Abstract: A lateral flow test device includes a test chamber having a detection aperture. The lateral flow test device also includes an optical detector configured to receive light from an assay test strip through the detection aperture when the assay test strip is provided in the test chamber. The test chamber is configured for manual feed of at least a portion of the assay test strip passed the detection aperture. The optical detector is configured to detect one or more tracking features associated with the assay test strip so as to determine when at least a test line on the assay test strip is detectable through the detection aperture.

Abstract: An optical module for reading a test region of an assay includes a near-infrared light source for illuminating the test region of the assay with light in a near-infrared spectrum. The optical module also includes an optical detector. The optical detector includes an optical input for receiving light emitted from the test region of the assay and an electrical output. The optical module further includes an electrical signal processor electrically coupled to the electrical output. The optical module additionally includes one or more optical filter arranged in front of the optical input of the optical detector.

Abstract: An optical module (100) for reading a test region of an assay. The optical module comprises: a first light source (101) for illuminating the test region of the assay; an optical detector (103), comprising an optical input for receiving light emitted from the test region and an electrical output; a substrate (104) for mounting the first light source (101) and the optical detector (103); and a housing (105) comprising: a first opening (106) for providing a first optical path from the first light source (101) to the test region (103); wherein the housing (105) and the substrate (104) enclose and positionally align the first source (101) and the optical detector (103) relative to the first opening (106). The housing (105) may comprise one or more legs (108), such as a flexible hook portion which secures the housing (105) to the substrate (104) with a snap-fit engagement, extending from a first and/or second outer surface of the housing (105) in a vertical direction.

Abstract: A gas sensor comprises an electrochemical film, a plurality of electrodes coupled with the electrochemical film and a semiconductor wafer coupled with the plurality of electrodes. A passivation layer is formed between the electrochemical firm and the semiconductor wafer and a dielectric layer is coupled between the electrochemical film and the semiconductor wafer.

Abstract: A particle detector. The particle detector comprises one or more light sources, an optical sensor, and a controller. The one or more light sources are collectively operable to simultaneously produce at least two wavelength ranges of emitted light. The optical sensor is configured to sense light of the at least two wavelength ranges emitted by the one or more light sources and to distinguish each range. The controller is configured to detect particles based on the light sensed by the optical sensor.

Abstract: Apparatus for reading a test region (6, 7) of an assay, e.g. on a lateral flow test strip (5), the apparatus comprising: an optical detector (2, 4; FIG. 1c), comprising an optical input for receiving light emitted from the test region (6, 7) of the assay and an electrical output; an electrical signal processor, electrically coupled to the electrical output; and a plurality of spectral filters (FIG. 1b) substantially transparent to a plurality of different wavelengths.

Abstract: A gas sensor comprises an electrochemical film, a plurality of electrodes coupled with the electrochemical film and a semiconductor wafer coupled with the plurality of electrodes. A passivation layer is formed between the electrochemical firm and the semiconductor wafer and a dielectric layer is coupled between the electrochemical film and the semiconductor wafer.

Abstract: A method for providing an integrated circuit such that first and second sensing electrodes respectively have at their surfaces first and second receptor molecules for selectively binding to first and second analytes of interest; exposing the integrated circuit to a sample potentially comprising at least one of the first and second analytes, providing a first bead having a first electrical signature attached to a first molecule having a conformation/affinity for binding to the first sensing electrode dependent on the presence of the first analyte; providing a second bead having a second electrical signature attached to a second molecule having a conformation/affinity for binding to the second sensing electrode dependent on the presence of the second analyte; and determining the presence of the electrical signature of the first and/or second bead(s) on the first and second sensing electrodes respectively. An IC for implementing this method.

Abstract: One example discloses a handheld medical device, comprising: a patient attribute sensor input configured to receive a patient attribute input signal; a dosage calculator configured to output a prescribed dosage volume output signal in response to the patient attribute input signal; a dosage volume sensor input configured to receive an actual dosage volume input signal; and a dosage comparator configured to generate a comparator output signal based on a comparison between the prescribed dosage volume output signal and the actual dosage volume input signal.

Abstract: There is provided a lateral flow immunoassay test device. The test device comprises a test strip. The test strip comprises a test membrane having a translucent section including a control zone and a test zone. The device is adapted to house the test strip such that at least the translucent section is exposable to ambient light. The device comprises a backing structure for backing the test strip which comprises a first optical detector for detecting ambient light which has passed through the test zone, and a second optical detector for detecting ambient light which has passed through the translucent section in a further zone outside of the test and control zones. Using the detector outputs an amount of analyte in a test liquid may be calculated.

Abstract: The present invention relates to a sensing device with a surface having at least one individual sensing region, wherein each sensing region includes a plurality of binding elements anchored on the surface for binding different specific analytes of interest, at least one of the analyte of interest and its matching binding element having a label for detecting said binding. The present invention further relates to a method of manufacturing such a sensing device.

