Patents by Inventor Fiorenzo Omenetto

Fiorenzo Omenetto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200108183
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Application
    Filed: May 9, 2019
    Publication date: April 9, 2020
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Patent number: 10562024
    Abstract: The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: February 18, 2020
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David L. Kaplan, Hu Tao
  • Patent number: 10493179
    Abstract: The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be shaped into 3-dimensional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: December 3, 2019
    Assignee: Trustees of Tufts College
    Inventors: Shenzhou Lu, Xiaoqin Wang, Fiorenzo Omenetto, David L. Kaplan
  • Publication number: 20190343137
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Application
    Filed: March 21, 2019
    Publication date: November 14, 2019
    Inventors: Fiorenzo Omenetto, David Kaplan, Benedetto Marelli, Mark Brenckle
  • Publication number: 20190255181
    Abstract: The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
    Type: Application
    Filed: July 17, 2018
    Publication date: August 22, 2019
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Gary G. Leisk, Tim Jia-Ching Lo, Benjamin Partlow, Rosario Friedman
  • Patent number: 10335519
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: July 2, 2019
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Patent number: 10280204
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: May 7, 2019
    Assignee: Tufts University
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 10271561
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: April 30, 2019
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David Kaplan, Benedetto Marelli, Mark Brenckle
  • Patent number: 10126467
    Abstract: The present invention provides silk photonic crystals that can be used to enhance light-induced effects. Also disclosed are biocompatible, functionalized, all-protein inverse opals and related methods.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: November 13, 2018
    Assignee: TUFTS UNIVERSITY
    Inventors: Fiorenzo Omenetto, David Kaplan, Sunghwan Kim
  • Patent number: 10040834
    Abstract: A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: August 7, 2018
    Assignee: TUFTS UNIVERSITY
    Inventors: Fiorenzo Omenetto, David L. Kaplan, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 10035920
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: July 31, 2018
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Patent number: 10034945
    Abstract: The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 31, 2018
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Gary G. Leisk, Tim Jia-Ching Lo, Benjamin Partlow, Rosario Friedman
  • Patent number: 9986924
    Abstract: Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: June 5, 2018
    Assignees: The Board of Trustees of the University of Illinois, Northwestern University, Trustees of Tufts College, The Trustees of the University of Pennsylvania
    Inventors: John A. Rogers, Dae-Hyeong Kim, Fiorenzo Omenetto, David L. Kaplan, Brian Litt, Jonathan Viventi, Yonggang Huang, Jason Amsden
  • Patent number: 9969134
    Abstract: A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: May 15, 2018
    Assignee: Trustees of Tufts College
    Inventors: David Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 9802374
    Abstract: A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: October 31, 2017
    Assignee: TUFTS UNIVERSITY
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb, Irene Georgakoudi
  • Patent number: 9761789
    Abstract: The invention relates to methods and compositions for preparing silk-based piezoelectric materials and methods for increasing piezoelectricity in silk matrices.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: September 12, 2017
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David Kaplan, Tuna Yucel
  • Publication number: 20170218228
    Abstract: 3D printing of biopolymer-based inks provides for manufacturing a broad range of products with desirable properties. A print nozzle may be charged to form a cone-shaped ink droplet to result in increased resolution, more reliable contact with irregular surfaces, and a mechanism to control contacting the ink to the print surface.
    Type: Application
    Filed: July 30, 2015
    Publication date: August 3, 2017
    Applicant: Tufts University
    Inventors: Rodrigo R. JOSE, Fiorenzo OMENETTO, David KAPLAN
  • Publication number: 20170156356
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Application
    Filed: March 6, 2015
    Publication date: June 8, 2017
    Inventors: Fiorenzo OMENETTO, David KAPLAN, Benedetto MARELLI, Mark BRENCKLE
  • Patent number: 9655993
    Abstract: This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: May 23, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Jeffrey K. Marchant, Noorjahan Panjwani, Brian Lawrence
  • Patent number: 9603243
    Abstract: The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or biophotonic devices, biosensors, surveillance devices, invisible cloaks, electromagnetic concentrators or antennas.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: March 21, 2017
    Assignees: TUFTS UNIVERSITY, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: David Kaplan, Fiorenzo Omenetto, Hu Tao, Richard Averitt, Andrew Strikwerda, Xin Zhang, Konstantinos Tsioris