Patents by Inventor Flavio Leoni

Flavio Leoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-XYLAN SULFATE POLYCLONAL ANTISERUM AND USE THEREOF IN ELISA METHODS
    Publication number: 20210253674
    Abstract: The object of the present invention is an anti-xylan sulfate antiserum having an antibody titre of between 1/10000 and 1/15000, and obtainable using a specific immunization method, and use thereof in one or more ELISA methods for determining xylan sulfate levels in biological fluids.
    Type: Application
    Filed: July 1, 2019
    Publication date: August 19, 2021
    Applicant: Chemi S.P.A.
    Inventors: Flavio Leoni, Giuliana Porro
  • Use of hydroxamic acid derivatives for the preparation of anti-tumour medicaments
    Patent number: 8227515
    Abstract: Method of treating a tumor in a patient in need thereof by administering to the patient an effective amount of 4-[6-(diethylaminomethyl)naphth-2-ylmethyloxycarbamoyl]benzohydrozamic acid.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: July 24, 2012
    Assignee: Italfarmaco S.p.A.
    Inventors: Flavio Leoni, Paolo Mascagni
  • Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds
    Patent number: 7157099
    Abstract: Stable, biologically compatible pharmaceutical compositions in the form of water-in-oil microemulsions (w/o), for the sustained release by parenteral administration of active ingredients which are hydrophilic or are made hydrophilic by suitable derivatization, a process for the preparation of said microemulsions and the use thereof.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: January 2, 2007
    Assignee: Italfarmaco S.p.A.
    Inventors: Francesco Autuori, Carlo Bianchini, Giuseppe Bottoni, Flavio Leoni, Paolo Mascagni, Valmen Monzani, Oreste Piccolo
  • Use of hydroxamic acid derivatives for the preparation of anti-tumour medicaments
    Publication number: 20060063800
    Abstract: The present invention relates to the use of hydroxamic acid derivatives containing an amidobenzoic moiety for the preparation of anti-tumour medicaments.
    Type: Application
    Filed: December 10, 2003
    Publication date: March 23, 2006
    Inventors: Flavio Leoni, Paolo Mascagni
  • Histone deacetylase enzyme-inhibiting derivatives of hydroxamic acid as new cytokine synthesis-inhibiting anti-inflammatory drugs
    Publication number: 20040157930
    Abstract: The use of derivatives of hydroxamic acid having histone deacetylase enzyme-inhibiting activity for the preparation of anti-inflammatory medicaments is disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: August 12, 2004
    Inventors: Paolo Mascagni, Flavio Leoni, Giulia Porro, Paolo Pagani, Giancarlo Dona, Pietro Pozzi, Charles Dinarello, Giamila Fantuzzi, Britta Siegmund, Leonid Reznikov, Philip Bufler, Soo Hyun Kim, Benjamin Pomeranz
  • Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds
    Publication number: 20030171299
    Abstract: Stable, biologically compatible pharmaceutical compositions in the form of water-in-oil microemulsions (w/o), for the sustained release by parenteral administration of active ingredients which are hydrophilic or are made hydrophilic by suitable derivatization, a process for the preparation of said microemulsions and the use thereof.
    Type: Application
    Filed: November 6, 2002
    Publication date: September 11, 2003
    Inventors: Francesco Autuori, Carlo Bianchini, Giuseppe Bottoni, Flavio Leoni, Paolo Mascagni, Valmen Monzani, Oreste Piccolo
  • Oligopeptides derived from C-reactive protein fragments
    Patent number: 6342481
    Abstract: The present invention relates to oligopeptide derived from fragments of the C-reactive protein (CRP), and to their use in the therapy of cardiovascular and inflammatory diseases.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: January 29, 2002
    Assignee: Italfarmaco S.p.A.
