Patents by Inventor Fiona Ginty
Fiona Ginty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250102507Abstract: A method for providing a composite image of a single biological sample, comprising the steps of generating a first image of the biological sample with a target protein, generating a second image of the biological sample with a target nucleic acid sequence, and generating a composite image that provides the relative locations of both the target protein and the target nucleic acid sequence. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein and the nucleic acid sequences of interest from the composite image. Further provided are systems and kits that comprise the means for executing the novel methods.Type: ApplicationFiled: August 30, 2024Publication date: March 27, 2025Inventors: Antti E. SEPPO, Fiona GINTY, Kevin B. KENNY, David Lavan HENDERSON, Michael J. GERDES, Adriana I. LARRIERA MORENO, Xiaofeng LIU, Alex D. CORWIN, Stephen E. ZINGELEWICZ, Thomas HA, Natalia R. JUN, Ainura KYSHTOOBAYEVA, Denise A. HOLLMAN-HEWGLEY, Ying LI
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Publication number: 20250095642Abstract: The current disclosure provides methods for an automated clinical recommendation system that generates clinical recommendations for patients of a health care system based on natural language queries submitted by care providers of the health care system. The natural language queries may be typed into a user interface (UI) of the clinical recommendation system, or submitted by voice via a microphone. The clinical recommendation system provides a clinically explainable disease state of a patient based on patient data included in a query, and recommends a next course of action (e.g., a treatment) based on clinical guidelines and population statistics, in a manner that reduces a current burden of clinicians in consulting digital clinical manuals via a series of time-consuming and cumbersome interactions with a graphical user interface (GUI) of the digital clinical manuals.Type: ApplicationFiled: September 15, 2023Publication date: March 20, 2025Inventors: Soumya Ghose, Sanand Sasidharan, Sanghee Cho, Akshit Achara, Rakesh Mullick, Anuradha Kanamarlapudi, Fiona Ginty, Annamraju Ravi Bhardwaj, Sundararajan Mani, Brion Sarachan
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Publication number: 20240033092Abstract: The present discussion relates to the design fabrication and use of synthetic scaffold structure for bone growth. In certain implementations the scaffold structures are comprised of a plurality of repeating structures each defined by a local topology. The local topologies are defined at a subset of points in their respective volumes by various parameters including, but not limited to, shape index, curvedness, mean curvature, and Gauss curvature.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Inventors: Gautam Parthasarathy, Daniel J. Erno, Chitresh Bhushan, Cathleen Ann Hoel, Sara Kelly Peterson, Jessica Susanne Martinez, Brian Michael Davis, Steven Jude Duclos, Fiona Ginty
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Publication number: 20230317293Abstract: A method for determining a recurrence of a disease in a patient is presented. The method includes generating a plurality of medical images of an organ of the patient and determining a plurality of recurrence probabilities from the plurality of medical images. A recurrence of the disease is determined based on the plurality of recurrence probabilities and clinicopathological data of the patient using a Bayesian network.Type: ApplicationFiled: March 31, 2022Publication date: October 5, 2023Inventors: Sanghee Cho, Zhanpan Zhang, Soumya Ghose, Fiona Ginty, Cynthia Elizabeth Landberg Davis, Jhimli Mitra, Sunil S. Badve, Yesim Gokmen-Polar
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Publication number: 20230309836Abstract: A method for determining a recurrence of a disease in a patient is presented. The method includes generating a plurality of medical images of an organ of the patient and determining a plurality of recurrence probabilities from the plurality of medical images. A recurrence of the disease is determined based on the plurality of recurrence probabilities and clinicopathological data of the patient using a Bayesian network.Type: ApplicationFiled: November 7, 2022Publication date: October 5, 2023Applicant: The Trustees of Indiana UniversityInventors: Souyma Ghose, Zhanpan Zhang, Sanghee Cho, Fiona Ginty, Cynthia Elizabeth Landberg Davis, Jhimli Mitra, Sunil S. Badve, Yesim Gokmen-Polar, Elizabeth Mary McDonough
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Publication number: 20230307137Abstract: A method for determining a recurrence of a disease in a patient includes generating a medical image of an organ of the patient and then extracting an invasive edge around an area of interest in the medical image. A plurality of radiomics features is obtained from the invasive edge and the recurrence of the disease is determined based on the plurality of radiomics features.Type: ApplicationFiled: March 25, 2022Publication date: September 28, 2023Inventors: Soumya Ghose, Fiona Ginty, Cynthia Elizabeth Landberg Davis, Sanghee Cho, Sunil S. Badve, Yesim Gokmen-Polar
