Abstract: A robotic pill system for collecting a sample from human and animal body cavities and liquid resources using a robotic pill. The system includes a robotic pill adapted to collect the sample when the robotic pill is received or introduced or taken through an orifice, other natural or surgical openings and cavity. A screw is present in the housing of the robotic pill and is adapted to collect the sample(s) from an opening in the housing into one or more collection chambers in the housing of the robotic pill. The robotic pill may be positionally located before operation of a sample as well as its position directed and may utilize a wireless interface to transmit positional information and/or control information for the screw.

Abstract: Airborne transmission of exhaled virus can rapidly spread by increasing disease progression from local incidents to pandemics. Due to the COVID-19 pandemic, states and local governments have enforced the use of protective masks in common and work areas to minimize disease spread. Here, the function of protective face coverings is leveraged towards COVID-19 diagnosis. A user-friendly, affordable, and wearable adhesive collector was developed. This non-invasive platform is integrated into protective masks towards collecting airborne virus exhaled from individuals' breath over the wearing period. After sampling or collecting, the enriched pathogen can be extracted from the collector for further analytical evaluation. To validate this design, qualitative colorimetric loop-mediated isothermal amplification (LAMP), quantitative reverse transcription polymerase chain reaction (RT-PCR), and antibody-based dot blot assays were performed to detect the presence of SARS-CoV-2.

Abstract: Disclosed are devices, systems and methods for in situ payload delivery via a degradable microneedle. In some aspects, a microneedle therapeutic payload delivery device includes a substrate; an activation particle; and one or more degradable microneedle structures coupled to the substrate and including a polymeric matrix structured to embed the activation microparticle and one or more therapeutic payloads, the one or more degradable microneedle structures each including an exterior wall spanning outward from a base surface and forming an apex at a terminus point of the exterior wall, wherein the polymeric matrix of a microneedle structure of the one or more degradable microneedle structures is degradable under an environmental parameter of a biofluid surrounding the microneedle structure to dissolve and allow the one or more therapeutic payloads and the activation particle to the surrounding biofluid.

Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.