Abstract: A system for optical spectroscopy through a probe implanted in a tissue is provided. The system includes a light collecting probe comprising a waveguide formed by a single optical fiber and having a proximal end and a distal end, the proximal end being formed with a taper along which at least one optical window is positioned, wherein light entering at an axial section of the taper generates a specific subset of guided modes defined by the diameter of the single optical fiber at the axial section, the guided modes propagating toward the distal end of the waveguide and generating an output at the distal end of the waveguide; a demultiplexer configured to receive outputs provided by the light collecting probe and discriminate the outputs based on their modal content of origin; and a detector configured to detect the discriminated outputs.

Abstract: A system for optical spectroscopy through a probe (10) implanted in a tissue, the system including a light collecting probe (10) comprising a waveguide formed by a single optical fiber (11) and having a proximal end (11a) and a distal end (11b), the proximal end (11a) being formed with a taper (12) along which at least one optical window (11c) is positioned, wherein light entering at an axial section of the taper (12) generates a specific subset of guided modes defined by the diameter (a1, a2, . . . , an) of the optical fiber at that axial section, the guided modes propagating toward the distal end (11b) of the waveguide and generating an output (OUT) at the distal end of the waveguide; a demultiplexer (20) configured to receive outputs (OUT) provided by the probe (10) and discriminate the outputs (OUT) based on their modal content of origin; and a detector (30) configured to detect the discriminated outputs.

Abstract: A multi-point light-delivering device, comprising a waveguide carrying light along a longitudinal axis and including multiple optical windows, through which the carried light is out-coupled from the waveguide. The waveguide comprises a tapered region along which the optical windows are distributed, wherein each optical window out-couples a specific subset of propagating modes of the carried light, to which the optical window is matched.

Abstract: A multi-point light-delivering device, comprising a waveguide carrying light along a longitudinal axis and including multiple optical windows, through which the carried light is out-coupled from the waveguide. The waveguide comprises a tapered region along which the optical windows are distributed, wherein each optical window out-couples a specific subset of propagating modes of the carried light to which the optical window is matched.

Abstract: A method of identifying target analytes in a sample, particularly a biological sample, comprising the steps of putting a plurality of target analytes, bound to a common luminescent marker, in contact with a plurality of molecular probes immobilized on a support, each of said molecular probes being capable of complementary binding to a respective target analyte, if said target analyte is present in the sample, providing to said support an excitation radiation and detecting an emission radiation coming from said support as a result of at least one complementary binding event, characterized by the fact that: said support comprises a plurality of photonic crystal resonators, at least two of said resonators being characterized by different resonance wavelengths; each of said molecular probes being fixed to a respective resonator; and by the fact that the identification of at least one target analyte is carried out through the analysis of the total emission spectrum coming from said plurality of photonic crystal

Abstract: A method of identifying target analytes in a sample, particularly a biological sample, comprising the steps of putting a plurality of target analytes, bound to a common luminescent marker, in contact with a plurality of molecular probes immobilized on a support, each of said molecular probes being capable of complementary binding to a respective target analyte, if said target analyte is present in the sample, providing to said support an excitation radiation and detecting an emission radiation coming from said support as a result of at least one complementary binding event, characterized by the fact that: said support comprises a plurality of photonic crystal resonators, at least two of said resonators being characterized by different resonance wavelengths; each of said molecular probes being fixed to a respective resonator; and by the fact that the identification of at least one target analyte is carried out through the analysis of the total emission spectrum coming from said plurality of photonic crystal