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Patent number: 11573235Abstract: A method for generating an image of a region of interest in a biological sample comprising the steps of: generating a first image including the region of interest of the biological sample having undergone a first protocol but not a second protocol; and generating a second image including the region of interest of the biological sample after having undergone a second protocol; wherein the region of interest is smaller than said sample. Also provided is a method of analyzing a biological sample, comprising providing an image of the biological sample according to the method for generating an image of a region of interest in a biological sample, and analyzing the biological sample from the image. Further provided are system and kit that comprise the means for executing the novel methods.Type: GrantFiled: March 21, 2013Date of Patent: February 7, 2023Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Antti E. Seppo, Fiona Ginty, Kevin B. Kenny, David Lavan Henderson, Michael J. Gerdes, Adriana Ines Larriera, Xiaofeng Liu, Alex D. Corwin, Stephen E. Zingelewicz, Thomas Ha, Natalia R. Jun, Ainura Kyshtoobayeva, Denise A. Hollman-Hewgley, Ying Li
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Publication number: 20200174000Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistance to the treatment, prevention, and diagnosis of diseases/symptoms related to ductal carcinoma in situ (DCIS). Embodiments include methods of detecting and/or treating diseases/symptoms related to ductal carcinoma in situ (DCIS), comprising the steps of: providing a sample of blood, cells, or tissue from a person suspected of having ductal carcinoma in situ; and detecting one or more epithelial markers in the sample.Type: ApplicationFiled: December 2, 2019Publication date: June 4, 2020Applicant: The Trustees of Indiana UniversityInventors: Sunil S Badve, Yesmin Gokmen-Polar, Adrian L Harris, Fiona Ginty, Sanghee Cho
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Patent number: 10423820Abstract: The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.Type: GrantFiled: September 13, 2017Date of Patent: September 24, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Alberto Santamaria-Pang, Qing Li, Yunxia Sui, Dmitry Vladimirovich Dylov, Christopher James Sevinsky, Michael E. Marino, Michael J. Gerdes, Daniel Eugene Meyer, Fiona Ginty, Anup Sood
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Publication number: 20190080146Abstract: The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.Type: ApplicationFiled: September 13, 2017Publication date: March 14, 2019Inventors: Alberto Santamaria-Pang, Qing Li, Yunxia Sui, Dmitry Vladimirovich Dylov, Christopher James Sevinsky, Michael E. Marino, Michael J. Gerdes, Daniel Eugene Meyer, Fiona Ginty, Anup Sood
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Patent number: 10082451Abstract: The present invention provides a microscope slide for analyzing a tissue sample. The slide includes an elongate planar substrate, which comprises a first major surface having a sample-affixing area within which a tissue sample may be affixed; a first positive control sample affixed on the first major surface at a first location adjacent to the sample-affixing area; and a second positive control sample affixed on the first major surface at a second location adjacent to the sample-affixing area. The first and second locations are spaced such that quality of the staining of the first and second positive control samples is indicative of the quality of the staining of the tissue sample. Also provided are a kit containing the microscope slide and a method of making and a method of using the microscope slide.Type: GrantFiled: March 20, 2014Date of Patent: September 25, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Rui Chen, Zhengyu Pang, Colin Craig McCulloch, Michael Lazare, Robert John Filkins, Fiona Ginty
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Patent number: 10019796Abstract: Disclosed are novel computer-implemented methods for creating a blood vessel map of a biological tissue. The methods comprise the steps of, accessing image data corresponding to multi-channel multiplexed image of a fluorescently stained biological tissue manifesting expression levels of a primary marker and at least one auxiliary marker of blood vasculature, and extracting features of blood vessels using the primary marker as an input to create a single channel segmentation of the blood vessels. The method further comprises the steps of extracting features of blood vessels using the auxiliary marker to create auxiliary channels as a second input and apply multi-channel blood vessel enhancement. Blood vessel maps are created using the features and tracing the blood vasculature by iteratively extending the centerlines of the initial segmentation using statistical models and geometric rules.Type: GrantFiled: September 20, 2016Date of Patent: July 10, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Yousef Al-Kofahi, Anup Sood, Fiona Ginty, Qing Li, Christopher James Sevinsky, Alberto Santamaria-Pang
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Patent number: 9984199Abstract: The disclosed embodiments are directed to a method for accurately counting and characterizing multiple cell phenotypes and sub-phenotypes within cell populations simultaneously by exploiting biomarker co-expression levels within cells of different phenotypes in the same tissue sample. The disclosed embodiments are also directed to a simple intuitive interface enabling medical staff (e.g., pathologists, biologists) to annotate and evaluate different cell phenotypes used in the algorithm and the presented through the interface.Type: GrantFiled: May 21, 2015Date of Patent: May 29, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Anup Sood, Fiona Ginty, Nicole Evelyn LaPlante, Christopher James Sevinsky, Qing Li, Alberto Santamaria-Pang, Raghav Krishna Padmanabhan
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Patent number: 9778263Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a distribution, location, and type of a plurality of the characterized cells.Type: GrantFiled: November 13, 2013Date of Patent: October 3, 2017Assignee: General Electric CompanyInventors: Srabani Bhaumik, Michael John Gerdes, Zhengyu Pang, Fiona Ginty, Christopher James Sevinsky, Qing Li, Alberto Santamaria-Pang, Yunxia Sui, Keyur Hemantkumar Desai
