Abstract: An intragastric device includes an elongated member having a proximal end and a distal end and an anchor connected to the elongated member. The anchor includes a stem, a first arch and a second arch, and a curvilinear element. The stem includes a proximal end and a distal end. The distal end of the stem is attached to the proximal end of the elongated member. Each arch has first and second ends and a proximal peak therebetween. The first end of each arch is attached to the proximal end of the stem, and the second end of each arch extends radially away from the stem. The curvilinear element connects the second end of the first arch to the second end of the second arch.

Abstract: A system for delivering an endolumenal device through an endoscope includes a delivery tool and an adaptor. The delivery tool has an elongate tube configured to hold a portion of the endolumenal device therein and a first connecting feature on a distal end of the elongate tube. The adaptor is configured to attach to a handle of the endoscope. The adaptor includes a channel therethrough and a second connecting feature configured to mate with the first connecting feature of the delivery tool. The elongate tube of the delivery tool is configured to align with the channel of the adaptor when the first and second connecting features are mated.

Abstract: A system for delivering an endolumenal device through an endoscope includes a delivery tool and an adaptor. The delivery tool has an elongate tube configured to hold a portion of the endolumenal device therein and a first connecting feature on a distal end of the elongate tube. The adaptor is configured to attach to a handle of the endoscope. The adaptor includes a channel therethrough and a second connecting feature configured to mate with the first connecting feature of the delivery tool. The elongate tube of the delivery tool is configured to align with the channel of the adaptor when the first and second connecting features are mated.

Abstract: An intragastric device includes an elongated member having a proximal end and a distal end and an anchor connected to the elongated member. The anchor includes a stem, a first arch and a second arch, and a curvilinear element. The stem includes a proximal end and a distal end. The distal end of the stem is attached to the proximal end of the elongated member. Each arch has first and second ends and a proximal peak therebetween. The first end of each arch is attached to the proximal end of the stem, and the second end of each arch extends radially away from the stem. The curvilinear element connects the second end of the first arch to the second end of the second arch.

Abstract: Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.

Abstract: Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.

Abstract: Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.

Abstract: An intragastric device includes an elongated member having a proximal end and a distal end and an anchor connected to the elongated member. The anchor includes a stem, a first arch and a second arch, and a curvilinear element. The stem includes a proximal end and a distal end. The distal end of the stem is attached to the proximal end of the elongated member. Each arch has first and second ends and a proximal peak therebetween. The first end of each arch is attached to the proximal end of the stem, and the second end of each arch extends radially away from the stem. The curvilinear element connects the second end of the first arch to the second end of the second arch.

Abstract: Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.

Abstract: An endovascular navigation system and method are disclosed. The endovascular navigation system includes an elongate flexible member configured to access the venous vasculature of a patient, a processor, and a display. The elongate flexible member includes an endovascular electrogram lead disposed at a distal end of the elongate flexible member and configured to sense an endovascular electrogram signal of the venous vasculature of the patient, and a first wireless interface configured to wirelessly transmit the endovascular electrogram signal to the processor. The processor includes a second wireless interface configured to wirelessly receive the endovascular electrogram signal from the elongate flexible member. The processor is configured to determine that the position of the distal end of the elongate flexible member is within a predetermined structure within the venous vasculature of the patient.

Abstract: An endovascular navigation system and method are disclosed. The endovascular navigation system includes an elongate flexible member, a processor, and a display. The elongate flexible member includes an endovascular electrogram lead disposed at its distal end for sensing an endovascular electrogram signal of the venous vasculature of the patient, and a first wireless interface configured to wirelessly transmit the endovascular electrogram signal to the processor. The processor includes a second wireless interface configured to wirelessly receive the endovascular electrogram signal from the elongate flexible member. The processor is configured to determine that the position of the distal end of the elongate flexible member is within a predetermined structure within the venous vasculature of the patient. The display is configured to display a visual indication that the distal end of the elongate flexible member is within the predetermined structure.

Abstract: Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.

Abstract: An endovascular navigation system and method are disclosed. The endovascular navigation system includes an elongate flexible member, a endovascular electrogram lead disposed at a distal end of the elongate flexible member and configured to sense an endovascular electrogram signal, a processor and an output device. The processor is configured to receive the endovascular electrogram signal, to determine a peak amplitude of a P-wave in the endovascular electrogram signal, and to determine that the position of the distal end of the elongate flexible member is within a predetermined structure within the venous vasculature of the patient. The output device is configured to display a visual indication that the distal end of the elongate flexible member is within the predetermined structure within the venous vasculature of the patient, where the visual indication is different from the endovascular electrogram signal of the venous vasculature of the patient.

Abstract: An endovascular navigation system and method are disclosed. The endovascular navigation system includes an elongate flexible member, a endovascular electrogram lead disposed at a distal end of the elongate flexible member and configured to sense an endovascular electrogram signal, a processor and an output device. The processor is configured to receive the endovascular electrogram signal, to determine a peak amplitude of a P-wave in the endovascular electrogram signal, and to determine that the position of the distal end of the elongate flexible member is within a predetermined structure within the venous vasculature of the patient. The output device is configured to display a visual indication that the distal end of the elongate flexible member is within the predetermined structure within the venous vasculature of the patient, where the visual indication is different from the endovascular electrogram signal of the venous vasculature of the patient.

Abstract: Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.

Abstract: Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.

Abstract: The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.

Abstract: An intragastric device includes an elongated member having a proximal end and a distal end and an anchor connected to the elongated member. The anchor includes a stem, a first arch and a second arch, and a curvilinear element. The stem includes a proximal end and a distal end. The distal end of the stem is attached to the proximal end of the elongated member. Each arch has first and second ends and a proximal peak therebetween. The first end of each arch is attached to the proximal end of the stem, and the second end of each arch extends radially away from the stem. The curvilinear element connects the second end of the first arch to the second end of the second arch.

Abstract: Devices and methods described include a flow reduction device adapted and configured for use within the duodenum of a mammal having a spine, a first atraumatic feature, a second atraumatic feature, and a flow reduction element having a proximal end, a distal end, an interior portion, an exterior portion and a variable porosity between the proximal end and the distal end. One aspect of the device includes a spine having a proximal end and a distal end, an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine, and a flow reduction element positioned along the spine and having a variable porosity along its length.

Abstract: A system for delivering an endolumenal device through an endoscope includes a delivery tool and an adaptor. The delivery tool has an elongate tube configured to hold a portion of the endolumenal device therein and a first connecting feature on a distal end of the elongate tube. The adaptor is configured to attach to a handle of the endoscope. The adaptor includes a channel therethrough and a second connecting feature configured to mate with the first connecting feature of the delivery tool. The elongate tube of the delivery tool is configured to align with the channel of the adaptor when the first and second connecting features are mated.