    Inventors: Flavio Leoni, Silvio Agozzino, Paolo Mascagni
  • Heparin derivatives having antimetastatic activity
    Patent number: 6130210
    Abstract: Heparin derivatives are disclosed that may be used to inhibit formation of metastases. One series of heparin derivatives of the invention are N-acylated with monocarboxylic acids or dicarboxylic acids and have molecular weights from about 1000 Daltons to about 30,000 Daltons. Another series of heparin derivatives of the invention have average molecular weights ranging from about 1000 to 3000 daltons, and are optionally N-acylated with residues from aliphatic monocarboxylic or dicarboxylic acids.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: October 10, 2000
    Assignee: Italfarmaco S.p.A.
    Inventors: Patrizia Caretto, Teresa Sciumbata, Flavio Leoni, Gianni Gromo
  • Oligopeptides derived from C-reactive protein fragments
    Patent number: 6057295
    Abstract: Oligopeptides derived from fragments of C-reactive proteins and their use as immunomodulating agents in the therapy of cardiovascular and inflammatory diseases.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: May 2, 2000
    Assignee: Italfarmaco S.p.A.
    Inventors: Patrizia Caretto, Flavio Leoni, Fabrizio Marcucci, Gianni Gromo, Paolo Mascagni, Massimo Pinori, Silvana Cappelletti
  • Compounds with anti-inflammatory and immunosuppressive activities
    Patent number: 6034096
    Abstract: The present invention provides medicinal compounds that are characterized by a cyclic moiety (A) linked through a carboxamido group (more specifically, a carbamate group or a urea group) to another cyclic moiety (B) which is in turn linked to another, N-substituted carboxamido group. These compounds can be used an anti-inflammatory and immunosuppressive agents, as demonstrated by their inhibition of the production of IL-1.beta. in vitro and TNF.alpha. in vivo.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: March 7, 2000
    Assignee: Italfarmaco S.p.A.
    Inventors: Giorgio Bertolini, Mauro Biffi, Flavio Leoni, Jacques Mizrahi, Gianfranco Pavich, Paolo Mascagni
  • Analogues of the active metabolite of leflunomide
    Patent number: 5905090
    Abstract: Analogues of the active metabolite of leflunomide, and to the use thereof as immunosuppressive and/or antinflammatory agents.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: May 18, 1999
    Assignee: Italfarmaco S.p.A.
    Inventors: Giorgio Bertolini, Mauro Biffi, Flavio Leoni, Maria Letizia Marchetti, Jacques Mizrahi, Flavio Somenzi, Paolo Mascagni
  • Heparin derivatives having antimetastatic activity
    Patent number: 5763421
    Abstract: Heparin derivatives are disclosed which may be used to inhibit formation of metastases. The heparin derivatives of the invention are N-acylated with mono- or dicarboxylic acids, have a molecular weight from about 1,000 to about 30,000 Daltons, and have at least one unit of an open D- or L-iduronic acid.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: June 9, 1998
    Assignee: Italfarmaco S.p.A.
    Inventors: Patrizia Caretto, Teresa Sciumbata, Flavio Leoni, Gianni Gromo
  • Partially modified and retro-inverted tetrapeptides analogues of C-reactive protein fragments
    Patent number: 5578575
    Abstract: A method for treating septic shock by administering a retroinverted tetrapeptides of formula I ##STR1## wherein R is a hydrogen atom or the side-chain of threonine; R.sub.1 is the side-chain of arginine, leucine or glutamine; and R.sub.2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R.sub.1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof.
    Type: Grant
    Filed: February 28, 1996
    Date of Patent: November 26, 1996
    Assignee: Italfarmaco S.P.A.
    Inventors: Antonio S. Verdini, Massimo Pinori, Silvana Cappelletti, Laura Gazerro, Flavio Leoni
  • Partially modified and retro-inverted tetrapeptides analogues of C-reactive protein fragments
    Patent number: 5521159
    Abstract: Retro-inverted tetrapeptides of formula I ##STR1## wherein R is a hydrogen atom or the side-chain of threonine; R.sub.1 is the side-chain of arginine, leucine or glutamine; and R.sub.2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R.sub.1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof. These compounds are useful as immuno-stimulating agents.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: May 28, 1996
    Assignee: Italfarmaco S.p.A.
    Inventors: Antonio S. Verdini, Massimo Pinori, Silvana Cappelletti, Laura Gazerro, Flavio Leoni