Patents by Inventor Florence Bettsworth
Florence Bettsworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210405034Abstract: A bi-epitope compound of formula (I): in which (i) E1 and E2, which may be identical or different, each independently represent a peptide sequence comprising at least one epitope of an analyte, (ii) X and Y, which may be identical or different, each independently represent a linker arm, (iii) the carrier molecule is soluble, and (iv) Z represents an amino acid derivative that had a thiol function before the bonding thereof with the carrier molecule.Type: ApplicationFiled: September 16, 2021Publication date: December 30, 2021Applicant: BIOMERIEUXInventors: Florence BETTSWORTH, Sandrine BUSSERET, Catherine POTHION
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Patent number: 11193929Abstract: A bi-epitope compound of formula I: in which: E1 and E2, identical or different, each separately represents a peptide sequence including at least one epitope of an analyte; X and Y, identical or different, each separately represents a linking arm, the carrier molecule is soluble and Z represents an amino acid derivative bearing a thiol function prior to the bonding of same with the carrier molecule. The compound may be contained in a composition, used as a control or standard in an immunoassay and associated method, and/or provided in a kit for implementing an immunoassay.Type: GrantFiled: December 17, 2015Date of Patent: December 7, 2021Assignee: BIOMERIEUXInventors: Florence Bettsworth, Sandrine Busseret, Catherine Pothion
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Patent number: 11029312Abstract: An aqueous composition includes (i) glutamate dehydrogenase from a bacterium of the Clostridium genus, (ii) a stabilizing compound that is a carboxylic acid having a carbon-based chain of at least three carbon atoms and comprising at least two —COOH groups, or a salt thereof, and (iii) any of a monosaccharide polyol, disaccharide polyol, or polymeric macromolecule in addition to the glutamate dehydrogenase. A process for stabilizing the glutamate dehydrogenase in order to maintain antigenic properties of the glutamate dehydrogenase includes stabilizing the glutamate dehydrogenase in the aqueous composition and maintaining the antigenic properties of the glutamate dehydrogenase during storage of the aqueous composition.Type: GrantFiled: January 3, 2020Date of Patent: June 8, 2021Assignee: BIOMERIEUXInventors: Florence Bettsworth, Jérôme Martinez
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Patent number: 11009505Abstract: An immunoassay composition includes at least (i) an amphipol and (ii) a (meth)acrylate monomer-based amphoteric copolymer, some of said monomers including a phosphorylcholine group. The composition is useful in particular as a stabilizer and/or blocking agent.Type: GrantFiled: December 20, 2016Date of Patent: May 18, 2021Assignee: BIOMERIEUXInventors: Sandrine Busseret, Florence Bettsworth, Jérôme Martinez
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Publication number: 20200132690Abstract: An aqueous composition includes (i) glutamate dehydrogenase from a bacterium of the Clostridium genus, (ii) a stabilizing compound that is a carboxylic acid having a carbon-based chain of at least three carbon atoms and comprising at least two —COOH groups, or a salt thereof, and (iii) any of a monosaccharide polyol, disaccharide polyol, or polymeric macromolecule in addition to the glutamate dehydrogenase. A process for stabilizing the glutamate dehydrogenase in order to maintain antigenic properties of the glutamate dehydrogenase includes stabilizing the glutamate dehydrogenase in the aqueous composition and maintaining the antigenic properties of the glutamate dehydrogenase during storage of the aqueous composition.Type: ApplicationFiled: January 3, 2020Publication date: April 30, 2020Applicant: BIOMERIEUXInventors: Florence BETTSWORTH, Jérôme MARTINEZ
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Patent number: 10533999Abstract: A process for stabilizing glutamate dehydrogenase (GDH) from a bacterium of the Clostridium genus, in an aqueous solution, in order to maintain the antigenic properties thereof, includes the step of mixing the glutamate dehydrogenase and a stabilizing composition which is a carboxylic acid having a carbon-based chain of at least 3 carbon atoms and comprising at least 2 —COOH groups, or a salt thereof. GDH compositions thus stabilized and a method of detecting the presence of bacteria of the Clostridium genus are also disclosed.Type: GrantFiled: December 8, 2014Date of Patent: January 14, 2020Assignee: BIOMERIEUXInventors: Florence Bettsworth, Jérôme Martinez