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Publication number: 20170109880Abstract: Disclosed are novel computer-implemented methods for creating a blood vessel map of a biological tissue. The methods comprise the steps of, accessing image data corresponding to multi-channel multiplexed image of a fluorescently stained biological tissue manifesting expression levels of a primary marker and at least one auxiliary marker of blood vasculature, and extracting features of blood vessels using the primary marker as an input to create a single channel segmentation of the blood vessels. The method further comprises the steps of extracting features of blood vessels using the auxiliary marker to create auxiliary channels as a second input and apply multi-channel blood vessel enhancement.Type: ApplicationFiled: September 20, 2016Publication date: April 20, 2017Inventors: Yousef Al-Kofahi, Anup Sood, Fiona Ginty, Qing Li, Christopher James Sevinsky, Alberto Santamaria-Pang
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Publication number: 20160341731Abstract: The disclosed embodiments are directed to a method for accurately counting and characterizing multiple cell phenotypes and sub-phenotypes within cell populations simultaneously by exploiting biomarker co-expression levels within cells of different phenotypes in the same tissue sample. The disclosed embodiments are also directed to a simple intuitive interface enabling medical staff (e.g., pathologists, biologists) to annotate and evaluate different cell phenotypes used in the algorithm and the presented through the interface.Type: ApplicationFiled: May 21, 2015Publication date: November 24, 2016Inventors: Anup Sood, Fiona Ginty, Nicole Evelyn LaPlante, Christopher James Sevinsky, Qing Li, Alberto Santamaria-Pang, Raghav Krishna Padmanabhan
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Publication number: 20160274008Abstract: The present invention provides a microscope slide for analyzing a tissue sample. The slide includes an elongate planar substrate, which comprises a first major surface having a sample-affixing area within which a tissue sample may be affixed; a first positive control sample affixed on the first major surface at a first location adjacent to the sample-affixing area; and a second positive control sample affixed on the first major surface at a second location adjacent to the sample-affixing area. The first and second locations are spaced such that quality of the staining of the first and second positive control samples is indicative of the quality of the staining of the tissue sample. Also provided are a kit containing the microscope slide and a method of making and a method of using the microscope slide.Type: ApplicationFiled: March 20, 2014Publication date: September 22, 2016Inventors: Rui CHEN, Zhengyu PANG, Colin Craig MCCULLOCH, Michael LAZARE, Robert John FILKINS, Fiona GINTY
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Publication number: 20150226743Abstract: A method of analyzing a biological sample suspected of having classic Hodgkin lymphoma, comprising (1) detecting, in a single sample, for the expression of at least two biomarkers selected from CD30, CD15, CD20, CD45, CD3, Pax-5, CD79A, BOB1 and OCT-2; and (b) analyzing the sample based on the presence, absence and/or expression level of the at least two biomarkers. Also provided is a method wherein all the nine biomarkers are analyzed on a single sample. Further provided are method for diagnosing classical Hodgkin lymphoma, as well as system and kit that comprise the means for executing the novel methods.Type: ApplicationFiled: May 30, 2013Publication date: August 13, 2015Applicant: CLARIENT DIAGNOSTICS SERVICES, INC.Inventors: Lawrence M. Weiss, Rodney A. Beck, Lakshmi Sireesha Kaanumalle, Antti E. Seppo, David Lavan Henderson, Alex David Corwin, Kevin Bernard Kenny, Colin Craig Mcculloch, Fiona Ginty, Alexanderr G. Bordwell, Michael S. Lazare, Denise A. Hollman-Hewgley
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Publication number: 20150133321Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a distribution, location, and type of a plurality of the characterized cells.Type: ApplicationFiled: November 13, 2013Publication date: May 14, 2015Applicant: General Electric CompanyInventors: Srabani Bhaumik, Michael John Gerdes, Zhengyu Pang, Fiona Ginty, Christopher James Sevinsky, JR., Qing Li, Alberto Santamaria-Pang, Yunxia Sui, Keyur Hemantkumar Desai
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Publication number: 20150105283Abstract: A method for providing a composite image of a single biological sample from a patient suspected of having classical Hodgkin lymphoma, comprising the steps of generating a first image of the biological sample including the presence, absence and/or expression level of a first biomarker, generating a second image of the biological sample including the presence, absence and/or expression level of a second biomarker, and generating a composite image that provides the relative location or expression of both biomarkers. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the biomarkers of interest from the composite image. Further provided are method for diagnosing classical Hodgkin lymphoma, as well as system and kit that comprise the means for executing the novel methods.Type: ApplicationFiled: May 30, 2013Publication date: April 16, 2015Applicant: CLARIENT DIAGNOSTICS SERVICES, INC.Inventors: Lawrence M. Weiss, Rodney A. Beck, Lakshmi Sireesha Kaanumalle, Antti E. Seppo, David Lavan Henderson, Alex David Corwin, Kevin Bernard Kenny, Colin Craig McCulloch, Fiona Ginty, Alexanderr G. Bordwell, Michael S. Lazare, Denise A. Hollman-Hewgley