Patents by Inventor Flemming Elmelund Nielsen

Flemming Elmelund Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5,8-DIMETHYL-2-[2-(1-METHYL-4-PHENYL-1H-IMIDAZOL-2-YL)-ETHYL]-[1,2,4]TRIAZOLO[1,5-A]PYRAZINE HEMIADIPATE
    Publication number: 20200140446
    Abstract: The present invention relates to 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate, which is non-hygroscopic. The present invention also relates to pharmaceutical compositions comprising 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate, as well as the use of 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate in therapy. The 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate being depicted below.
    Type: Application
    Filed: November 5, 2019
    Publication date: May 7, 2020
    Applicant: H. Lundbeck A/S
    Inventors: Anette Frost Jensen, Lars Ole Lyngsø, Flemming Elmelund Nielsen
  • 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes
    Patent number: 8022066
    Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: September 20, 2011
    Assignee: High Point Pharmaceuticals, LLC
    Inventors: Anders Klarskov Petersen, Preben Houlberg Olesen, Lise Brown Christiansen, Holger Claus Hansen, Flemming Elmelund Nielsen
  • Haloalkylsulfone substituted compounds useful for treating obesity and diabetes
    Patent number: 7939690
    Abstract: The present invention relates to novel compounds of formula [I], wherein R1 represents heteroaryl, at least one substituent among R5, R6 and R7 represent —SR12, —S(O)R12 or —S(O)2R12 and the remaining substituents are as defined in the claims, that act as chemical uncouplers. Compounds of the invention are useful inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases associated therewith.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 10, 2011
    Assignee: High Point Pharmaceuticals, LLC
    Inventors: Anders Klarskov Petersen, Preben Houlberg Olesen, Lise Brown Christiansen, Flemming Elmelund Nielsen
  • 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes
    Patent number: 7915299
    Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: March 29, 2011
    Assignee: High Point Pharmaceuticals, LLC
    Inventors: Anders Klarskov Petersen, Preben Houlberg Olesen, Lise Brown Christiansen, Holger Claus Hansen, Flemming Elmelund Nielsen
  • 2- ( 2 -HYDROXYPHENYL) -QUINAZOLIN-4-ONES USEFUL FOR TREATING OBESITY AND DIABETES
    Publication number: 20100249161
    Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
    Type: Application
    Filed: November 15, 2007
    Publication date: September 30, 2010
    Inventors: Anders Klarskov Petersen, Preben Houlberg Olesen, Lise Brown Christiansen, Holger Claus Hansen, Flemming Elmelund Nielsen
  • HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES
    Publication number: 20100113536
    Abstract: The present invention relates to novel compounds of formula [I], wherein R1 represents heteroaryl, at least one substituent among R5, R6 and R7 represent —SR12, —S(O)R12 or —S(O)2R12 and the remaining substituents are as defined in the claims, that act as chemical uncouplers. Compounds of the invention are useful inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases associated therewith.
    Type: Application
    Filed: November 15, 2007
    Publication date: May 6, 2010
    Inventors: Anders Klarskov Petersen, Preben Houlberg Olesen, Lise Brown Christiansen, Flemming Elmelund Nielsen
  • NOVEL 2-(2-HYDROXYPHENYL)BENZIMlDAZOLES USEFUL FOR TREATING OBESITY AND DIABETES
    Publication number: 20100063122
    Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
    Type: Application
    Filed: November 15, 2007
    Publication date: March 11, 2010
    Inventors: Anders Klarskov Peterson, Preben Houlberg Olesen, Lise Brown Christiansen, Holger Claus Hansen, Flemming Elmelund Nielsen
  • HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES
    Publication number: 20100041657
    Abstract: The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
    Type: Application
    Filed: May 11, 2006
    Publication date: February 18, 2010
    Applicant: NOVO NORDICK A/S
    Inventors: Preben Houlberg Olesen, Holger Claus Hansen, Lise Brown Christiansen, Flemming Elmelund Nielsen, Anders Klarskov Petersen
  • NOVEL 2-(2-HYDROXYPHENYL) BENZOTHIADIAZINES USEFUL FOR TREATING OBESITY AND DIABETES
    Publication number: 20090325941
    Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
    Type: Application
    Filed: November 15, 2007
    Publication date: December 31, 2009
    Inventors: Anders Klarskov Petersen, Preben Houlberg Olesen, Lise Brown Christiansen, Holger Claus Hansen, Flemming Elmelund Nielsen
  • Novel Haloalkoxy-Substituted Salicylic Anilides
    Publication number: 20090062396
    Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or disorders associated therewith.
