Patents by Inventor Florence F. Wagner

Florence F. Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS RELATED TO BICYCLO[2.2.1] HEPTANAMINE-CONTAINING COMPOUNDS
    Publication number: 20240116850
    Abstract: The present disclosure relates to compositions and methods related to bicyclo[2.2.1]heptanamine-containing compounds and salts thereof.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 11, 2024
    Inventors: Brian T. Chamberlain, Florence F. Wagner, Maria Alimova, Anna Greka
  • Compositions and methods related to di-substituted bicyclo[2.2.1] heptanamine-containing compounds
    Patent number: 11840495
    Abstract: The present disclosure relates to compositions and methods related to bicyclo[2.2.1] heptanamine-containing compounds and salts.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: December 12, 2023
    Assignees: The Broad Institute, Inc., Instituto Carlos Slim de la Salud, A.C., Brigham and Women's Hospital, Inc.
    Inventors: Brian T. Chamberlain, David Kornfilt, Florence F. Wagner, Maria Alimova, Anna Greka, Joseph Growney
  • SUBSTITUTED 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-b]INDOLES FOR TREATING BRAIN DISORDERS
    Publication number: 20230117791
    Abstract: The present invention provides azepino-indoles and other heterocycles and methods of using the compounds for treating brain disorders.
    Type: Application
    Filed: July 12, 2022
    Publication date: April 20, 2023
    Inventors: David E. OLSON, Florence F. Wagner
  • COMPOSITIONS AND METHODS RELATED TO DI-SUBSTITUTED BICYCLO[2.2.1] HEPTANAMINE-CONTAINING COMPOUNDS
    Publication number: 20220242815
    Abstract: The present disclosure relates to compositions and methods related to bicyclo[2.2.1] heptanamine-containing compounds and salts.
    Type: Application
    Filed: December 23, 2021
    Publication date: August 4, 2022
    Inventors: Brian T. Chamberlain, David Kornfilt, Florence F. Wagner, Maria Alimova, Anna Greka, Joseph Growney
  • Fluorescent substrates for determining lysine modifying enzyme activity
    Patent number: 10626438
    Abstract: The invention relates to a compound of Formula I: F1—X1-L1-X2—P1—X3-G1??(Formula I).
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: April 21, 2020
    Assignee: The Broad Institute, Inc.
    Inventors: Yan-Ling Zhang, Edward Holson, Florence F. Wagner
  • FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY
    Publication number: 20180155760
    Abstract: The invention relates to a compound of Formula I: F1—X1-L1-X2—P1—X3-G1 ??(Formula I).
    Type: Application
    Filed: December 5, 2017
    Publication date: June 7, 2018
    Inventors: Yan-Ling Zhang, Edward Holson, Florence F. Wagner
  • Fluorescent substrates for determining lysine modifying enzyme activity
    Patent number: 9856509
    Abstract: The invention relates to a compound of Formula I: F1—X1-L1-X2—P1—X3-G1??(Formula I).
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: January 2, 2018
    Assignee: The Broad Institute, Inc.
    Inventors: Yan-Ling Zhang, Edward Holson, Florence F. Wagner
  • Chemokine receptor modulators
    Patent number: 9314468
    Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and/or esters thereof. These compounds, and pharmaceutical composition comprising such compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: April 19, 2016
    Assignee: Altiris Therapeutics, Inc.
    Inventors: Michael P Clark, Florence F Wagner, Michael G Natchus, Brandon C Doroh, Tricia L Johnson, Yesim Altas Tahirovic, Lawrence Wilson, John M Wiseman, Jason W Skudlarek, Mark A Lockwood
  • Solid forms of tacedinaline
    Patent number: 9266822
    Abstract: Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Form B, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Form B, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 23, 2016
    Assignee: THE BROAD INSTITUTE, INC.
    Inventors: Edward Holson, Florence F. Wagner, G. Patrick Stahly
  • FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY
    Publication number: 20140335550
    Abstract: The invention relates to a compound of Formula I: F1-X1-L1-X2-P1-X3-G1??(Formula I).
    Type: Application
    Filed: May 1, 2014
    Publication date: November 13, 2014
    Applicant: The Broad Institute, Inc.
    Inventors: Yan-Ling Zhang, Edward Holson, Florence F. Wagner
  • NOVEL SOLID FORMS OF TACEDINALINE
    Publication number: 20140275268
    Abstract: Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Form B, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Form B, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: Edward Holson, Florence F. Wagner, G. Patrick Stahly
  • Methods of using novel solid forms of tacedinaline
    Patent number: 8729130
    Abstract: Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Forms A, B, and D, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Forms A, B, and D, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed.
    Type: Grant
    Filed: September 15, 2012
    Date of Patent: May 20, 2014
    Assignee: The Broad Institute, Inc.
    Inventors: Edward Holson, Florence F. Wagner, G. Patrick Stahly
  • Solid forms of tacedinaline
    Patent number: 8691875
    Abstract: Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Forms A, B, and D, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Forms A, B, and D, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed.
    Type: Grant
    Filed: September 15, 2012
    Date of Patent: April 8, 2014
    Assignee: Broad Institute, Inc.
    Inventors: Edward Holson, Florence F. Wagner, G. Patrick Stahly
  • NOVEL SOLID FORMS OF TACEDINALINE
    Publication number: 20130150450
    Abstract: Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Forms A, B, and D, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Forms A, B, and D, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed.
    Type: Application
    Filed: September 15, 2012
    Publication date: June 13, 2013
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: Edward Holson, Florence F. Wagner, G. Patrick Stahly
  • NOVEL SOLID FORMS OF TACEDINALINE
    Publication number: 20130102677
    Abstract: Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Forms A, B, and D, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Forms A, B, and D, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed.
    Type: Application
    Filed: September 15, 2012
    Publication date: April 25, 2013
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: Edward Holson, Florence F. Wagner, G. Patrick Stahly
  • Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives
    Patent number: 8389732
    Abstract: The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: March 5, 2013
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence F. Wagner, Pauline Ondachi
  • Chemokine receptor modulators
    Patent number: 8338448
    Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and/or esters thereof. These compounds, and pharmaceutical composition comprising such compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: December 25, 2012
    Assignee: Altiris Therapeutics, Inc.
    Inventors: Michael P. Clark, Florence F. Wagner, Brandon C. Doroh, Tricia L. Johnson, Yesim Altas Tahirovic, Lawrence Wilson, John M. Wiseman, Jason W. Skudlarek, Mark A. Lockwood, Michael G. Natchus
  • SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES
    Publication number: 20100331323
    Abstract: The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.
    Type: Application
    Filed: September 10, 2010
    Publication date: December 30, 2010
    Inventors: Daniel L. Comins, Florence F. Wagner, Pauline Ondachi
  • Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives
    Patent number: 7820826
    Abstract: The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: October 26, 2010
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence F. Wagner, Pauline Ondachi
  • Chemokine Receptor Modulators
    Publication number: 20100029634
    Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and/or esters thereof.
    Type: Application
    Filed: March 30, 2009
    Publication date: February 4, 2010
    Inventors: Michael P. Clark, Florence F. Wagner, Brandon C. Doroh, Tricia L. Johnson, Yesim Altas Tahirovic, Lawrence Wilson, John M. Wiseman, Jason W. Skudlarek, Mark A. Lockwood, Michael G. Natchus