Patents by Inventor Fiona Suzanne Adair

Fiona Suzanne Adair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • De-immunized streptokinase
    Patent number: 7465572
    Abstract: A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells (“T-cell epitopes”) of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: December 16, 2008
    Assignee: Merck Patent GmbH
    Inventors: Francis Joseph Carr, Fiona Suzanne Adair, Anita Anne Hamilton, Graham Carter
  • Method for rendering streptokinase less immunogenic to a human
    Patent number: 7125689
    Abstract: Protein, or parts of proteins, may be rendered non-immunogenic, or less immunogenic, to a given species by identifying in their amino acid sequences one or more potential epitopes for T-cells of the given species and modifying the amino acid sequence to eliminate at least one of the T-cell epitopes. This eliminates or reduces the immunogenicity of the protein when exposed to the immune system of the given species. Monoclonal antibodies and other immunoglobulin-like molecules can particularly benefit from being de-immunised in this way: for example, mouse-derived immunoglobulins can be de-immunised for human therapeutic use.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: October 24, 2006
    Assignee: Biovation Limited
    Inventors: Francis Joseph Carr, Fiona Suzanne Adair, Anita Anne Hamilton, Graham Carter
  • Methods for protein screening
    Patent number: 6927025
    Abstract: This invention provides methods of protein/polypeptide screening based on the provision of libraries of individual proteins/polypeptides, which in turn can be screened for a number of activities, including cell binding and biological activity. Methods for recovering genes encoding such proteins/polypeptides are also provided.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 9, 2005
    Assignee: Biovation Limited
    Inventors: Francis Joseph Carr, Graham Carter, Anita Anne Hamilton, Fiona Suzanne Adair, Stephen Williams
  • Method for the production of non-immunogenic proteins
    Publication number: 20030153043
    Abstract: Protein, or parts of proteins, may be rendered non-immunogenic, or less immunogenic, to a given species by identifying in their amino acid sequences one or more potential epitopes for T-cells of the given species and modifying the amino acid sequence to eliminate at least one of the T-cell epitopes. This eliminates or reduces the immunogenicity of the protein when exposed to the immune system of the given species. Monoclonal antibodies and other immunoglobulin-like molecules can particularly benefit from being de-immunised in this way: for example, mouse-derived immunoglobulins can be de-immunised for human therapeutic use.
    Type: Application
    Filed: November 20, 2002
    Publication date: August 14, 2003
    Applicant: Biovation Limited
    Inventors: Francis Joseph Carr, Fiona Suzanne Adair, Anita Anne Hamilton, Graham Carter