Patents by Inventor Finn HAWKINS

Finn HAWKINS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation of human lung progenitors derived from pluripotent stem cells
    Patent number: 11366115
    Abstract: Provided herein are methods and compositions relating, in part, to the generation and isolation of human lung progenitor cells from pluripotent stem cells.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: June 21, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. Kotton, Finn Hawkins
  • Generation of airway epithelial organoids from human pluripotent stem cells
    Patent number: 10590392
    Abstract: The technology described herein relates to methods and kits for directed differentation of primordial NKX2-1+ lung progenitors along proximal differentiation pathways into functional airway epithelial cells and airway organoids (“bronchospheres”) or along distal lineage pathways using modulation of Wnt signaling. Other aspects relate cell lines, methods, assays and kits comprising airway epithelial cells, and assays for diagnosing a disease that affects swelling of the bronchospheres, and/or for assessing genetic lesions and/or drugs for treating the the disease, where the disease is cystic fibrosis. Other aspects relate to personalized medicine and methods of treatment of cystic fibrosis using the airway epithelial cells.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: March 17, 2020
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. Kotton, Katherine B. McCauley, Finn Hawkins
  • ISOLATION OF HUMAN LUNG PROGENITORS DERIVED FROM PLURIPOTENT STEM CELLS
    Publication number: 20200003776
    Abstract: Provided herein are methods and compositions relating, in part, to the generation and isolation of human lung progenitor cells from pluripotent stem cells.
    Type: Application
    Filed: July 2, 2019
    Publication date: January 2, 2020
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. Kotton, Finn Hawkins
  • Isolation of human lung progenitors derived from pluripotent stem cells
    Patent number: 10386368
    Abstract: Provided herein are methods and compositions relating, in part, to the generation and isolation of human lung progenitor cells from pluripotent stem cells.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: August 20, 2019
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. Kotton, Finn Hawkins
  • ISOLATION OF HUMAN LUNG PROGENITORS DERIVED FROM PLURIPOTENT STEM CELLS
    Publication number: 20180246099
    Abstract: Provided herein are methods and compositions relating, in part, to the generation and isolation of human lung progenitor cells from pluripotent stem cells.
    Type: Application
    Filed: February 22, 2018
    Publication date: August 30, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. Kotton, Finn Hawkins
  • GENERATION OF AIRWAY EPITHELIAL ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS
    Publication number: 20180208903
    Abstract: The technology described herein relates to methods and kits for directed differentation of primordial NKX2-1+ lung progenitors along proximal differentiation pathways into functional airway epithelial cells and airway organoids (“bronchospheres”) or along distal lineage pathways using modulation of Wnt signaling. Other aspects relate cell lines, methods, assays and kits comprising airway epithelial cells, and assays for diagnosing a disease that affects swelling of the bronchospheres, and/or for assessing genetic lesions and/or drugs for treating the the disease, where the disease is cystic fibrosis. Other aspects relate to personalized medicine and methods of treatment of cystic fibrosis using the airway epithelial cells.
    Type: Application
    Filed: January 9, 2018
    Publication date: July 26, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. KOTTON, Katherine B. McCauley, Finn HAWKINS