNIVERSIDAD DEL PAIS VASCOInventors: Fernando Pedro Cossio, Eneko Aldaba Arevalo, Yosu Ion Vara Salazar, Aizpea Zubia Olascoaga, Silvia Vivanco Amato, Miren Lorea Mendoza Arteche, Clarisa Salado Pogonza, Natalia Gallot Escobal, Fernando Vidal Vanaclocha
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Patent number: 7638550Abstract: The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases.Type: GrantFiled: December 27, 2005Date of Patent: December 29, 2009Assignee: Universidad del Pais Vasco-Euskal Herriko Unibertsitatea (UPV-EHU) Fundacion Centro Nacional de Investigaciones Oncologicas Carlos III (CNIO)Inventors: Fernando Pedro Cossio Mora, Manel Esteller Badosa, Aizpea Zubia Olascoaga, Dorleta Otaegui Ansa
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Publication number: 20090298905Abstract: This invention is related to new nitrogenated trans-stilbene analog compounds, more specifically, imine, pyrrol and Indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.Type: ApplicationFiled: April 12, 2006Publication date: December 3, 2009Inventors: Fernando Pedro Cossio, Eneko Aldaba Arevalo, Yosu Ion Vara Salazar, Aizpea Zubia Olascoaga, Silvia Vivanco Amato, Miren Lorea Mendoza Arteche, Clarisa Salado Pogonza, Natalia Gallot Escobal, Fernando Vidal Vanaclocha
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Patent number: 7446125Abstract: This invention relates to nitroproline derivative compounds and procedures for their preparation and the preparation of pharmaceutical compositions containing the compounds. The invention also relates to the administration of compounds of the invention as agents for the treatment of mammalian diseases whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable cellular and molecular activities or responses induced by integrin-dependent molecular interactions.Type: GrantFiled: April 14, 2006Date of Patent: November 4, 2008Assignees: Universidad del Pais Vasco, Dominion Pharmakine S.L.Inventors: Fernando Pedro Cossio, Eneko Aldaba Arévalo, Yosu Ion Vara Salazr, Aizpea Zubia Olascoaga, Silvia Vivanco Amato, Miren Lorea Mendoza Arteche, María Valcárcel Cuesta, Fernando Vidal Vanaclocha
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Publication number: 20080262073Abstract: The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases.Type: ApplicationFiled: December 27, 2005Publication date: October 23, 2008Inventors: Fernando Pedro Cossio Mora, Manel Esteller Badosa, Aizpea Zubia Olascoaga, Dorleta Otaegui Ansa
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Publication number: 20080249157Abstract: The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.Type: ApplicationFiled: November 14, 2005Publication date: October 9, 2008Applicants: DOMINION PHARMAKINE S.L., UNIVERSIDAD DEL PAIS VASCOInventors: Fernando Pedro Cossio Mora, Eider San Sebastian Larzabal, Miren Lorea Mendoza Arteche, Aizpea Zubia Olascoaga, Maria Valcarcel Cuesta, Yosu Ion Vara Salazar, Miren Sorne Solaun Aguirre, Jose Javier Lopez Pestana, Natalia Gallot Escobal, Fernando Vidal Vanaclocha