Patents by Inventor Filippo Tomasi

Filippo Tomasi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dimer impurities of Apixaban and method to remove them
    Patent number: 10590133
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: March 17, 2020
    Assignee: F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi, Loris Peruzzi
  • DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM
    Publication number: 20190367509
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 5, 2019
    Inventors: Elena BRASOLA, Filippo Tomasi, Loris Peruzzi
  • Dimer impurities of apixaban and method to remove them
    Patent number: 10385049
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: August 20, 2019
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi, Loris Peruzzi
  • Key intermediates and impurities of the synthesis of Apixaban: Apixaban glycol esters
    Patent number: 10040793
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: August 7, 2018
    Assignee: F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi
  • DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM
    Publication number: 20180118737
    Abstract: Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
    Type: Application
    Filed: July 18, 2016
    Publication date: May 3, 2018
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena BRASOLA, Filippo TOMASI, Loris PERUZZI
  • KEY INTERMEDIATES AND IMPURITIES OF THE SYNTHESIS OF APIXABAN: APIXABAN GLYCOL ESTERS
    Publication number: 20180086759
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Application
    Filed: November 30, 2017
    Publication date: March 29, 2018
    Inventors: Elena BRASOLA, Filippo TOMASI
  • Key intermediates and impurities of the synthesis of apixaban: apixaban glycol esters
    Patent number: 9920051
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: March 20, 2018
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Elena Brasola, Filippo Tomasi
  • Key intermediates and impurities of the synthesis of Apixaban: Apixaban glycol esters
    Patent number: 9624221
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: April 18, 2017
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A
    Inventors: Elena Brasola, Filippo Tomasi
  • KEY INTERMEDIATES AND IMPURITIES OF THE SYNTHESIS OF APIXABAN: APIXABAN GLYCOL ESTERS
    Publication number: 20170001999
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban kinetic Apixaban are also identified and quantified.
    Type: Application
    Filed: February 18, 2015
    Publication date: January 5, 2017
    Inventors: Elena BRASOLA, Filippo TOMASI
  • KEY INTERMEDIATES AND IMPURITIES OF THE SYNTHESIS OF APIXABAN: APIXABAN GLYCOL ESTERS
    Publication number: 20160326171
    Abstract: Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 10, 2016
    Inventors: Elena BRASOLA, Filippo TOMASI
  • Process for the synthesis of quetiapine
    Patent number: 8389716
    Abstract: The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: March 5, 2013
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Siro Serafini, Filippo Tomasi, Marco Galvagni
  • PROCESS FOR THE SYNTHESIS OF QUETIAPINE
    Publication number: 20110118460
    Abstract: The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.
    Type: Application
    Filed: January 30, 2009
    Publication date: May 19, 2011
    Inventors: Siro Serafini, Filippo Tomasi, Marco Galvagni