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Publication number: 20190204308Abstract: An immunoassay composition includes at least (i) an amphipol and (ii) a (meth)acrylate monomer-based amphoteric copolymer, some of said monomers including a phosphorylcholine group. The composition is useful in particular as a stabilizer and/or blocking agent.Type: ApplicationFiled: December 20, 2016Publication date: July 4, 2019Applicant: BIOMERIEUXInventors: Sandrine BUSSERET, Florence BETTSWORTH, Jérôme MARTINEZ
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Publication number: 20170269070Abstract: A bi-epitope compound of formula I: in which: E1 and E2, identical or different, each separately represents a peptide sequence including at least one epitope of an analyte; X and Y, identical or different, each separately represents a linking arm, the carrier molecule is soluble and Z represents an amino acid derivative bearing a thiol function prior to the bonding of same with the carrier molecule. The compound may be contained in a composition, used as a control or standard in an immunoassay and associated method, and/or provided in a kit for implementing an immunoassay.Type: ApplicationFiled: December 17, 2015Publication date: September 21, 2017Applicant: BIOMERIEUXInventors: Florence BETTSWORTH, Sandrine BUSSERET, Catherine POTHION
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Patent number: 9606120Abstract: The invention relates to novel interfering peptides having peptide sequence S with between 7 and 12 amino acids, originating from the peptide sequence of an antigenic protein of a micro-organism M, the sequence S being aligned with a peptide sequence S? with between 7 and 12 amino acids originating from the peptide sequence of a target protein of a micro-organism M? that is different from the micro-organism M, provided that: sequences S and S? have at least 50% identity over their length of 7 to 12 amino acids and at least 4 identical or analogous contiguous amino acids; and their length is identical or they have 1 or 2 different amino acids distributed at one and/or the other end of the sequences. The invention also relates to a method for the in vitro immunoassay-based detection of the presence of a micro-organism M? or M in a biological sample.Type: GrantFiled: March 11, 2013Date of Patent: March 28, 2017Assignee: BIOMERIEUXInventors: Florence Bettsworth, Catherine Pothion, Béatrice Seigneres
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Publication number: 20160299140Abstract: A process for stabilizing glutamate dehydrogenase (GDH) from a bacterium of the Clostridium genus, in an aqueous solution, in order to maintain the antigenic properties thereof, includes the step of mixing the glutamate dehydrogenase and a stabilizing composition which is a carboxylic acid having a carbon-based chain of at least 3 carbon atoms and comprising at least 2 —COOH groups, or a salt thereof. GDH compositions thus stabilized and a method of detecting the presence of bacteria of the Clostridium genus are also disclosed.Type: ApplicationFiled: December 8, 2014Publication date: October 13, 2016Applicant: BIOMERIEUXInventors: Florence BETTSWORTH, Jérôme MARTINEZ
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Publication number: 20150024380Abstract: The invention relates to novel interfering peptides having peptide sequence S with between 7 and 12 amino acids, originating from the peptide sequence of an antigenic protein of a micro-organism M, the sequence S being aligned with a peptide sequence S? with between 7 and 12 amino acids originating from the peptide sequence of a target protein of a micro-organism M? that is different from the micro-organism M, provided that: sequences S and S? have at least 50% identity over their length of 7 to 12 amino acids and at least 4 identical or analogous contiguous amino acids; and their length is identical or they have 1 or 2 different amino acids distributed at one and/or the other end of the sequences. The invention also relates to a method for the in vitro immunoassay-based detection of the presence of a micro-organism M? or M in a biological sample.Type: ApplicationFiled: March 11, 2013Publication date: January 22, 2015Inventors: Florence Bettsworth, Catherine Pothion, Béatrice Seigneres