    Type: Application
    Filed: May 23, 2006
    Publication date: March 5, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Preben Houlberg Olesen, Holger Claus Hansen, Lise Brown Christiansen, Anders Klarskov Petersen, Flemming Elmelund Nielsen, Birgit Sehested Hansen
  • Novel Trifluoromethoxy-Substituted Aryl Anilides
    Publication number: 20080234381
    Abstract: The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or disorders associated therewith.
    Type: Application
    Filed: May 23, 2006
    Publication date: September 25, 2008
    Applicant: Novo Nordisk A/S
    Inventors: Preben Houlberg Olesen, Holger Claus Hansen, Lise Brown Christiansen, Anders Klarskov Petersen, Flemming Elmelund Nielsen, Birgit Sehested Hansen
  • Novel process
    Publication number: 20040010142
    Abstract: The present invention relates to a novel processes for preparing pharmaceutically active compounds of formula (I): 1
    Type: Application
    Filed: June 17, 2003
    Publication date: January 15, 2004
    Inventors: Flemming Elmelund Nielsen, Hanne T. Korno, Kaare G. Rasmussen
  • Novel process
    Publication number: 20020119969
    Abstract: The present invention relates to a novel processes for preparing pharmaceutically active fused 1,2,4-thiadiazine derivatives of general formula (I) as defined in the description and intermediates therefore.
    Type: Application
    Filed: August 8, 2001
    Publication date: August 29, 2002
    Inventors: Soren Ebdrup, Flemming Elmelund Nielsen
  • Fused 1,2,4- thiadiazine derivatives, their preparation and use
    Publication number: 20020086861
    Abstract: The present invention relates to 4H-thieno[3,2-e]-1,2,4-thiadiazine derivatives of the general formula: 1
    Type: Application
    Filed: December 7, 2001
    Publication date: July 4, 2002
    Inventors: John Bondo Hansen, Flemming Elmelund Nielsen
  • Fused 1,2,4-thiadiazine derivatives, their preparation and use
    Patent number: 6329367
    Abstract: The present invention relates to 4H-thieno[3,2-e]-1,2,4-thiadiazine derivatives of the general formula: wherein X, Y, R1, R2 and R3 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: December 11, 2001
    Assignee: Novo Nordisk A/S
    Inventors: John Bondo Hansen, Flemming Elmelund Nielsen
  • 1,2,4-benzothiadiazine derivatives, their preparation and use
    Patent number: 6242443
    Abstract: 1,2,4-Benzothiadiazine derivatives represented by formula wherein D, R1, R2, R3, R4, R5, R12, R13, R14, R15 are defined in the description, composition thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: June 5, 2001
    Assignee: Novo Nordisk AIS
    Inventors: Bernard Pirotte, Philippe Lebrun, Pascal De Tullio, Fabian Somers, Jacques Delarge, John Bondo Hansen, Flemming Elmelund Nielsen, Holger Claus Hansen, John Patrick Mogensen, Tina Møller-Tagmose
  • Fused 1,2,4-thiadiazine derivatives, their preparation and use
    Patent number: 6225310
    Abstract: 1,2,4-Thiadiazine and 1,4-thiazine derivates represented by formula (I): wherein A, B, D, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: May 1, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Flemming Elmelund Nielsen, John Bondo Hansen, Holger Claus Hansen, Tina Møller Tagmose, John Patrick Mogensen
  • [1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use
    Patent number: 6001832
    Abstract: The present invention relates to [1,2,4]triazolo[4,3-a]quinoxalinone compounds of the formula ##STR1## wherein R.sup.1 is POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R.sup.7 is trifluoromethyl, and R.sup.6, R.sup.8 and R.sup.9 independently are piperidino, piperazinyl, morpholino, or thiomorpholino, which rings are optionally substituted with one or more of phenyl or C.sub.1-6 -alkyl and phenyl optionally being substituted with C.sub.1-6 -alkoxy; and pharmaceutically acceptable salts thereof. The compounds of the present invention are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: December 14, 1999
    Assignee: Novo Nordiskals
    Inventor: Flemming Elmelund Nielsen
  • Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
    Patent number: 5889002
    Abstract: 1,2,4-Thiadiazine and 1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: March 30, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Flemming Elmelund Nielsen, Holger Claus Hansen, John Bondo Hansen, Tina M.o slashed.ller Tagmose
  • Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives, their preparation and use
    Patent number: 5792764
    Abstract: Pyrido-1,2,4-thiadiazine and pyrido-1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, pulmonary system, the gastrointestinal system and the endocrinologic system.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: August 11, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Bernard Pirotte, Philippe Lebrun, Pascal De Tullio, Fabian Somers, Jacques Delarge, Holger Claus Hansen, Flemming Elmelund Nielsen, John Bondo Hansen