Abstract: The present invention relates to certain pyrazolo[1,5a]pyrimidine compounds, to processes for their preparation, compositions comprising them and methods of using them. The compounds are useful in the treatment of cancer. Novel screening methods are also provided.

Abstract: The present invention relates to a method of indentifying an agent that modulates the function of an apoptosos-associated polypeptide having a sequence as set out in Table 1, the method comprising: (a) providing a sample containing an apoptosis-associated polypeptide having a sequence as set out in Table 1, and a candidate agent and incubating under conditions to permit binding of the candidate agent to the polypeptide; (b) measuring the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1 to the candidate agent in the sample; and (c) comparing the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1 to the candidate agent in the sample with the binding of the polypeptide having a sequence as set out in Table 1; wherein an increase in the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1 to the candidate agent in the sample relative to the binding of the apoptosis-associated polypeptide having a sequenc

Abstract: The present invention relates to methods of identifying an agent that modulates the function of an apoptosis-associated polypeptide having a sequence as set out in Table 1B. The invention also relates to methods of modulating apoptosis, diagnostic methods, arrays, kits and compositions based upon the apoptosis-associated polypeptides having sequences as set out in Table 1B and in FIG. 42.

Abstract: The present invention relates to methods of identifying an agent that modulates the function of an apoptosis-associated polypeptide having a sequence as set out in Table 1B. The invention also relates to methods of modulating apoptosis, diagnostic methods, arrays, kits and compositions based upon the apoptosis-associated polypeptides having sequences as set out in Table 1B.

Abstract: The present invention relates to a method for identifying a gene product which modulates the transition of a cell between a non-apoptopic state and an apoptopic state, comprising the steps of: (a) exposing the cell to an inhibitor of GM-CSF mediated inhibition of apoptosis; and (b) exposing the cell to one or more agents which increase tyrosine phosphorylation; and (c) C) placing the cell in conditions which permit it to undergo spontaneous apoptosis; and (d) monitoring the level(s) of expression of the one or more gene products in the cell; and (e) identifying gene product(s) whose expression has been increased, decreased or modified as a result of performing steps (a) to (d).