Patents by Inventor Florence M. Hoffman

Florence M. Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER
    Publication number: 20180360843
    Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
    Type: Application
    Filed: August 22, 2018
    Publication date: December 20, 2018
    Inventors: Jean C. Shih, Florence M. Hoffman, Thomas C. Chen
  • MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer
    Patent number: 10125099
    Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: November 13, 2018
    Assignee: University of Southern California
    Inventors: Jean C. Shih, Florence M. Hoffman, Thomas C. Chen
  • MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER
    Publication number: 20170029371
    Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Jean C. Shih, Florence M. Hoffman, Thomas C. Chen