Patents by Inventor Filippo Sladojevich

Filippo Sladojevich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Synthesis of Phosphorodithioate Oligonucleotides
    Publication number: 20240084295
    Abstract: The invention provides the use of a compound of formula (I), as defined, for the preparation of an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage. Various synthesis methods using compounds of formula (I) are provided.
    Type: Application
    Filed: August 29, 2023
    Publication date: March 14, 2024
    Inventors: Martin Bollmark, Walter Fernando Sehgelmeble Torrejon, Filippo Sladojevich, Ulf Tedebark
  • QUALITY CONTROL OF LNA OLIGONUCLEOTIDE THERAPEUTICS USING MASSIVELY PARALLEL SEQUENCING
    Publication number: 20220002796
    Abstract: The invention relates to the field of therapeutic oligonucleotide analytics, and provides methods for primer based parallel sequencing of therapeutic oligonucleotides which provide sequence based quality information which may be used in conjunction with or in place of present chromatography or mass spectroscopic methods, and may be used, for example, in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.
    Type: Application
    Filed: May 6, 2019
    Publication date: January 6, 2022
    Applicant: Roche Innovation Center Copenhagen A/S
    Inventors: Mads JENSEN, Jonas VIKESAA, Lukasz KIELPINSKI, Lars JOENSON, Filippo SLADOJEVICH
  • PROCESS FOR THE PURIFICATION OF OLIGONUCLEOTIDES
    Publication number: 20210347800
    Abstract: The invention relates to a new process for the purification of oligonucleotides which comprises the removal of the acid labile 5?hydroxy protecting group at the 5?-O-oligonucleotide terminus of the oligonucleotide by way of tangential flow filtration with an acidic buffer solution. The process requires less steps and allows a higher degree of automation.
    Type: Application
    Filed: April 21, 2021
    Publication date: November 11, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg LILL, Filippo SLADOJEVICH
  • MASSIVELY PARALLEL DISCOVERY METHODS FOR OLIGONUCLEOTIDE THERAPEUTICS
    Publication number: 20210269851
    Abstract: The invention relates to the field of therapeutic oligonucleotide analytics and discovery, and provides methods for primer based parallel sequencing of modified oligonucleotides which provide sequence based quality information which may be used in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.
    Type: Application
    Filed: May 6, 2019
    Publication date: September 2, 2021
    Applicant: Roche Innovation Center Copenhagen A/S
    Inventors: Mads JENSEN, Lars JOENSON, Lukasz KIELPINSKI, Jonas VIKESAA, Filippo SLADOJEVICH
  • MASSIVELY PARALLEL DISCOVERY METHODS FOR OLIGONUCLEOTIDE THERAPEUTICS
    Publication number: 20210071247
    Abstract: The invention relates to the field of therapeutic oligonucleotide analytics and discovery, and provides methods for primer based parallel sequencing of modified oligonucleotides which provide sequence based quality information which may be used in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.
    Type: Application
    Filed: May 6, 2019
    Publication date: March 11, 2021
    Applicant: Roche Innovation Center Copenhagen A/S
    Inventors: Mads JENSEN, Jonas VIKESAA, Lukasz KIELPINSKI, Lars JOENSON, Filippo SLADOJEVICH
  • LNA-DICARBOXYLIC ACID DERIVATIVES AND PROCESS FOR THEIR PREPARATION
    Publication number: 20200407392
    Abstract: The invention comprises LNA-dicarboxylic acid derivatives of the formula I or salts thereof, wherein R1 is a nucleobase or a modified nucleobase R2 is a hydroxy protecting group and n is an integer from 1 to 5. The LNA-dicarboxylic acid derivatives of the formula I can be used in preloaded solid supports of the formula III and as that serve as suitable start material for oligonucleotide synthesis.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 31, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: KURT PUENTENER, CHRISTOPH ROSENBOHM, FILIPPO SLADOJEVICH
  • HETEROCYLIC COMPOUNDS CONTAINING THE MORPHOLINE NUCLEUS THEIR PREPARATION AND USE
    Publication number: 20100087326
    Abstract: Herein are described heterocyclic compounds containing the morpholine nucleus prepared from amino acids, their preparation and use for therapeutic applications.
    Type: Application
    Filed: April 18, 2008
    Publication date: April 8, 2010
    Inventors: Antonio Guarna, Andrea Trabocchi, Gloria Menchi, Claudia Lalli, Filippo Sladojevich, Nicoletta Cini