Patents by Inventor Filippo NISIC

Filippo NISIC has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates
    Patent number: 11053227
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: July 6, 2021
    Assignee: OLON S.P.A.
    Inventors: Corrado Colli, Giorgio Bertolini, Mara Sada, Faris Garis, Filippo Nisic, Aldo Bianchi, Cinzia Biaggi, Romano Di Fabio, Silvano Ronzoni, Stefania Bertuolo, Adolfo Prandi, Stefano Maiorana
  • Process for the preparation of a novel umeclidinium synthesis intermediate
    Patent number: 11028082
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: June 8, 2021
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Filippo Nisic, Mara Sada, Stefania Bertuolo, Silvano Ronzoni, Stefano Maiorana, Romano Di Fabio
  • PROCESS FOR THE SYNTHESIS OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS
    Publication number: 20210061757
    Abstract: Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invention are said novel synthesis intermediates and their use for the preparation of active pharmaceutical ingredients.
    Type: Application
    Filed: April 11, 2019
    Publication date: March 4, 2021
    Inventors: Filippo NISIC, Faris GARIS, Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Romano DI FABIO, Stefano MAIORANA
  • PROCESS FOR PREPARING INTERMEDIATES FOR THE SYNTHESIS OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS BY ENZYMATIC REDUCTION AND NOVEL SYNTHESIS INTERMEDIATES
    Publication number: 20200385366
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 10, 2020
    Inventors: Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Faris GARIS, Filippo NISIC, Aldo BIANCHI, Cinzia BIAGGI, Romano DI FABIO, Silvano RONZONI, Stefania BERTUOLO, Adolfo PRANDI, Stefano MAIORANA
  • PROCESS FOR THE PREPARATION OF A NOVEL UMECLIDINIUM SYNTHESIS INTERMEDIATE
    Publication number: 20200102300
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 2, 2020
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Filippo NISIC, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Stefano MAIORANA, Romano DI FABIO
  • Process for the preparation of indanamine derivatives and new synthesis intermediates
    Patent number: 10059653
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: August 28, 2018
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Paolangelo Cerea, Corrado Colli, Lazzaro Feliciani, Federico Gassa, Aldo Bianchi, Federica Colombo, Stefano Maiorana, Filippo Nisic
  • Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters
    Patent number: 10023535
    Abstract: The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 17, 2018
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Aldo Bianchi, Federica Colombo, Stefano Maiorana, Filippo Nisic
  • PROCESS FOR THE PREPARATION OF INDANAMINE DERIVATIVES AND NEW SYNTHESIS INTERMEDIATES
    Publication number: 20170362161
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Application
    Filed: January 19, 2016
    Publication date: December 21, 2017
    Applicant: OLON S.P.A.
    Inventors: Giorgio BERTOLINI, Paolangelo CEREA, Corrado COLLI, Lazzaro FELICIANI, Federico GASSA, Aldo BIANCHI, Federica COLOMBO, Stefano MAIORANA, Filippo NISIC
  • METHOD FOR THE PREPARATION OF 1-(2-HALOGEN-ETHYL)-4 PIPERIDINE-CARBOXYLIC ACID ETHYL ESTERS
    Publication number: 20170313657
    Abstract: The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.
    Type: Application
    Filed: October 22, 2015
    Publication date: November 2, 2017
    Applicant: OLON S.P.A.
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Aldo BIANCHI, Federica COLOMBO, Stefano MAIORANA, Filippo NISIC