Patents by Inventor Fernando Valle

Fernando Valle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLUCONATE DEHYDRATASE ENZYMES AND RECOMBINANT CELLS
    Publication number: 20230272364
    Abstract: Abstract: Gluconate dehydratase enzymes and recombinant cells are provided, along with their use in the production of 2-ke-to-3-deoxy-D-gluconate (KDG).
    Type: Application
    Filed: July 13, 2020
    Publication date: August 31, 2023
    Applicant: BP Corporation North America Inc.
    Inventor: Fernando Valle
  • Production of 2-keto-3-deoxy-d-gluconic acid in filamentous fungi
    Patent number: 11708571
    Abstract: A recombinant filamentous fungi that includes reduced 2-Keto-3-Deoxy-Gluconate (KDG) aldolase enzyme activity as compared to the filamentous fungi not transformed to have reduced KDG aldolase enzyme activity is provided. Also provided is a method of producing KDG.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: July 25, 2023
    Assignee: BP Corporation North America Inc.
    Inventors: Molly Krebs, Chris Phillips, Fernando Valle
  • Production of fatty acid esters
    Patent number: 11434512
    Abstract: Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: September 6, 2022
    Assignee: Genomatica, Inc.
    Inventors: Fernando Sanchez-Riera, Stephen Del Cardayre, Fernando Valle
  • ENHANCED PRODUCTION OF FATTY ACID DERIVATIVES
    Publication number: 20210355071
    Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.
    Type: Application
    Filed: May 5, 2021
    Publication date: November 18, 2021
    Inventors: Zhihao HU, Fernando VALLE
  • PRODUCTION OF 2-KETO-3-DEOXY-D-GLUCONIC ACID IN FILAMENTOUS FUNGI
    Publication number: 20210214706
    Abstract: A recombinant filamentous fungi that includes reduced 2-Keto-3-Deoxy-Gluconate (KDG) aldolase enzyme activity as compared to the filamentous fungi not transformed to have reduced KDG aldolase enzyme activity is provided.
    Type: Application
    Filed: May 14, 2019
    Publication date: July 15, 2021
    Inventors: Molly KREBS, Chris PHILLIPS, Fernando VALLE
  • Recombinant for enhanced production of fatty acid derivatives
    Patent number: 11046635
    Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: June 29, 2021
    Assignee: GENOMATICA, INC.
    Inventors: Zhihao Hu, Fernando Valle
  • Compositions and methods for producing isoprene
    Patent number: 10626420
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: April 21, 2020
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Marguerite A. Cervin, Gopal K. Chotani, Frank J. Feher, Richard La Duca, Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Aaron S. Puhala, Karl J. Sanford, Fernando Valle, Gregory M. Whited
  • PRODUCTION OF FATTY ACID ESTERS
    Publication number: 20200017890
    Abstract: Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described.
    Type: Application
    Filed: December 27, 2018
    Publication date: January 16, 2020
    Inventors: Fernando Sanchez-Riera, Stephen Del Cardayre, Fernando Valle
  • Enhanced Production Of Fatty Acid Derivatives
    Publication number: 20190031594
    Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.
    Type: Application
    Filed: April 16, 2018
    Publication date: January 31, 2019
    Applicant: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • COMPOSITIONS AND METHODS FOR PRODUCING ISOPRENE
    Publication number: 20180273982
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: January 17, 2018
    Publication date: September 27, 2018
    Applicants: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Marguerite A. CERVIN, Gopal K. CHOTANI, Frank J. FEHER, Richard LA DUCA, Joseph C. MCAULIFFE, Andrei MIASNIKOV, Caroline M. PERES, Aaron S. PUHALA, Karl J. SANFORD, Fernando VALLE, Gregory M. WHITED
  • Enhanced production of fatty acid derivatives
    Patent number: 10017455
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: July 10, 2018
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Compositions and methods for producing isoprene
    Patent number: 9909144
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: March 6, 2018
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Marguerite A. Cervin, Gopal K. Chotani, Frank J. Feher, Richard La Duca, Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Aaron S. Puhala, Karl J. Sanford, Fernando Valle, Gregory M. Whited
  • Enhanced Production of Fatty Acid Derivatives
    Publication number: 20170327799
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
    Type: Application
    Filed: June 9, 2017
    Publication date: November 16, 2017
    Applicant: REG Life Sciences LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Production of fatty alcohols from engineered microorganisms
    Patent number: 9714437
    Abstract: The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase (“FAR”); a gene encoding a heterologous thioesterase (“TE”) gene and a gene encoding an acyl-CoA synthetase (“ACS”).
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: July 25, 2017
    Assignee: Codexis, Inc.
    Inventors: Kaman Chan, Fernando Valle, Yoram Barak, Louis Clark, Kristian Karlshoej, Jonathan Vroom, Jovana Nazor, Claus M Krebber, Kenneth Mitchell
  • Low-phosphate repressible promoter
    Patent number: 9670493
    Abstract: The present invention provides compositions and methods comprising a low-phosphate repressible promoter. In particular, the present invention provides a low-phosphate repressible promoter from E. coli.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 6, 2017
    Assignee: Codexis, Inc.
    Inventors: Fernando Valle, Patricia Choudhary, Robert Osborne, Saul Nitsche Rocha, Monica Bhatia, U Loi Lao, Yihui Zhu
  • Production of fatty alcohols from engineered microorganisms
    Patent number: 9650655
    Abstract: Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a ?-ketoacyl acyl carrier protein synthase.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: May 16, 2017
    Assignee: Codexis, Inc.
    Inventors: Jonathan Vroom, Svetlana Balatskaya, Yoram Barak, Louis Clark, Trish Choudhary, Kristian Karlshoej, Fernando Valle, Kaman Chan
  • Method of creating a library of bacterial clones with varying levels of gene expression
    Patent number: 9534217
    Abstract: The present invention relates to a method of creating DNA libraries that include an artificial promoter library and/or a modified ribosome binding site library and transforming bacterial host cells with the library to obtain a population of bacterial clones having a range of expression levels for a chromosomal gene of interest.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: January 3, 2017
    Assignee: DANISCO US IN.
    Inventors: Philippe Soucaille, Marguerite A. Cervin, Fernando Valle
  • Modified native beta-ketoacyl-ACP synthases and engineered microorganisms
    Patent number: 9512447
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols and fatty acids. In particular, engineered microbial cells comprise a modified native gene having ?-ketoacyl-acp synthase activity.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: December 6, 2016
    Assignee: Codexis, Inc.
    Inventors: Smita Shankar, Louis Clark, Robert Osborne, Jonathan Vroom, Fernando Valle, Catherine M. Cho
  • Glucose and xylose co-utilization in
    Patent number: 9506087
    Abstract: The present invention provides host cells having improved sugar utilization or co-utilization, methods of producing host cells having improved sugar utilization or co-utilization, and methods of using host cells having improved sugar utilization or co-utilization. The present invention provides E. coli strains that co-utilize glucose and xylose in the presence of glucose and xylose, wherein the cell produces the product.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: November 29, 2016
    Assignee: Codexis, Inc.
    Inventors: Jonathan A. Vroom, Fernando Valle
  • COMPOSITIONS AND METHODS FOR PRODUCING ISOPRENE
    Publication number: 20160281113
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: January 4, 2016
    Publication date: September 29, 2016
    Inventors: Marguerite A. Cervin, Gopal K. Chotani, Frank J. Feher, Richard La Duca, Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Aaron S. Puhala, Karl J. Sanford, Fernando Valle, Gregory M. Whited