Abstract: As may be implemented with one or more embodiments herein, aspects of the disclosure are directed to an apparatus having one or more sensor circuits and a wound-characterization circuit that generates data that characterizes a condition of the wound based on physiological characteristics detected by the sensors. A wireless communication circuit wirelessly transmits the characterization data, which can be carried out while the wound is covered. In various implementations, an integration circuit (e.g., connecting circuitry and/or a chip) includes the wound-characterization circuit and the sensor circuit, and further couples to a wound dressing for sensing the different physiological characteristics of the wound while the wound dressing covers a portion of the wound from which the different physiological characteristics are sensed.

Abstract: There is provided a lateral flow immunoassay test device. The test device comprises a test strip. The test strip comprises a test membrane having a translucent section including a control zone and a test zone. The device is adapted to house the test strip such that at least the translucent section is exposable to ambient light. The device comprises a backing structure for backing the test strip which comprises a first optical detector for detecting ambient light which has passed through the test zone, and a second optical detector for detecting ambient light which has passed through the translucent section in a further zone outside of the test and control zones. Using the detector outputs an amount of analyte in a test liquid may be calculated.

Abstract: A method for providing an integrated circuit such that first and second sensing electrodes respectively have at their surfaces first and second receptor molecules for selectively binding to first and second analytes of interest; exposing the integrated circuit to a sample potentially comprising at least one of the first and second analytes, providing a first bead having a first electrical signature attached to a first molecule having a conformation/affinity for binding to the first sensing electrode dependent on the presence of the first analyte; providing a second bead having a second electrical signature attached to a second molecule having a conformation/affinity for binding to the second sensing electrode dependent on the presence of the second analyte; and determining the presence of the electrical signature of the first and/or second bead(s) on the first and second sensing electrodes respectively. An IC for implementing this method.

Abstract: In one aspect, this disclosure provides a substrate for determining the concentration of an analyte within a sample. The substrate includes a conductive region and a recognition layer, the conductive region including at least one particle and having a first surface operatively coupled with the recognition layer, the recognition layer comprising at least one recognition molecule. The distance between the first surface of the conductive region and the recognition molecule is selected such that when the analyte is bound to the recognition layer the combination of the at least one particle and the analyte exhibits at least one of the following effects when radiation is directed through the conductive region and the recognition layer: (i) a particle plasmon effect, (ii) a particle bulk interband absorption, (iii) analyte molecular absorption, and (iv) absorption by the analyte-particle combination.

Abstract: A sensor device is disclosed, which depends on discrimination in time between groups of binding events of target particles to nano-electrodes. The target particles may be in the liquid phase or in suspension. The nano-electrodes form part of a sensor arrangement having a plurality of sensors. The sensor device is arranged such that different species of target particles arrive at the nano-electrodes at different times, using techniques such as chromatography or application of a field such as an electric, magnetic, or gravitational field. The particles may be labelled or unlabeled. The invention is particularly suited, but not limited, to sensing bioparticles.

Abstract: In one aspect, this disclosure provides a substrate for determining the concentration of an analyte within a sample. The substrate includes a conductive region and a recognition layer, the conductive region including at least one particle and having a first surface operatively coupled with the recognition layer, the recognition layer comprising at least one recognition molecule. The distance between the first surface of the conductive region and the recognition molecule is selected such that when the analyte is bound to the recognition layer the combination of the at least one particle and the analyte exhibits at least one of the following effects when radiation is directed through the conductive region and the recognition layer: (i) a particle plasmon effect, (ii) a particle bulk interband absorption, (iii) analyte molecular absorption, and (iv) absorption by the analyte-particle combination.

Abstract: A device for bio-sensing applications is disclosed, comprising a substrate such as a semiconductor chip having Cu electrodes thereon, and a self assembled monolayer bonded to at least one of the Cu electrodes, wherein molecules of the self-assembled monolayer comprise a head group which bonds to Cu, a carbon-comprising chain comprising a chain of at least 12 C atoms, and a terminal group which is hydrophilic and for binding a bio-receptor. The terminal group is hydrophilic to allow binding to the bio-receptor, and inclusion of the carbon-comprising chain, limits or avoids corrosion of the copper. Also disclosed is a method of providing such a device, activating the terminal group and coupling a bio-receptor to the activated terminal group. Disclosure further extends to use of such a device for bio-sensing applications.

Abstract: An article is provided for immobilizing functional organic biomolecules (e.g. proteins, DNA, and the like) through a covalent bond to a thiolate or disulfide monolayer to a metal surface wherein an extra activation step of the surface layer or an activation step of the functional biomolecules or bioreceptors could be avoided. The monolayer can contain, but is not limited to, two moieties. One has a group that resists nonspecific adsorption and another has a group that directly (without activation) reacts with functional groups on the biomolecules. In addition, poly(ethylene oxide) groups are incorporated in the monolayer surfaces to resist the nonspecific adsorption and to enhance the specific affinity interactions. A sensor device including these monolayers is also provided to perform reproducible, sensitive, specific and stable bioanalysis.

Abstract: The present invention relates to a sensing device with a surface having at least one individual sensing region, wherein each sensing region includes a plurality of binding elements anchored on the surface for binding different specific analytes of interest, at least one of the analyte of interest and its matching binding element having a label for detecting said binding. The present invention further relates to a method of manufacturing such a sensing device.