Patents by Inventor Flonia Levy-Adam

Flonia Levy-Adam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS
    Publication number: 20110104140
    Abstract: The present invention relates to inhibition of heparinoids anti-coagulation activity by a non-active form of a eukaryotic endoglycosidase or any fragment or peptide thereof comprising at least one heparin-binding domain. More particularly, the invention provides compositions and methods for the inhibition of heparinoids anti-coagulation activity and for the treatment of coagulation related pathologic clinical conditions, using a non-active form of mammalian heparanase or peptides thereof comprising at least one heparin-binding domain.
    Type: Application
    Filed: May 10, 2007
    Publication date: May 5, 2011
    Inventors: Israel Vlodavsky, Neta Ilan, Flonia Levy-Adam, Ben-Zion Katz
  • Substances directed against a specific sequence essential for heparanase catalytic activity and uses thereof as heparanase inhibitors
    Patent number: 7772187
    Abstract: An amino acid sequence derived from the N? terminus region of the 50 Kd subunit of heparanase, preferably, the sequence including amino acid residues Lys158-Asn171 of human heparanase and any functional fragments thereof. Compositions for the inhibition of heparanase glycosidase catalytic activity, having as an active ingredient an isolated and purified peptide as the amino acid sequence. An antibody directed to the sequence and compositions and uses thereof as heparanase inhibitor. The use of the amino acid sequence in a screening method for specific heparanase inhibitors. Compositions including the heparanase inhibitors and methods for the treatment of heparanase related disorders.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: August 10, 2010
    Assignees: Hadasit Medical Research Services and Development Company, Ltd., Rappaport Family Institute for Research in the Medical Sciences
    Inventors: Israel Vlodavsky, Neta Ilan, Flonia Levy-Adam
  • Substances directed against a specific sequence essential for heparanase catalytic activity and uses thereof as heparanase inhibitors
    Publication number: 20050169907
    Abstract: An amino acid sequence derived from the N? terminus region of the 50 Kd subunit of heparanase, preferably, the sequence including amino acid residues Lys158-Asn171 of human heparanase and any functional fragments thereof. Compositions for the inhibition of heparanase glycosidase catalytic activity, having as an active ingredient an isolated and purified peptide as the amino acid sequence. An antibody directed to the sequence and compositions and uses thereof as heparanase inhibitor. The use of the amino acid sequence in a screening method for specific heparanase inhibitors. Compositions including the heparanase inhibitors and methods for the treatment of heparanase related disorders.
    Type: Application
    Filed: July 28, 2004
    Publication date: August 4, 2005
    Applicant: HADASIT MEDICAL RESEARCH SERVICE AND DEVELOPMENT COMPANY LTD.
    Inventors: Israel Vlodavsky, Neta Ilan, Flonia Levy-Adam