Patents by Inventor Flor de María RAMÍREZ DE LA CRUZ

Flor de María RAMÍREZ DE LA CRUZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 177Lu-DOTA-HYNIC-iPSMA AS A THERAPEUTIC RADIOPHARMACEUTICAL TARGETING PROSTATE-SPECIFIC MEMBRANE ANTIGEN
    Publication number: 20210015949
    Abstract: The invention relates to a new lutetium-177 therapeutic radiopharmaceutical as an inhibitor of prostate-specific membran antigen (iPSMA), wherein 1,4,7,10-tetraazacyclododecane-N,N?,N?,N??-tetraacetic acid (DOTA) bonded to the heterocyclic molecule hydrazinonicotinamide (HYNIC), generates a rigid chemical structure that minimises the number of conformers and intramolecular hydrogen bonds, thereby producing a favourable spatial orientation of the active site (Lys(Nal)-NH—CO—NH-Glu) in the molecule, for biological recognition by the PSMA protein. The new 177Lu-DOTA-HYNIC-iPSMA radiopharmaceutical accumulates, with high affinity in vivo, in tumours that overexpress the PSMA protein, acting as a radiotherapeutic agent.
    Type: Application
    Filed: March 7, 2019
    Publication date: January 21, 2021
    Applicant: INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES
    Inventors: Guillermina FERRO FLORES, Blanca Elí OCAMPO GARCÍA, Myrna Alejandra LUNA GUTIÉRREZ, Clara Leticia SANTOS CUEVAS, Erika Patricia AZORÍN VEGA, Nallely Patricia JIMÉNEZ MANCILLA, Tania HERNÁNDEZ JIMÉNEZ, Flor de María RAMÍREZ DE LA CRUZ