Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: The present invention is a respiratory monitoring device which uses 2+ sensors to map respiratory motion in patients to interpret into a respiratory effort and severity score. The core components of the invention are contact-based sensors that measure relative motion of the chest, abdomen, and/or other key anatomical features, a processing unit which takes in the data from all sensors, an algorithm that analyzes and compares the data from each sensor to understand relative motion and interpret it into clinically-relevant information, and a display screen that shares this information with clinicians. The sensors are connected to each other and the information processing unit which shares data with the screen for display of a respiratory severity score based on analysis of Thoraco-Abdominal Asynchrony (TAA) or similar indicators of respiratory effort as measured by the sensor network and analyzed by the algorithm.

Abstract: The present invention is a respiratory monitoring device which uses 2+ sensors to map respiratory motion in patients to interpret into a respiratory effort and severity score. The core components of the invention are contact-based sensors that measure relative motion of the chest, abdomen, and/or other key anatomical features, a processing unit which takes in the data from all sensors, an algorithm that analyzes and compares the data from each sensor to understand relative motion and interpret it into clinically-relevant information, and a display screen that shares this information with clinicians. The sensors are connected to each other and the information processing unit which shares data with the screen for display of a respiratory severity score based on analysis of Thoraco-Abdominal Asynchrony (TAA) or similar indicators of respiratory effort as measured by the sensor network and analyzed by the algorithm.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: The present invention is a respiratory monitoring device which uses 2+ sensors to map respiratory motion in patients to interpret into a respiratory effort and severity score. The core components of the invention are contact-based sensors that measure relative motion of the chest, abdomen, and/or other key anatomical features, a processing unit which takes in the data from all sensors, an algorithm that analyzes and compares the data from each sensor to understand relative motion and interpret it into clinically-relevant information, and a display screen that shares this information with clinicians. The sensors are connected to each other and the information processing unit which shares data with the screen for display of a respiratory severity score based on analysis of Thoraco-Abdominal Asynchrony (TAA) or similar indicators of respiratory effort as measured by the sensor network and analyzed by the algorithm.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).