Patents by Inventor Flavio Toma

Flavio Toma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16
    Patent number: 5677281
    Abstract: The invention relates to the use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16.These peptide derivatives are in accordance with the formula: ##STR1## in which R.sup.1 is an optionally substituted aralkyl group, R.sup.2 is Pro, Hyp, thiazolidine or dehydroproline, R.sup.3 is H or an alkyl radical, R.sup.4 is an alkyl group or the side chain of an amino acid, R.sup.5 and R.sup.6 can be H, NH.sub.4 + or metals and R.sup.7 is H or CH.sub.3.N-(phenylethylphosphonyl)-Gly-Pro-aminohexanoic acid and N-(phenylethyl phosphonyl)-Ala-Pro-aminohexanoic acid are examples of effective derivatives.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: October 14, 1997
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Vincent Dive, Flavio Toma, Athanasios Yiotakis
  • Derivatives of peptides usable as inhibitors of bacterial collagenases
    Patent number: 5500414
    Abstract: The invention relates to novel peptide derivatives usable as inhibitors of bacterial collagenases.These derivatives comply with the formula: ##STR1## in which R.sup.1 is a hydrogen atom, a blocking group or a radical derived from an amino acid or a peptide optionally protected by a blocking group, R.sup.2 is the side chain of an .alpha.-amino acid, R.sup.3 is H, a metal, an alkyl or benzyl group, R.sup.4 is the derivative of proline, hydroxyproline, thiazolidine or dehydroproline, R.sup.5 is H or an alkyl, R.sup.6 is the side of an amino acid and R.sup.7 is OR.sup.8 with R.sup.8 being H, a metal, alkyl or benzyl, or in which R.sup.1 and R.sup.7 together form a divalent radical derived from an amino acid or a peptide.The derivatives in which R.sup.3 is a metal or hydrogen are usable as inhibitors of bacterial collagenases.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: March 19, 1996
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Vincent Dive, Flavio Toma, Athanasios Yiotakis
  • Phosphonic peptide inhibitors of bacterial collagenases
    Patent number: 5389612
    Abstract: The invention relates to novel derivatives of peptides usable as inhibitors of bacterial collagenases.These derivatives comply with the formula: ##STR1## in which R.sup.1 is an optionally substituted aryl or aralkyl group or the group ##STR2## with R.sup.6 being the side chain of an .alpha.-amino acid and R.sup.7 R.sup.8 a protective group or a radical derived from an amino acid or a protected peptide, R.sup.2 is derived from proline, hydroxyproline, thiazolidine or dehydroproline, R.sup.3 is H or an alkyl, and R.sup.4 is the side chain of an amino acid and R.sup.5 and R'.sup.5 are H, a metal, an alkyl or benzyl.The derivatives in which R'.sup.5 is a metal or hydrogen can be used as inhibitors of bacterial collagenases.
    Type: Grant
    Filed: September 23, 1992
    Date of Patent: February 14, 1995
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Vincent Dive, Flavio Toma, Athanasios Yiotakis