Patents by Inventor Fiona A. O. Marston

Fiona A. O. Marston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5340926
    Abstract: In a process for the production of a soluble native protein, such as immunoglobulin or methionine-prochymosin, in which an insoluble form of the protein is produced by a host organism transformed with a vector including a gene coding for the protein, the insoluble form of the protein is reversibly denatured in an alkaline aqueous solution at a pH selected to promote dissociation of a group or groups of the protein involved in maintaining the conformation of the protein, and the protein is subsequently allowed to renature by reducing the pH of the solution below a pH effective to denature the protein to produce the soluble native form of the protein. The pH of the alkaline aqueous is suitably in the range 9.0 to 11.5.
    Type: Grant
    Filed: August 5, 1993
    Date of Patent: August 23, 1994
    Assignee: Celltech, Limited
    Inventors: Peter A. Lowe, Fiona A. O. Marston, Sarojani Angal, Joyce A. Schoemaker